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Biomedical subjects

L Lemarbre

Publications and source records attributed to L Lemarbre.

15 recordsLinked to original sources
PubMed1999

Early and long-term results of percutaneous transluminal angioplasty of the lower abdominal aorta.

PURPOSE: The purpose of this study was to determine the early and long-term results of percutaneous transluminal angioplasty (PTA) of atherosclerotic lower abdominal aorta stenosis. METHODS: This study was performed as a retrospective study. From 1980 to 1997, 46 patients with chronic lower limb ischemia with moderate to severe claudication as the result of isolated infrarenal disease or aortoiliac disease underwent PTA. All patients underwent angiography before and after angioplasty and Doppler ultrasound scan examination with ankle-brachial index determination. No stents were used. RESULTS: The technical success rate was 96% (44 of 46 cases). Thirty-eight patients (83%) immediately showed clinical, hemodynamic, and angiographic improvement. The initial success rate for patients with isolated infrarenal or bifurcation disease was 92%, whereas it was 71% for aortoiliac disease. Among the eight patients with no initial improvement, four had clinical deterioration and two required emergency surgical revascularization. There were no other complications. Fifty-six percent of the patient conditions (95% confidence interval [CI], 38% to 74%) remained clinically improved at the 5-year follow-up examination. Recurrence of symptoms was caused by femoropopliteal disease in most patients. The primary patency rate assumed with maintenance of hemodynamic improvements was 70% (95% CI, 52% to 88%) and 64% (95% CI, 44% to 84%) at 4 and 5 years of follow-up, respectively. The primary patency rate at 4 years for patients with isolated infrarenal or bifurcation disease was 83% (95% CI, 64% to 100%), whereas it was 55% for aortoiliac disease (95% CI, 30% to 80%; P =.06) The variables that were statistically predictive of patency failure were poor runoff (P =. 01) and presence of aortoiliac atherosclerotic disease (P =.04). CONCLUSION: Our results suggest that PTA is an excellent treatment for chronic arterial insufficiency of the lower extremities as the result of isolated atherosclerotic lower abdominal aortic occlusive lesions because of good long-term patency. Aortic PTA for those patients with iliac involvement or with poor runoff gives acceptable results but carries lower patency and clinical success rates.

Adult↗
PubMed1993

Transluminal angioplasty of the subclavian artery in patients with internal mammary grafts.

From January 1987 to January 1992, 11 patients underwent percutaneous transluminal angioplasty (PTA) for the treatment of subclavian artery stenosis before or after coronary artery bypass grafting (CABG) using the internal mammary artery (IMA). There were 8 men and 3 women, with a mean age of 57 +/- 7 years. Four patients had PTA 1 to 4 months before undergoing CABG with IMA grafts, because of either asymptomatic supraclavicular murmurs or neurologic symptoms. Seven patients underwent PTA 2 to 37 months after CABG with IMA grafts, because of recurrent angina. Subclavian artery stenosis was on the left side in 9 patients, the right side in 1 patient, and bilateral in 1 patient. Ten PTA procedures were successful in 9 patients. All patients with post-CABG angina had reversal of the ischemia. There were three complications: one femoral artery thrombosis, one brachial plexus hematoma after an axillary approach, and one acute pulmonary edema after the procedure. Follow-up after PTA ranged from 1 to 60 months (mean, 38 +/- 17 months). Nine patients had no angina at follow-up and 2 had stable angina (class II) upon exertion. Upper-limb Doppler studies showed no evidence of restenosis in any of these patients at a mean follow-up of 38 months. Subclavian artery PTA is a useful alternative to IMA bypass grafting in patients with subclavian artery stenosis discovered preoperatively, and it is the treatment of choice for those presenting with post-CABG angina due to subclavian artery stenosis proximal to an IMA graft.

Adult↗
PubMed1993

[Results of percutaneous dilatation of subclavian artery stenosis in patients with internal mammary grafts].

