PubMed Health⌕ Search

Biomedical subjects

L M Deppisch

Publications and source records attributed to L M Deppisch.

At least 19 recordsLinked to original sources
PubMed1995

Endoscopically removed malignant colorectal polyps: clinicopathologic correlations.

BACKGROUND/AIMS: Treatment options for patients with endoscopically removed malignant colorectal polyps are polypectomy alone vs. polypectomy followed by surgery. The aim of this study was to define histopathologic parameters that can be used for clinically relevant treatment decisions. METHODS: Five pathologists evaluated 140 polyps for the presence or absence of unfavorable histology. Unfavorable histology was tumor at or near (< or = 1.0 mm) the margin and/or grade III and/or lymphatic and/or venous invasion. Adverse outcome was recurrent and/or local cancer and/or lymph node metastasis. RESULTS: Adverse outcome was 19.7% (14 of 71), 8.6% (2 of 23), and 0% (0 of 46) when unfavorable histology was present, indefinite (lack of agreement), and absent, respectively (P < 0.0005, present vs. absent). Four patients with cancer > 1.0 mm from the margin had an adverse outcome (2 with lymphatic invasion and 2 indefinite for lymphatic invasion). Four patients with negative resections later developed distant metastases. Eight patients (6.3%) died of disease, and 2 of 69 without unfavorable histology (both indefinite for lymphatic invasion) had an adverse outcome. Interobserver strength of agreement was substantial to almost perfect for margin, grade, and venous invasion and fair to substantial for lymphatic invasion. CONCLUSIONS: This system is usable clinically. Patients with unfavorable histology are probably best managed by resection postpolypectomy, whereas in the absence of unfavorable histology, they probably can be treated by polypectomy only.

Colonic Polyps↗
PubMed1995

Hormone-dependent, aggressive angiomyxoma of the vulva.

BACKGROUND: Aggressive angiomyxoma is a rare neoplasm of undetermined etiology that occurs mainly in the female vulva and perineum. It tends to recur but does not metastasize. This case report describes findings suggestive of the possible hormone dependency of this neoplasm. CASE: A 41-year-old gravid woman developed an aggressive angiomyxoma of the left vulva with growth apparently related to the length of the pregnancy. The neoplasm marked strongly for progesterone receptors by immunohistochemical methods but was estrogen-receptor negative. CONCLUSION: The growth of the neoplasm during pregnancy and the nuclear-positive staining for progesterone receptors suggest a possible hormone (progesterone) dependency for at least some cases of aggressive angiomyxoma.

Adult↗
PubMed1989

Gastric epithelial polyps. A 10-year study.

We have reviewed the 10-year experience of a community teaching hospital with gastric epithelial polyps and have analyzed 121 polyps removed from 35 patients. Hyperplastic polyps constituted nearly 75% of the polyps examined; fundic gland polyps constituted 17%, and adenomatous polyps were infrequent (8.6%). No clinical or endoscopic finding distinguished the variants of polyp before histologic examination. The majority of hyperplastic and fundic gland polyps were multiple. Whenever there were multiple polyps, all polyps were of the same histologic type. In no case did adenocarcinoma originate within a benign polyp. In only a single case was there an associated adenocarcinoma elsewhere in the stomach. None of the adenomatous polyps was linked with gastric adenocarcinoma.

Adult↗
PubMed1989

Gastric xanthelasma in hyperplastic gastric polyposis.

Hyperplastic polyps of the stomach are uncommon, while xanthelasma of the gastric mucosa has a variable reported frequency. The frequency of both lesions appear increased in association with chronic gastritis and previous gastrointestinal anastomosis. The present article consists of a case report that documents for the first time (to our knowledge) the coexistence of these two lesions in a patient with a history of erosive gastritis.

Aged↗
PubMed1983

Cervical melanosis.

The third case of melanosis of the exocervix reported in the English literature is presented. Discovery was incidental at surgery for unrelated findings. The pathogenesis of melanosis is unknown, but the lesion apparently is innocuous. Biopsy should distinguish this entity from other pigmented lesions of the cervix, eg, malignant melanoma and blue nevus.

