Biomedical subjects

L M Bowman

Publications and source records attributed to L M Bowman.

12 recordsLinked to original sources

PubMed2001

Selective enhancement of systemic Th1 immunity in immunologically immature rats with an orally administered bacterial extract.

Infant rats primed during the first week of life with soluble antigen displayed adult-equivalent levels of T-helper 2 (Th2)-dependent immunological memory development as revealed by production of secondary immunoglobulin G1 (IgG1) antibody responses to subsequent challenge, but in contrast to adults failed to prime for Th1-dependent IgG2b responses. We demonstrate that this Th2 bias in immune function can be redressed by oral administration to neonates of a bacterial extract (Broncho-Vaxom OM-85) comprising lyophilized fractions of several common respiratory tract bacterial pathogens. Animals given OM-85 displayed a selective upregulation in primary and secondary IgG2b responses, accompanied by increased gamma interferon and decreased interleukin-4 production (both antigen specific and polyclonal), and increased capacity for development of Th1-dependent delayed hypersensitivity to the challenge antigen. We hypothesize that the bacterial extract functions via enhancement of the process of postnatal maturation of Th1 function, which is normally driven by stimuli from the gastrointestinal commensal microflora.

Adjuvants, Immunologic↗

PubMed1993

Pediatric coefficients for TRISS analysis.

We computed regression coefficients for TRISS analysis for all 4271 pediatric patients (aged 1 through 14 years) with complete data from the Major Trauma Outcome Study. We then compared predicted pediatric and adult TRISS survival probability norms. There were no statistically significant differences in the predicted and actual numbers of survivors using either norm. Differences in discrimination and reliability between the two norms were minimal. The study confirmed that the TRISS adult blunt norm is highly discriminating and reliable in predicting survival probabilities for pediatric patients. Given that both norms were equally good predictors, and the importance of a consistent system to evaluate trauma care, the authors recommend the continued use of the adult blunt trauma norm for estimating survival probability in children.

Adolescent↗

PubMed1991

Blunt trauma in children: significance of peritoneal fluid.

Seven hundred ninety consecutively seen children who had not undergone peritoneal lavage underwent imaging with computed tomography (CT) after blunt trauma. Collections of peritoneal fluid were prospectively characterized as small (51 children), moderate (32 children), or large (40 children). Associated injuries included hepatic or splenic injury in 74%, isolated renal or pancreatic injury in 5%, isolated pelvic fracture in 5%, isolated hollow viscus injury in 5%, and a combination of the above in 7%. Peritoneal fluid was the only CT abnormality in three children. A significant correlation was found between presence and increasing size of peritoneal fluid collections and clinical signs of hemodynamic instability such as lower trauma score (P = .0008 by analysis of variance), the presence of arterial hypotension (P = .0001 by chi 2 test), and hematocrit less than 30% (0.30) (P = .0001 by chi 2 test). Additionally, the presence and amount of peritoneal fluid correlated with need for laparotomy and with mortality (P = .0001 by chi 2 test for both).

Abdominal Injuries↗

PubMed1990

Parental attitudes and knowledge of child safety. A national survey.

The protection of children from injury ultimately depends on the actions of adults. We conducted a national telephone survey to assess parental attitudes and understanding of child safety. Parents worried more about kidnapping and drug abuse than about childhood injury. Although well informed about potential injuries to automobile occupants, parents knew little about dangers of pedestrian and bicycle injuries, burns, and drowning. Parents frequently mentioned "being careful" when describing precautions to reduce the risk of unintentional injury rather than mentioning proved safety measures. Parents of lower socioeconomic status demonstrated a more limited understanding of child safety. Physicians were cited as the parents' first choice for information on injury control and child safety. The parents' poor showing indicates (1) the importance of passive interventions and (2) the need for programs to increase parental knowledge of childhood injury and safety.

Accident Prevention↗

PubMed1990

Thoracic trauma in children: an indicator of increased mortality.