From January 1987 to January 1992, 11 patients underwent percutaneous transluminal angioplasty (PTA) for subclavian artery (SCA) stenosis before or after coronary artery bypass grafting (CABG) with the internal mammary artery (IMA). There were 8 men and 3 women with a mean age of 57 +/- 7 years. Four patients had PTA 1 to 4 months before undergoing CABG with IMA grafts, because of asymptomatic subclavian murmurs or of neurologic symptoms. Seven patients underwent PTA 2 to 37 months after CABG with IMA grafts, because of recurrent angina. Subclavian artery stenosis was present on the left side in 9 patients, the right side in one patient, and was bilateral in one patient. Ten PTA procedures were successful in 9 patients. All patients with post-CABG angina had reversal of the ischemia. Three complications occurred: 1 femoral artery thrombosis, 1 branchial plexus hematoma after an axillary approach, and 1 acute pulmonary edema after the procedure. Follow-up ranged from 1 to 60 months after PTA (mean 38 +/- 17 months). Nine patients had no angina at follow-up and 2 presented with stable angina (class II) upon exertion. Upper-limb Doppler studies showed no evidence of restenosis in all of these patients, at a mean follow-up of 38 months. Subclavian artery percutaneous transluminal angioplasty is a useful alternative for candidates to IMA bypass grafting with SCA stenosis discovered pre-operatively, and it is the treatment of choice for those presenting with post-CABG angina due to SCA stenosis proximal to an IMA graft.

Angioplasty, Balloon↗
PubMed1991

Coronary artery stenting after angioplasty with self-expanding parallel wire metallic stents.

Parallel wire stents were implanted over exchange guide wires at percutaneous transluminal coronary angioplasty sites in 27 canine coronary arteries that were predilated with slightly oversized balloons. Stents were stainless steel, self-expandable, 3.5 to 4.5 mm in diameter, 9 to 12 mm in length, and were made of 10 wires that were longitudinally laser-welded in a zig-zag design. The compressible stent was delivered by the withdrawal of a Teflon outer catheter (4.2 to 4.9F) and the push of a polyethylene inner catheter. Aspirin, 80 mg per day, was given from the day before the study began, and heparin (150 U/kg) was administered during implantation. Quantitative angiography and pathologic examinations were performed at day 0 and at weeks 2, 4, 12, 26 and 52. The coronary angiographic diameter at the stent site immediately after stenting marginally increased from diameter before stenting: 3.22 +/- 0.40 mm versus 3.14 +/- 0.37 mm (p = 0.03), and during a mean of 14 weeks of follow-up, remained unaltered from immediate post-stenting: 3.29 +/- 0.43 mm versus 3.22 +/- 0.40 mm (p = NS) with no stent displacement. Comparisons of patency and thrombosis between heparin-coated and uncoated stents, between left anterior descending and circumflex arteries, and among the three different diameters of stents showed uniformly good results. At microscopy, the wires were oriented perfectly and embedded in the arterial wall, and by 2 weeks they were covered by mucopolysaccharide ground substance, smooth muscle cells, and an almost complete monolayer of neoendothelial cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Angioplasty, Balloon, Coronary↗
PubMed1990

A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis.

