PubMed Health⌕ Search

Biomedical subjects

L Lenhard

Publications and source records attributed to L Lenhard.

5 recordsLinked to original sources
PubMed1983

Acupuncture in the prophylactic treatment of migraine headaches: pilot study.

This study was planned as a pilot study to determine to what extent acupuncture might help in severe cases of migraine and, if possible, to see whether the mechanism was endorphin mediated. The study was carried out on 16 subjects who had severe and regular migraine for more than five years (mean duration 24 years). The study lasted eight months and was divided into four blocks of two months each: pre-treatment, treatment block I, treatment block II, and post-treatment. It was double-blind and cross-over in design. Acupuncture was found to cause a significant change in the number of headaches and their duration, with 40% of the subjects showing a 50%-100% reduction. Although pain sensation was not altered, attacks were less severe and less often accompanied by nausea and vomiting. At no stage was there any difference between subjects receiving saline or naloxone so that the possibility of a non-endorphin mechanism must be considered.

Acupuncture Therapy↗
PubMed1982

Coping with a stressful sigmoidoscopy: evaluation of cognitive and relaxation preparations.

Sigmoidoscopy involves the insertion of a small scope into the anal cavity to inspect for abnormalities in the colon. Although the procedure is not believed to be painful, it is often noxious for patients because it produces embarassment and discomfort. We examined the effectiveness of two brief interventions designed to enhance coping: self-instructional training and relaxation. In the self-instructional conditions patients were given brief training to focus their attention on either their own (internal) or the doctor's (external) ability to regulate the situation. A third (control) group received attention but did not experience self-instructional training. Half of each of these three groups also received relaxation training, while the other half did not. Planned comparisons demonstrated that subjects in the self-instructional strategies rated themselves as less anxious, had fewer body movements during the exam, and emitted fewer verbalization than those in an attention control group. Patients in the external condition estimated that the exam took less time but tended to have elevated heart rates during the procedure. Those experiencing relaxation training tended to overestimate the duration of the exam, but made fewer requests to stop the exam and rated themselves as less anxious than patients who did not receive relaxation training.

Adaptation, Psychological↗
PubMed1982

The interaction of lithium and time-of-day on calcium, magnesium, parathyroid hormone, and calcitonin in rats.

Effects of lithium on the concentrations and temporal patterns of serum and cerebellar calcium and magnesium, parathyroid hormone, and calcitonin were studied in 186 rats sacrificed around 24 hours of clock time. Serum calcium, serum and cerebellar magnesium, and parathyroid hormone were increased and calcitonin decreased in lithium-fed animals. Lithium-fed rats also showed different temporal patterns in serum calcium, parathyroid hormone, cerebellar magnesium, and calcitonin. Data support the hypothesis that lithium competes for calcium receptor sites, causing a compensatory increase in parathyroid hormone and decrease in calcitonin until a new, higher set-point for calcium is established. Lithium strongly affected biological rhythms, an effect which may account in part for the diverse literature on lithium's influence on calcium and magnesium regulation.

Animals↗
PubMed1982

Adenohypophyseal hormones in the CSF.

The presence of adenohypophyseal hormones in human cerebrospinal fluid (CSF) had been firmly established by radioimmunoassay procedures. The hormones can originate from the adenohypophysis itself and from brain, as well as from peripheral sites of production. These peptide hormones enter the CSF through the choroid plexus or by direct secretion. The hormones entering by direct secretion into the CSF have a higher CSF-blood ratio than the hormones entering through the choroid plexus. Elevated CSF levels of adenohypophyseal hormones are most likely to occur in the presence of hormone-producing pituitary tumors with suprasellar extension. Although the CSF concentrations of adenohypophyseal hormones may merely reflect their blood concentrations, it is more likely that these hormones also have paracrine as well as endocrine effects.

Adrenocorticotropic Hormone↗