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L Lupi

Publications and source records attributed to L Lupi.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Value of double-contrast arthrography in the verification of meniscal pathology of the knee. Our experience].

The authors face the problem of accuracy, specificity and sensitivity of double-contrast arthrography in meniscal injury of the knee. They report the results obtained in a clinical-statistic and retrospective investigation on 206 patients. The final diagnoses were obtained by arthrotomy (105 cases) by arthroscopy (70 cases) and clinically with a follow-up of 6 months (31 patients). Diagnostic accuracy (94,5%), sensibility (92%), specificity (98,7%) and predictive values on positives (99%) and negatives (87,5%), confirm double-contrast arthrography as a highly accurate examination. A specific diagnosis can be made only when the diagnostic modalities are correctly applied and the arthrographers are qualified.

Arthrography↗
PubMed1984

[Intra-operative manometry and hiatal hernia].

Personal experience of the intra-operative use of oesophageal manometry in cases of hiatus hernia is presented. Using this system the pressure in the air cushion surrounding the L.E.S. can be adjusted to avoid any complications due to overtight or overlax surgery. Various types of post-operative tests confirm the value of the technique.

Esophagoscopy↗
PubMed1982

The pattern of thalassemia in Naples.

1. The expected number of patients with Cooley anemia in Naples, as predicted from heterozygote frequencies, is about 300 which is more than that found from hospital statistics. 2. Considering the presence of at least two beta-thalassemic alleles and the coexistence of a significant incidence of the Lepore gene in the population of the area surrounding Naples (the maximum incidence is thought to be in the neighboring province of Caserta), there are at least 6 different genotypes (3 true homozygotes and 3 genetic compounds) that can give rise to clinically important thalassemia syndromes, ranging from thalassemia intermedia to classic Cooley anemia. 3. Since an alpha-thalassemic gene is also present at polymorphic frequency in this population, this gene may coexist by random assortment in subjects who also have a beta-thalassemia syndrome, thus accounting for part of the variability of globin gene expression. 4. It is remarkable that 2 brothers homozygous for Hb Lepore present differences in the non-alpha/alpha ratio. The clinical differences could be explained by the gamma/alpha mRNA ratio close to 1 in one of them.

Child↗
PubMed1980

Genetic and biochemical heterogeneity of beta-thalassaemia in Naples.

We have investigated 32 children with Cooley's anaemia from Naples, Italy. Criteria for inclusion in the study were: (a) typical clinical and haematological findings; (b) absolute transfusion requirement; and (c) elevated Hb A2 in both parents. From biosynthetic studies we have established that five children (including two sets of sibs) had beta-0 thalassaemia, while the rest had beta + thalassaemia. Thus, the frequency of beta + thalassaemia among unrelated patients was about 90%. The distribution of beta/alpha ratios among beta + patients ranged from 0.01 to 0.16 and it was bimodal, consistent with some of them having a beta-0/beta + genotype and others a beta +/beta + genotype. The distribution of beta/alpha ratios of the patients' parents (obligate heterozygotes) ranged from 0.24 to 0.73, and it was plurimodal, consistent with the coexistence in this population of multiple beta thalassaemia alleles, of which one must be beta-0 and at least one is beta +. A systematic analysis of 20 families indicates that the beta/alpha ratio is to some extent quantitatively inherited, and its suggests non-randomness in the assortment of beta thalassaemia alleles that can give rise to a Cooley's phenotype.

Adolescent↗