To determine whether calcium channel blockers influence the progression of coronary atherosclerosis, 383 patients age 65 years or less with 5-75% stenoses in at least four coronary artery segments were selected at random within 1 month of coronary arteriography to participate in double-blind therapy with a placebo or nicardipine 30 mg three times daily. Coronary events (5 deaths, 22 myocardial infarctions, and 28 unstable anginas) occurred in 28 of 192 nicardipine patients and 23 of 191 placebo patients (p = NS). At 24 months coronary arteriography was repeated in 335 patients. Progression, defined as a 10% or more worsening in diameter stenosis, measured quantitatively, was found in 147 of 1,153 lesions (12.7%) in 168 nicardipine patients and in 170 of 1,170 lesions (14.5%) in 167 placebo patients (p = NS). Ninety-two nicardipine patients (55%) and 95 placebo patients (57%) had progression at one or more sites (p = NS). Regression, that is, an improvement by 10% or more in diameter stenosis, was seen in 140 of 2,323 lesions (6.0%) overall, with no significant intergroup difference. Among the 217 patients with 411 stenoses of 20% or less in the first study, such minimal lesions progressed in only 15 of 99 nicardipine patients compared with 32 of 118 placebo patients (15% versus 27%, p = 0.046). In this subgroup, 16 of 178 minimal lesions in nicardipine patients and 38 of 233 minimal lesions in placebo patients progressed (p = 0.038). By stepwise logistic-regression analysis, baseline systolic blood pressure (p = 0.04) and the change in systolic blood pressure between baseline and 6 months (p = 0.002) correlated with progression of minimal lesions. This suggested blood pressure reduction may account for the beneficial action of nicardipine. These results suggested nicardipine has no effect on advanced coronary atherosclerosis but may retard the progression of minimal lesions.

Adult↗
PubMed1988

Assessment of left ventricular function using digital angiography.

We have demonstrated that selective digital left ventricular angiography using small amounts of contrast material minimized both symptoms and hemodynamic alterations and provided good images for assessment of regional ventricular function. However, comparisons of ejection fraction (EF), end-systolic volume (ESV), and end-diastolic volume (EDV) from digital angiography, at 10 frames per second, with measurements derived from conventional angiography, showed only a fair correlation between the two methods. Using a new generation of digital equipment and an acquisition time of 30 frames per second, we studied the correlation between digital and conventional angiography in 29 patients with coronary artery disease for a wide spectrum of left ventricular functions. Ventricular volumes and EF were calculated by computer using the area-length method. The correlation coefficient (r) between both the methods was 0.93 for EF, 0.95 for ESV and 0.89 for EDV. Thus digital left ventricular angiography provides an accurate evaluation of left ventricular function and can with advantage replace conventional angiography for this purpose.

Adult↗
PubMed1987

Design features of a controlled clinical trial to assess the effect of a calcium entry blocker upon the progression of coronary artery disease.

This report presents the design and methodological features of a double-blind, randomized, placebo-controlled, trial in 383 patients with coronary artery disease. The study's principal objective is to determine whether chronic treatment with a calcium entry blocker can retard the progression of coronary artery disease. The study population consists of patients with coronary artery disease and a baseline coronary arteriogram that qualifies them as being at high risk for disease progression. After satisfying all entry criteria, patients were randomized to receive either the calcium entry blocker nicardipine or placebo. All indicated concomitant medications except calcium entry blockers are permitted. Patients are being followed clinically for 24 months before undergoing a second coronary arteriogram. The effect of the treatments on a variety of clinical and angiographic parameters will be determined.

Adult↗
PubMed1987

Outpatient peripheral angioplasty: survey of complications and patients' perceptions.

We report our experience with a total of 79 peripheral angioplasties performed in 64 patients on an outpatient basis between July 1983 and April 1985. Review of the medical files and a telephone inquiry in 58 subjects (72 angioplasties) revealed no major complications, a low rate of minor complications (1.5%), and a high degree of patient satisfaction (99%).

Adult↗
PubMed1984

Usefulness of digital subtraction left ventriculography in patients with ischemic heart disease: comparison with cineangiography.