This study was undertaken to assess the significance of thoracic trauma as a marker of morbidity and mortality in children. During a 34-month period, 2,086 children younger than 15 years old were consecutively admitted to a Level I pediatric trauma center with blunt or penetrating trauma. For each child we prospectively recorded Trauma Score (TS), Injury Severity Score, (ISS), medical, and etiologic data. One hundred four children (4.4%) presented with thoracic trauma. The most common mechanisms of injury were pedestrian injury (36%), motor vehicle crashes (32%), and armed assault (12%). The most common injuries were pulmonary contusion (48%), pneumothorax, hemothorax, or pneumohemothorax (39%), and rib fractures (32%). Multisystem injury was present in 82% of the children. The mean TS and ISS were 11 and 27, respectively, significantly worse than scores for children without thoracic injury (15 and 7; P less than .0001). Seventy-one percent of the children were admitted to the intensive care unit, where they stayed an average of 6 days; 20% required surgery. The mortality rate was 26%. Injuries to the heart or great vessels had the highest mortality rate (75%), followed by hemothorax (53%), lung laceration (43%), and rib fracture (42%). Mortality for children with isolated chest injury was 5%, compared with rates of 20% for abdominal and chest trauma, 35% for head and chest trauma, and 39% for trauma to the head, chest, and abdomen. Less than 5% of the admissions to a pediatric trauma center incurred thoracic injury.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidents, Traffic↗

PubMed1990

Patterns of injury in children.

Trauma is the leading cause of death for children over 1 year of age. This study was undertaken to identify the patterns of injury among children admitted to a regional pediatric trauma center. During a 34-month period, 3,472 injured children were consecutively admitted to a regional pediatric trauma center. Data were collected on medical, etiological, and financial aspects of injury. Eight subgroups were defined by mechanism of injury: motor-vehicle crash occupants, pedestrian and cycle injuries, falls, child abuse, gunshot and stab wounds, burns, poisonings, and foreign body ingestions or aspirations. Analysis of variance, Duncan's multiple range test, and contingency table analysis were used to determine differences among subgroups of children. Blunt and penetrating trauma accounted for 64.3% of all admissions. The mean age of injured children was 5.5 years; 64% of the children were boys. Sixty-seven percent of the children were admitted directly from the scene of injury. One-way analysis of variance yielded significant differences in mean age, mean hospital length of stay (LOS), mean intensive care LOS, mean trauma score, mean injury severity, and mean hospital charges by mechanism of injury (P less than .01). The overall mortality rate was 2.4%. Child abuse, gunshot/stab wounds, and drowning had the highest mortality rates, but injuries to motor-vehicle crash occupants and pedestrians accounted for the greatest number of deaths.

Accidental Falls↗

PubMed1990

The lap belt complex: intestinal and lumbar spine injury in children.

The "seatbelt syndrome" describes intestinal and spinal injury caused by lap-style automotive restraints. More than 2,600 children were admitted to Children's National Medical Center with blunt injury in 3 years; 395 were involved in a motor vehicle crash. Ninety-five of the crash occupants (24%) were known to be wearing safety belts. Ten children sustained a "lap belt injury": five with lumbar spine injury, four with combined lumbar spine and intestinal injuries, and one child with intestinal injury. All ten children presented with a characteristic transverse abdominal ecchymosis. The CT scan was unreliable in evaluation of both spinal and intestinal injury. Lateral radiographs were required for definitive diagnosis in eight of nine children with lumbar spinal injury. CT scan was clearly diagnostic in only one of five children with intestinal injury. Children wearing lap belts are at risk of a "lap belt complex." Lateral spine X-rays, peritoneal lavage, and early laparotomy are recommended to establish an accurate diagnosis and to decrease morbidity.

Accidents, Traffic↗

PubMed1990

Rib fractures in children: a marker of severe trauma.

