PubMed Health⌕ Search

Biomedical subjects

L Lafferty

Publications and source records attributed to L Lafferty.

4 recordsLinked to original sources

Marijuana use prevention: the In-DEPTH model program.

Over the past five years marijuana use has doubled among eighth, 10th and 12th grade students, and in several demographics it has tripled. The recent debate over the legalization of medical marijuana (California's Proposition 215), positive media messages, lack of parent/child discussion, and denial by schools and communities may be contributing factors to the rise of drug use among adolescents. The In-DEPTH program, a unique drug education model that educates, prevents, and provides intervention strategies in adolescent marijuana use, has in small multisite surveys shown initial success in decreasing marijuana use and positively changing beliefs. The program is based on pharmacology, addiction medicine principles, economics and the pharmaceutical sales model, and examines drug dealing as well as drug use.

Adolescent↗

Stability of Revex, nalmefene hydrochloride injection.

The stability of Revex, nalmefene hydrochloride injection, has been studied at several temperatures for periods up to 36 months. The data were obtained using a HPLC method for the potency determination, and for the level of the sole degradation product (2,2'-bisnalmefene). These methods were found to be characterized by excellent precision, linearity, and accuracy over the analyte concentration ranges established. The stability data were found to be interpretable using first-order kinetics, and essentially comparable rate constants were calculated for both the potency loss and the formation of 2,2'-bisnalmefene. Applying the Arrhenius equation to these data, a rate constant of 0.00441 month-1 was deduced for the reactions taking place at 25 degrees C. This low value is consistent with the excellent stability exhibited by the product, and amply justifies its shelf life.

Chromatography, High Pressure Liquid↗