PubMed Health⌕ Search

Biomedical subjects

L Lachhein

Publications and source records attributed to L Lachhein.

At least 19 recordsLinked to original sources
PubMed1988

[Treatment of plasmacytoma with hyperviscosity syndrome].

It is reported on the treatment of three patients with a hyperviscosity syndrome in IgG-plasmocytoma. Before every polychemotherapy cycle a plasma exchange was carried out, when the total protein in the serum and the immunoglobulins were essentially increased and clinical symptoms of the hyperviscosity syndrome were existing. The results and the possible effects on the efficacy of the therapy with cytostatic agents are discussed. In the light of our experiences we can recommend the membrane plasma filtration treatment as symptomatic therapeutic measure in the hyperviscosity syndrome.

Aged↗
PubMed1987

[Blood purification procedures in acute exogenous poisonings].

The contribution explains the value of the techniques of blood purification on the basis of national numbers and own experiences. By reason of the great number of chemical substances which may give rise to intoxications within such a close compass it is of course impossible to mention details. Even so eminent books of reference such as the book by Seyffart need not only the permanent actualization, but by virtue of new scientific or experimental knowledge occasionally lead to changed conceptions. This, for instance, also concerns the somewhat more reserved assessment of the digitalis glycoside poisoning. On principle should be recorded that always then, when during intoxications vital functions are potentially or actively disturbed, or, however, the danger of lasting damage is occurring, because of the small complication rate of the haemodialysis or haemoperfusion in all unclear intoxications in case of doubt always such a blood purification technique should be performed in order to grant better changes of treatment to these patients and still further to reduce the mortality rate of acute intoxications.

Blood↗
PubMed1986

[Accelerating factors in the progression of chronic renal failure].

A simple and reliable possibility to recognize at once sudden deteriorations of the renal function is the demonstration of IgKr accompanying the disease by means of semilogarithmic paper. Up to now probably no special importance has been attached to an intensive treatment of hypertension. The kinetics of the initial loss of function further remains unclear. The importance and possible influence on the accelerating factors must be defined exactly in a longer period of observation and with a greater number of patients. If we succeed in avoiding the acceleration and even in retarding the progression this would be connected with an essential delay of the time of the dependence upon dialysis for a number of patients.

Creatinine↗
PubMed1986

[Retrospective follow-up control of progressive renal failure with logarithmic transformation of the serum creatinine concentration].

Of 108 patients with chronic terminal renal insufficiency in 81 patients controls of the course were possible. In 50 patients an lg-linear course of the increase of creatinine against the time was the result. The running through time from 200 to 1,000 mumol/l creatinine was measured. In 31 patients the at first flatter, also linearly recognizable increase of creatinine suddenly changed into a second steeper, also lg-linear part of the straight line. The exact knowledge of the accelerating factors might postpone the time of the dialysis dependence in one part of the patients.

Creatinine↗
PubMed1985

[Folic acid deficiency anemia caused by therapy in chronic renal insufficiency].

The turbidimetric determination of folic acid concentration in serum and erythrocytes was made by means of a spectrophotometer multiscan in 35 conservatively treated patients with chronic renal failure with a minimum creatine retention of 309 mumol/l and in 63 hemodialysed patients with terminal renal insufficiency. The result showed a statistically significant diminution of serum folic acid concentration in those patients treated in a conservative manner and a significant diminution of plasmatic and erythrocytic folate++ activity in patients under hemodialysis. There was a correlation between the folic acid concentration and the hemoglobin level in both groups of patients, whereas there was no correlation to the number of leukocytes and thrombocytes. A protein deficiency diet or loss of dialysis through the capillary membrane could be found to be the cause for the loss of folic acid. The possibility of folate++ substitutive therapy and its performance was discussed and recommended for selected indications.

Adult↗
PubMed1984

[Catamnestic study of long-term prognosis in patients with acute kidney failure].