The early recognition of life-threatening injury is paramount to the prompt initiation of appropriate care. This study assesses the importance of multiple rib fractures as a marker of severe injury in children. We analyzed physiologic, etiologic, and injury data for 2,080 children with blunt or penetrating trauma aged 0-14 years consecutively admitted to a Level I pediatric trauma center. Analysis of variance, Student's t-test, and the Chi-square test of independence were used to test for differences between children with rib fractures and other children. Probability of survival was modeled using stepwise logistic regression. There were 14 deaths among 33 children with rib fractures, a mortality rate of 42%. Child abuse accounted for 63% of the injuries to children less than 3 years old, while pedestrian injuries predominated among older children. Children with rib fractures were significantly more severely injured than children with blunt or penetrating trauma but without rib fractures. When compared to children without rib fractures, children with rib fractures had a higher mortality rate, but no statistically significant difference in morbidity. The mortality rate for the 18 children with both rib fractures and head injury was 71%. A logistic model with variables measuring severity of head injury and number of ribs fractured correctly predicted survival in more than 85% of children with thoracic trauma. Although rib fractures are rare injuries in childhood, they are associated with a high risk of death. The risk of mortality increases with the number of ribs fractured. The combination of rib fractures and head injury was usually fatal.

Adolescent↗

PubMed1989

Trauma score versus revised trauma score in TRISS to predict outcome in children with blunt trauma.

We analyzed the accuracy of TRISS and a revised TRISS to predict survival outcome in a group of 1,562 consecutive children less than 15 years old admitted with blunt trauma to a pediatric trauma center. TRISS is an index that computes a probability of survival for each patient based on Trauma Score, Injury Severity Score, and age. R-TRISS uses the Revised Trauma Score instead of the Trauma Score. We used a statistical method based on TRISS and R-TRISS to compare patient outcomes from the pediatric study group with those of an adult baseline control group from the Major Trauma Outcome Study. Both TRISS and R-TRISS have the capability to accurately quantify survival outcome for children with blunt trauma; there was no statistical difference between the two methods to do so.

Adolescent↗

PubMed1989

A comparison of the trauma score, the revised trauma score, and the pediatric trauma score.

We compared the abilities of the Trauma Score (TS), the Revised Trauma Score (RTS), and the Pediatric Trauma Score (PTS) to retrospectively identify severely injured children. TS, RTS, and PTS were computed on admission for 1,334 consecutive blunt and penetrating trauma victims 0 to 14 years old. Injury Severity Score values of more than 15 and 20 or more were used as the criteria indicating severe injury. Sensitivity, specificity, and positive and negative predictive values were computed. Threshold values were determined for each scale to maximize sensitivity and specificity. No significant differences were found between the TS and the PTS. After adjusting for rapid respirations among children 0 to 3 years old, no differences existed between the RTS and the other scores. TS of less than 15, RTS of less than 12, and PTS of less than 9 are equally sensitive and specific indicators for pediatric prehospital triage. Because of the similarity of the instruments tested, their performances in other areas, such as quality assurance, should be considered when selecting a pediatric triage tool.

Adolescent↗

PubMed1988

Comparative outcomes of children and adults suffering blunt trauma.

In order to test the hypothesis that outcome from blunt traumatic injury is different for children and adults, a statistical method based on the TRISS Index was used to compare patient outcomes after blunt injury among three pediatric populations (N = 594 children: ages 0-3, ages 0-8, and ages 0-14) and an adult population (N = 7,809: ages 15-54 inclusive). There was no statistical difference in predicted outcome between these populations. Using a methodology that accounts for both anatomic injury description and physiologic response (TRISS), the survival probability function does not appear to be age dependent below 54 years.

Adolescent↗

PubMed1988

Outcome analysis of blunt injury in children.

A group of 1,009 children less than 15 years of age and consecutively admitted to a Pediatric Trauma Center was used to compare outcomes with the adult (15-54 yrs) MTOS norm population using TRISS. Four pediatric age groups (0-1, 0-3, 0-8, 0-14 yrs) formed the study groups. TRISS analysis resulted in no statistically significant difference in predicted outcome between any of the four pediatric groups and the adult baseline group. There were only seven misclassified children (0.69%) with respect to survival/death outcome, indicating the usefulness of TRISS to characterize pediatric blunt trauma. In addition, TRISS was used to delineate the injury severity mix of the pediatric population. A TS less than or equal to 14 and ISS greater than 15 was found to serve as a useful definition of severity in this group of injured children.

Adolescent↗