A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin.
[reaction: see text]. An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proceeded in good yield under high-dilution conditions.
Antibiotics, Antineoplastic↗