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Biomedical subjects

L Laslett

Publications and source records attributed to L Laslett.

5 recordsLinked to original sources
PubMed1988

Aerobic exercise training reduces resting and exertional blood pressure in cardiac patients.

We evaluated the effects of exercise training (ET) on resting and exertional blood pressure in patients with cardiac disease. ET consisted of 20 to 30 minutes of aerobic activity three times weekly for 12 months. The study group comprised 17 males and three females (mean age 58 years, range 40 to 71 years). Blood pressure was evaluated at rest and during exercise after 6 and 12 months ET. A training effect was documented by an increase in functional capacity from 7.5 METs (1 MET = 3.5 mL oxygen consumption/kg/min) pre-ET to 8.8 and 9.2 METs after 6 and 12 months, respectively. The following significant (P less than 0.05) effects occurred on blood pressure in association with ET: resting systolic pressure pre-ET decreased from 131 to 124 mm Hg at 12 months ET; submaximal (50% pre-ET maximum capacity) systolic and diastolic pressures decreased from 150/84 to 142/80 mm Hg (6 months ET) and 144/80 mm Hg (12 months ET); diastolic pressure at maximal exertion fell from 83 to 77 mm Hg (6 months ET) and 78 mm Hg (12 months ET). Systolic blood pressure at maximal exertion was not increased despite significant increases in peak workload achieved at 6 and 12 months ET. Therefore, ET not only enhances functional capacity in cardiac patients but may be associated with a beneficial cardiac effect through attenuation of both rest and exertional blood pressure.

Adult↗
PubMed1987

Exercise training in coronary artery disease.

Physical training using dynamic, nonisometric exercise can increase physical endurance and decrease cardiac work load of submaximal exertion. This is true for people with coronary artery disease and for normal individuals, and it may also be true for those with selected other cardiac diseases. Effective training should involve exercise at between 70 and 85 per cent of predicted maximal heart rate for 15 to 20 minutes or more at least three times a week. An exercise prescription should be written on the basis of individual patient needs and limitations and utilizing an exercise electrocardiogram test. Medically supervised exercise programs allow physical training for patients with heart disease to be conducted safely and efficiently. The effect of training in coronary disease patients is primarily attributable to increased efficiency of peripheral musculature and circulation; how much true cardiac adaptation results is variable. Training improves psychologic outlook, probably reduces selected risk factors for coronary disease, and may improve longevity.

Adrenergic beta-Antagonists↗
PubMed1987

Exercise and sudden death.

Sudden death during exercise is rare, but limited data suggest that vigorous physical activity is associated with an increased risk for this event, particularly in individuals with overt cardiac disease or a high coronary risk profile. The mechanism of exercise-associated sudden death is usually a lethal arrhythmia; however, this may vary depending on the underlying cardiovascular disease. In the great majority of cases, cardiovascular disease is present in persons who die during exercise. In young individuals (less than 35 years old) hypertrophic cardiomyopathy and congenital coronary anomalies are the most common conditions, whereas older victims usually have coronary artery disease. Cardiac disease is typically unrecognized prior to death in young persons; in the older population, most have overt coronary disease or recognizable coronary risk factors. Screening asymptomatic individuals to identify increased risk of a cardiac event during exercise presents major problems in terms of logistics, expense, and accuracy, but careful evaluation, including exercise testing, is mandatory before a program of increased activity in patients with overt cardiac disease. In other cases, the extent of any evaluation must be determined on an individual basis.

Adult↗