Biomedical subjects

L Lahdelma

Publications and source records attributed to L Lahdelma.

2 recordsLinked to original sources

PubMed1998

Should thyroid augmentation precede lithium augmentation--a pilot study.

BACKGROUND: It has not been investigated whether thyroid augmentation should precede lithium augmentation or vice versa. METHODS: In 22 outpatients with major depression not responsive to 4 weeks of antidepressant treatment, the effect of subsequent 4 weeks of thyroxine administration followed by 4 weeks of lithium augmentation was compared with the effect of the same treatments in reverse order. RESULTS: The percentage reduction in MADRS score was significantly greater in patients who started on thyroxine. CONCLUSIONS: Thyroxine augmentation should precede lithium augmentation. LIMITATIONS: We used relatively small doses of lithium. CLINICAL RELEVANCE: Thyroxine is effective in augmenting antidepressant responses.

Adolescent↗

PubMed1998

Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication.

We report an association between HLA-A1 allele and a subgroup of schizophrenic patients refractory to conventional neuroleptic treatment but responsive to clozapine. The frequency of HLA-A1 was 58% among the schizophrenic patients not responding to conventional treatment but responsive to clozapine but only 10.5% among the patients responding to conventional neuroleptics. The HLA-A1 occurs in 20% of the random Finnish population. Our results indicate that HLA-A1 defines a subgroup of schizophrenic patients with a selective response to neuroleptics.

Adult↗