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Biomedical subjects

L Lukanov

Publications and source records attributed to L Lukanov.

9 recordsLinked to original sources
PubMed1987

[The echographic histogram--its use in the diagnosis of diffuse liver diseases].

Quantitative evaluation of the echographic findings in patients with chronic liver diseases was carried out. 64 persons were examined--15 patients with liver steatosis, 21 patients with chronic hepatitis, 17 patients with liver cirrhosis and 15 healthy persons as controls. The diagnosis in all patients was confirmed by liver biopsy. With the help of the computer device of the echograph and by the same experimental conditions were measured: the mean echogenicity of a certain area (in units of density), the most frequent echogenicity and the maximal number of points with most frequent echogenicity. The analysis of the results showed that ultrasound examination allows the differentiation from the normal liver structure of the diffuse liver lesions (echogenicity above 20) and of liver steatosis (echogenicity above 26). The echographic histogram cannot differentiate chronic hepatitis from liver cirrhosis. This is possible by other echographic criteria.

Biopsy↗
PubMed1987

[Case report of Gaucher's disease].

The case of a 42 years old man suffering from Gaucher's disease is reported. The primary diagnosis was liver cirrhosis based on echographic and scintigraphic examinations. The following signs were found: thrombocytopenia, slight hemolysis, shortened life of the erythrocytes with considerable sequestration in the spleen, abnormal flocculation tests, increased acid phosphatase. The X-ray examination revealed irregularly oval light spots with different size and form and well cut outlines in the skull and a zone of bone resorption in the right shoulder joint. The liver needle biopsy showed parenchymal infiltration with Gaucher's cells. The above mentioned deviations and the family heredity of the patients suggested the diagnosis of an adult form of Gaucher's disease. The fibroplastic changes in the liver including formation of septa led to the suggestion of a link between Gaucher's disease and liver cirrhosis.

Adult↗
PubMed1981

Genome and chromosome mutations in porphyria cutanea tarda.

Spontaneous genome mutations in ten patients with porphyria cutanea tarda (PCT) amounted to 1.02% as compared to 0.36% in the control group of healthy individuals (P less than 0.01). Spontaneous structural chromosome aberrations in patients were seen in 2.39% of the examined cells versus 0.70% in the cells of controls (P less than 0.01). The increased percentage of cells with spontaneous genome and chromosome mutations in patients with PCT cannot be associated with alcohol only.

Adult↗