PubMed Health⌕ Search

Biomedical subjects

L Lindström

Publications and source records attributed to L Lindström.

88 records · Page 5Linked to original sources
PubMed1977

Naloxone-induced reversal of schizophrenic hallucinations.

In a single-blind pilot study 0.4 mg naloxone i.v. was found temporarily to reduce or abolish auditory hallucinations in four cases of chronic schizophrenia whereas saline was without effect. In one of these patients there was a similar reversal also of her visual hallucinations. Two additional cases who denied hearing voices before the injections, reported no subjective effects.

Adult↗
PubMed1977

An electromyographic index for localized muscle fatigue.

A new method for objective quantification of localized muscle fatigue is described. The method is based on power spectrum analysis of myoelectric signals obtained from the fatigued muscle. It permits real-time investigations and yields statistically based criteria for the occurrence of fatigue. The findings are interpreted in terms of muscle action potential conduction velocity changes and rate of the fatigue development.

Action Potentials↗
PubMed1975

Tissue water and pH in experimental primary cardiomyopathy induced by isoproterenol in frog.

Acute aneurysms and other morphologically defined cardiac lesions were produced in frogs by isoproterenol (IPR) as previously described. Samples from lesions verified in vivo and from macroscopically normal ventricular areas, together with samples from nontreated control animals, were analyzed for total water content, inulin space, pHe, and pHi by using DMO-14C and inulin-3H. Total cardiac tissue water content was increased in all types of lesions after IPR injection. The highest content was found in bulging, noncontractile aneurysms. Inulin space was enlarged in all heart muscle specimens from IPR-treated animals, including those without macroscopically visible lesions. Those specimens with aneurysms showed the greatest degree of enlargement. The (pHe-pHi) did not differ between injected and noninjected animals, and the noncontractile samples from aneurysms did not differ from other lesions and macroscopically intact areas. In IPR-injected animals, there was no difference in pHi between macroscopically damaged and nondamaged segments of ventricle wall. On comparing these animals to controls, however, a slight shift to the alkaline side for both pHi and pHe was observed. The (pHe-pHi) was higher in skeletal muscle than in heart muscle in both IPR-treated and nontreated animals. Tissue water increased in skeletal muscle after IPR injection, reflecting a change of intracellular water as inulin space was maintained.

Animals↗
PubMedDate not supplied

Classification of CSF samples from normal and post-partum psychotic women using chromatographic profiles with bilinear projections: a multivariate approach.

This paper demonstrates how chromatographic profiles of cerebrospinal fluid (CSF) have been subjected to multivariate data analysis to discriminate between CSF samples from women with post-partum psychosis and those from healthy women. Instead of peak-heights or areas, digitally defined chromatographic profiles were examined using principal component analysis (PCA). In accordance with the diagnosis, we have found a complex profile pattern of at least ten composite peaks that discriminates between these groups. Two of these peaks were for the discrimination particularly clearly between the two groups. We speculate that these findings can be useful in the diagnosis of post-partum psychosis, increasing diagnostic precision and having both clinical and prognostic implications.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

Acid monoamine metabolites in the CSF of healthy controls punctured without preceding strict bedrest: a retrospective study.

Data were obtained from 46 healthy volunteers, 16 males and 30 females, lumbar punctured at the L4-5 level without strict bedrest prior to puncture. 18 ml of CSF was collected at the puncture, which was performed with a 0.9 mm diameter needle. Contradictory to previous reports, body height did not influence CSF 5-hydroxyindoleacetic acid (5-HIAA) or homovanillic acid (HVA). Age influenced HVA (but not 5-HIAA) in a curvilinear manner in male volunteers and the HVA/5-HIAA ratio in females. In contrast to previously reported correlations between 5-HIAA and HVA, a weak correlation was found, but only in females. In males, body weight related to 5-HIAA and atmospheric pressure to HVA, both in a positive direction. Our findings are largely contradictory to previous reports, a fact that might, hypothetically, be due to the absence of strict bedrest before puncture. The use of a comparatively wide needle (0.9 mm in diameter) and the amount of 18 ml CSF drawn might, taken together, make at least some contribution to an explanation.

Adolescent↗
PubMedDate not supplied

Micropurification and amino acid sequence of beta-casomorphin-8 in milk from a woman with postpartum psychosis.

Milk was obtained from a woman with acute postpartum psychosis and with ongoing lactation. Defatted samples were subjected to micropurification and collected fractions were analyzed by means of their beta-casomorphin-8 immunoreactivity. Immunoreactive material with the same chromatographic properties as synthetic human beta-casomorphin-8 was determined by amino acid sequence analysis to be Tyr-Pro-Phe-Val-Glu-Pro-Ile-Pro. Its molecular mass was determined by fast atom bombardment-mass spectrometry to be 962.3 Da. These determinations, which ultimately identify the immunoreactive material as human beta-casomorphin-8, represent the first structural identification of a beta-casomorphin peptide from a body fluid.

Acute Disease↗
PubMedDate not supplied

Evaluation of diaphragm electromyogram contamination during progressive inspiratory maneuvers in humans.

The diaphragm electromyogram (EMGdi) is susceptible to contamination by non-diaphragm related electrical signals such as the ECG, electrode motion artifacts, and other sources of noise. It is difficult to distinguish between these contaminating signals and those that are representative of the non-contaminated EMGdi, especially during periods when the EMGdi amplitude is relatively small, as during mild contractions of the diaphragm. The aim of the present study was to evaluate how contaminating signals influence the EMGdi power spectrum center frequency (CF) during progressive inspiratory maneuvers. EMGdi and transdiaphragmatic pressure (Pdi) were measured via an esophageal electrode in eight patients with cervical cord injury performing inspiratory capacity (IC) maneuvers. The influence of the contaminating sources on CF was evaluated by two spectral deformation indices, one which is sensitive to both high and low frequency spectral deformation (omega index), and the other which is sensitive to high frequency deformation only (CF1000/CF500 index). The results indicated that EMGdi CF values scattered over a wide frequency range, particularly when the signals were obtained at Pdi levels less than 15% of Pdimax, or at lung volumes less than 30% of IC. When the spectral deformation indices were applied, the scattering in CF values was drastically reduced. This was expressed by a factor of 4 reduction in the coefficient of variation of the CF values. The majority of the excluded EMGdi signals (i.e. not satisfying the spectral deformation index inclusion levels), had low CF values mainly due to the presence of electrode motion artifacts. It was concluded that: 1) The majority of EMGdi power spectrums are deformed early on during unloaded inspirations, and their CF values should be carefully interpreted as being representative of diaphragm function. 2) The relative contribution of contaminating signals in the EMGdi decreases proportionally throughout the first two thirds of an inspiration to IC. 3) The use of visual inspection of the signal in the time domain is questionable as a method to discriminate non-contaminated signals. 4) Analysis of the signal in the frequency domain makes it possible to detect the influence of signal contamination.

Adult↗