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Biomedical subjects

L L Humphries

Publications and source records attributed to L L Humphries.

29 records · Page 2Linked to original sources
PubMed1986

Neuropsychological test performance of bulimic patients.

Thirty subjects with DSM-III diagnoses of bulimia were compared to 30 matched controls on the Luria-Nebraska Neuropsychological Battery. The bulimics showed poorer performance on tasks associated with functioning of the right frontal cortical area, primarily tasks involving speed of drawing geometric figures. The similarities of the findings to previous findings with anorexic samples and patients with affective disorders are discussed.

Adolescent↗
PubMed1986

Mitral valve prolapse in patients with anorexia nervosa and bulimia.

We studied 43 consecutive individuals with eating disorders (anorexia nervosa and/or bulimia) for the presence of mitral valve prolapse and/or cardiac arrhythmias by physical examination, M-mode and two-dimensional echocardiography, and 24-hour continuous ambulatory electrocardiographic monitoring. Ten of the 43 had findings of mitral valve prolapse on resting cardiac auscultation. Echocardiographic evaluation confirmed the diagnosis of mitral valve prolapse in these ten as well as in six other individuals, giving an overall incidence of 37% (16/43). Similar echocardiographic findings were present in only 4% (1/23) of control individuals. Cardiac arrhythmias other than benign isolated premature extrasystoles were noted in five patients with eating disorder; all five also had echocardiographic findings of mitral valve prolapse. The incidence of mitral valve prolapse appears to be increased in patients with eating disorders. In addition, the arrhythmogenic effects of mitral valve prolapse may present an additional risk factor in these patients.

Adolescent↗
PubMed1985

Daily patterns of serotonin uptake in platelets from psychiatric patients and control volunteers.

Serotonin (5-HT) uptake into platelets from psychiatric patients and controls was measured in the morning and afternoon. Uptake varied with time of day in both groups studied, resulting in four recognizable patterns. Two patterns occurred in the majority of controls. In contrast, uptake patterns in the psychiatric patients were more variable, with each of the four patterns clearly represented. However, except for the fact that uptake was significantly decreased throughout the day in depressed patients, the patterns were not otherwise linked statistically to clinical condition. In any event, the greater variability of daily 5-HT uptake patterns in patients suggests that psychiatric disorders linked presumably to central nervous system (CNS) dysfunction are in some way reflected by labile platelet 5-HT pharmacokinetics.

Adolescent↗
PubMed1985

Sequential quantitative EEG analysis in acute lymphocytic leukemia of children.

Potential brain toxicity is a major concern in the treatment of acute lymphocytic leukemia with cranial irradiation or intrathecal methotrexate. We used quantitative EEG analysis based on the Fourier transform to study 13 children at the time of diagnosis, after induction, and following consolidation which included extended intrathecal chemotherapy. None had detectable CNS infiltration by leukemia. Nonetheless, initial EEG frequencies were markedly depressed compared to expected values for age (p less than .001), and improved dramatically after induction (p less than .001). Following consolidation, EEG frequencies remained significantly lower than predicted from a control population (p less than .05). Quantitative EEG is a sensitive procedure that appears useful in assessing subtle neurologic effects of acute leukemia and its treatment.

Adolescent↗
PubMed1983

Bulimia: the binge eating syndrome.

Bulimia occurs in roughly half of obese and anorexic patients. A recent study found 19% of female and 5% of male college students to be bulimic. Binge eating usually comes to the physician's attention from problems associated with purging measures--diuretics, laxatives, or self-induced postprandial vomiting--used by one out of ten bulimic patients. Continuous vomiting causes parotid enlargement, sore throat, spontaneous regurgitation, and severe electrolyte imbalance. We report a case illustrating the bulimic's distorted body image, review alternative treatment methods, and suggest needed areas of research, particularly those elucidating the relationship between bulimia and affective disorders.

Adolescent↗
PubMed1982

Anorexia nervosa.

Anorexia nervosa typically occurs in a "model child" of a family that values achievement, appearance and nonconflictual interactions. Three diagnostic criteria are weight loss of at least 25 percent of ideal body weight, physiologic changes (including amenorrhea) and a distorted body image in which the patient, even when cachectic, insists she is fat. Therapy must involve the entire family, focusing not on pounds gained but on learning to handle conflict.

Adolescent↗