Biomedical subjects
L Leonhardt
Publications and source records attributed to L Leonhardt.
[Treatment results using cefixime for bacterial respiratory tract infections].
In a prospective open clinical trial 20 patients with the diagnosis bacterial respiratory tract infection and underlying chronic obstructive lung disease were treated for 13 to 17 days with 200 mg cefixime b. i. d. 14 of 16 evaluable patients were treated successfully. In one patient the clinical symptoms remained unchanged and in another patient cefixime treatment failed. Ten of the 16 evaluable patients showed a positive baseline culture. In nine of these patients the initially isolated pathogens could be eliminated. In one patient, in whom cefixime therapy failed, change of pathogens was noticed after the end of treatment. Four of the 20 patients treated with cefixime reported side effects (gastritis, three; fungal dermatitis, one). In the patient with fungal dermatitis cefixime therapy was stopped.
[Idiopathic lung fibrosis].
In a 39-year-old patient with chronic progressive idiopathic pulmonary fibrosis, the genetic aspects, course and therapeutic possibilities of the disease are discussed. In February, 1987, the English-born patient, Anthony V., attended for initial examination on account of progressive dyspnoea, on which occasion radiology and pulmonary function analysis revealed advanced pulmonary fibrosis. The patient's family history revealed a familial genesis, since both his father (?) and his sister had died of this disease. A comparative of the patient's chest films with original chest films of his sister revealed almost identical findings. Within the previous twelve months, follow-up examinations done on A.V. revealed an increase in the restrictive component (reduction of vital capacity from 2,400 ml to 1,500 ml), development of partial respiratory failure at rest, and global respiratory failure in response to mild ergometric exercise despite intermittent high-dose steroid administrations superimposed on long-term, low-dose steroid therapy. The unfavourable evolution observed over the past 12 months is underscored by an increase in mean pulmonary arterial pressure from 18 mmHg initially to a present 34 mmHg at rest, and 46 mmHg under submaximal ergometric loading. The only option still left to the patient is the possibility of a lung transplantation, which - probably initially unilateral - is scheduled to be carried out in the near future at the Chest Surgery Department of the Medical University at Hannover.
[Primary hypoventilation syndrome in pseudo-Klinefelter syndrome].
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[Roentgenological analysis of the mobility of the diaphragm in functional pulmonary disorders (author's transl)].
Analysis of pulmonary function and densitometric examinations were carried out side by side in 41 patients with various types of pulmonary disorders. The results of both examination methods show good correlation and enable the physician to make a definite statement on the type of bronchopulmonary disease in the examined patient. The definite information which can be gained via this specific roentgenologic method justifies its use alongside the methods of pulmonary functional analysis.
[Therapy of gastric and duodenal ulcer with Metoclopramide].
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[The concept "psychobiology". Psychobiology as a scientific system].
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[Phenylketonuria. A nursing care report].
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[Modification of the phagocytic activity of the hepatic RES by PVNO (polyvinylpyridine-N-oxide)].
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[Clearance mechanism of the RES following application of high doses of Au-198 with regard to the kinetics of distribution and adaptability].
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