Digital subtraction and computer enhancement of left ventriculography allow the injection of small amounts of contrast medium into the left ventricle. Image quality measurements of cardiac volumes, and ejection fraction and evaluation of regional wall motion were compared following digital subtraction and cine ventriculography in 30 patients undergoing coronary arteriography for suspected or proven ischemic heart disease. At concentrations of 13% to 19% (iodine contents: 2.0 to 5.0 g) meglumine sodium diatrizoate used for digital subtraction ventriculography, no alterations of ventricular pressures were noted; premature ventricular contraction and cineventriculography in 30 patients undergoing coronary arteriography for suspected wall motion by two independent observers showed complete agreement between digital and cineventriculography in 141 of 150 segments (94%), including 114 normal segments; digital ventriculography led to underestimation of four segments and to overestimation of five. Left ventricular ejection fraction and volumes calculated using both techniques correlated relatively well (ejection fraction: r = 0.86; end systolic volume: r = 0.88; end diastolic volume: r = 0.665). Thus, intraventricular injection of low concentrations of contrast medium provides good digital angiographic images and may eventually replace cine ventriculography for invasive assessment of left ventricular performance. However, ECG gating and shorter exposure times will be required for accurate measurement of ventricular volumes and ejection fractions.

Adult↗
PubMed1984

Comparison of digital and radionuclide left ventriculography in patients at risk from conventional left ventriculography.

In this study, two alternative methods of assessing left ventricular (LV) sequential wall motion and ejection fraction (EF) were used in 28 consecutive patients in whom an unstable clinical condition (unstable angina pectoris or severe LV dysfunction) precluded the use of high volume contrast cineventriculography. A new approach, direct small volume contrast digital ventriculography, was compared to radionuclide blood pool ventriculography considered as a "standard" and reliable technique. The qualitative analysis of regional LV contraction by three independent observers showed a complete agreement in 64% of segments studied in the left anterior oblique (LAO) projection and in 69% in the right anterior oblique (RAO) projection; a one-degree disagreement was observed in 13% and 19% respectively, and a discrepancy of two degrees or more in 23% and 12% respectively. Left ventricular ejection fraction calculated from both techniques correlated relatively well (r = 0.82). The radionuclide examination still remains the fastest, easiest and most objective way to appraise global LV function in high risk patients. However, optimal analysis of segmental wall motion requires invasive digital contrast left ventriculography. In future, a more general use of non-ionic contrast media including their intravenous injection and the advent of portable digital devices should permit their widespread use as a safe, rapid and reliable procedure even in the intensive care unit.

Adult↗
PubMed1979

Ewing's sarcoma in adults.

Twenty-two adult patients, aged 18 and over, with Ewing's sarcoma of bone, were evaluated clinically and radiographically. They had clinical findings similar to younger patients with Ewing's sarcoma, except that they presented with fewer systemic symptoms. The radiographic characteristics included a preponderance of flat bone involvement (54%) over long bone involvement (36%). A soft-tissue mass was detected in only 55% of the cases. CT scans, when used, proved to be helpful in delineating a soft-tissue mass associated with the bony lesion, and in follow-up after therapy.

Adolescent↗
PubMedDate not supplied

[Percutaneous transluminal angioplasty of peripheral arteries: past, present and future].

Balloon percutaneous transluminal angioplasty (PTA) has been described in 1974 and has since been considerably refined with the improvement of balloon catheters, guide wires and radiology equipment. Laser and other mechanical recanalization devices have not hold to their initial promises. Clinical and angiographic indications for PTA have been better defined over the years, resulting in excellent clinical successes with low morbidity and very low mortality. PTA has become an almost painless procedure and may be done on an outpatient basis. It is considered as the treatment of first choice in suitable patients.

Adult↗
PubMedDate not supplied

[Vascular radiology without hospitalization. Apropos of 306 angiographies and/or peripheral percutaneous transluminal angioplasties done on an ambulatory basis].

A study on the safety of outpatient angiography and interventional radiology was undertaken. The authors reviewed the medical files of 286 patients and conducted a late telephone inquiry in 249 patients (87%) who underwent these procedures on an outpatient basis : arteriographies (221) or percutaneous transluminal angioplasties (76) and a few intravenous studies (9). The results revealed a high degree of satisfaction from the patients (98%), no major complications and a very low incidence of minor complications (3%).

Adolescent↗