Of 250 patients who were haemodialyzed on account of an acute renal insufficiency during a period of 16 years 114 patients survived. A control of the course was performed in 105 patients. Altogether 34 patients dies after their discharge from hospital. Older age and acute renal insufficiency due to urological basic diseases or abscessing pyelonephrititides have clearly worse cumulative survival rates. The risk factors of chronic pyelonephritis and hypertension, respectively, are found in one third of the patients. The long-term prognosis after acute renal insufficiency can be improved by regular dispensary care.

Acute Kidney Injury↗
PubMed1981

[The significance of "slight proteinuria"].

It is reported on renal biopsies in 67 patients with "slight proteinuria", 39 of whom were at an age of younger than 20 years. In 53 patients the cause of the "slight proteinuria" is a mesangio-proliferative glomerulonephritis, where in 2 cases severe changes with sclerosis were proved. Thus by way of addition the necessity of a renal biopsy is emphasized for the clarification of the cause also of a "slight proteinuria".

Adolescent↗
PubMed1980

[Dangers of drug and surgical treatment in chronic renal failure (conclusion)].

Patients at the stage of advanced renal insufficiency with and without haemodialytic treatment are in general exclusively treated by the nephrologist. Nevertheless, some of these patients consult other physicians when complications or a second disease appear. According to our experiences to this belong above all emergency cases, such as feverish infections, disturbances of the gastrointestinal tract, fractures, combustions but also gynaecological diseases, inoculations or diseases of the teeth. In these cases the patient at the stage of the compensated retention not infrequently conceals the size of his renal disease, or the physician in charge underestimates the sequels of numerous medicamentous or operative therapies. On account of the dangers therefore the cooperation with the nephrologist is necessary.

Diagnosis, Differential↗
PubMed1980

[Drug therapy in renal failure].

The excretion of medicaments and their metabolic products essentially takes place through kidneys and liver. In case of a functional disturbance of the kidneys in medicaments with considerable renal elimination a damming up of active substances develops. Therefore, with so-called normal doses considerable toxic injuries may appear. Possibly medicaments should be used, the renal elimination of which is only slight. Drugs with prevailing excretion via kidneys must be reduced according to the degree of the renal insufficiency. In case of a haemodialytic treatment on the other hand medicaments are removed from the body without control. On principle in renal insufficiency each unnecessary medicamentous treatment should be avoided and only controllable or in their elimination kinetics known medicaments should be used.

Biotransformation↗
PubMed1979

[Eye fundus pathology in chronic terminal kidney failure].

On 75 patients with chronic renal insufficiency the relations between renal hypertension due to volume expansion and findings of the fundus of the eye were investigated. In compensated renal insufficiency in 20 of 23 patients a hypertension appeared, hypertensively conditioned changes of the fundus were observed only in about one third of the cases. When the functional disturbances progressed into the stage of the chronic terminal renale insufficiency on the other hand in 27 of 38 patients retina findings conditioned by hypertension were stated. Among 38 haemodialysis patients by regulation of the fluid balance 11 times a normal fundus and 15 times an improvement of the findings of the fundus of the eye could be revealed. In 13 patients the findings of the fundus generally improved after successful renal transplantation. Also our examinations call the usual stage subdivisions after Thiel and Keith and co-workers, respectively, in question.

Adolescent↗
PubMed1978

[Treatment of acute kidney failure].

By the rapid development of the chronic haemodialysis and the transplantation of kidneys the treatment of the acute renal failure is not so often dealt with in literature, though the haemodialysis since its clinical use in 1944 for 15 years exclusively has been used for the treatment of acute renal failure. Alarming reports on the increase of the mortality up to 80% were the cause to deal with treatment and developmental tendencies in form of a survey. The conclusions were that during the last 6 years in the GDR annually about 300 cases of acute renal failure are constantly treated. The total mortality rate is without any essential variations on an average about 44.9%. In comparison to international statistics these figures are remarkably good. According to the basic etiological cause of the acute renal failure the mortality rate varies between 60% in surgical diseases and about 30% in intoxications with uraemia. Apart from these analyses the author enters indication, causes and prognosis in form of a summary.

Acute Kidney Injury↗