Female↗
PubMed1977

Squamous cell carcinoma of the urachus.

The third documented case of primary squamous cell carcinoma of the urachus in the English literature is reported. The interesting coincidental occurrence of the dermoid cyst of the right ovary and a complete longitudinal septum of the vagina and uterine cervix is described.

Autopsy↗
PubMed1977

Cytomegalovirus oophoritis: ovarian cortical necrosis.

Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are distinctive macroscopically, pathognomonic microscopically, and characterized by acute focal ovarian cortical necrosis with numerous cytomegalic cells and a variable but usually severe inflammatory reaction. It is suggested that reduced ovarian cortical vascular perfusion reactivates a latent infection in cortical stromal cells. This elicits inflammatory necrosis and the characteristic morphological lesions. This previously unreported lesion is not likely to have clinical importance.

Adult↗
PubMed1977

Coronary embolism and myocardial infarction associated with nonbacterial thrombotic endocarditis.

Six cases of coronary embolism and myocardial infarction associated with nonbacterial thrombotic endocarditis were seen at the Mount Sinai Hospital over a ten-year period. Every patient had an underlying malignant neoplasm. The vegetations were found on aortic, mitral, tricuspid and pulmonic valves and were located on the free or closure margins. The clinical diagnosis of this condition is difficult because of simultaneous embolization to the brain, causing widespread neurologic symptoms, but could be made by electrocardiographic and serum enzyme studies. Myocardial infarction caused the deaths of three patients. The relationship between nonbacterial thrombotic endocarditis, hypercoagulability, and disseminated intravascular coagulation is discussed.

Adult↗
PubMed1976

Non-bacterial thrombotic endocarditis: clinicopathologic correlations.

Sixty-five cases of nonbacterial thrombotic endocarditis (NBTE) were discovered at autopsy during a 10 year period--an incidence of 1.6 per cent in the adult autopsy population. In 51 cases, one or more malignant neoplasms were associated; adenocarcinoma represented the most frequent histologic type of related neoplasm. Coagulation abnormalities suggestive of disseminated intravascular coagulation (DIC) were present in 18.5 per cent of the cases. It is possible that both the valvular and peripheral intravascular thromboses in at least some cases of NBTE represent the abnormal coagulation of DIC. Arterial thrombosis with infarction occurred in many peripheral organs. Splenic and renal were most frequent, but cerebral and cardiac consequences were the most significant.

Adult↗
PubMed1975

Myocardial infarction due to coronary atherosclerosis in three young adults with systemic lupus erythematosus.

Three patients, 24, 24 and 25 years of age, with systemic lupus erythematosus had signs of myocardial infarction. Two had serial electrocardiographic changes indicative of infarction without any cardiac symptoms. The third patient had clinical evidence of an acute massive myocardial infarction, which was proved at autopsy to be due to coronary atherosclerosis. This case is presented in detail and the association between systemic lupus erythematosus and myocardial infarction is reviewed. It is postulated that the relation between lupus erythematosus and coronary atherosclerosis is more than coincidental.

Adult↗
PubMed1975

Cysts of the vagina: Classification and clinical correlations.

The clinical and morphologic features, as well as the classification, of surgically excised cysts of the vagina were reviewed. Sixty-four cysts were available for study. Classification was principally along developmental grounds, based on histologic and histochemical features of cyst epithelium. Detection of epithelial mucus production reduced significantly the incidence of Gartner's duct (mesonephric) cysts, indicating that this is an uncommon lesion. Cysts of mullerian origin, lined mainly by endocervical and occasionally by fallopian tubal epithelium, comprised one-third of the cases. Inclusion cysts of surface mucosa constituted the most common, but usually a clinically insignificant, type of vaginal cyst. Dilation of paraurethral glands and ducts could not adequately explain all the several cysts lined by urothelium. These lesions were difficult to distinguish on clinical grounds, alone, although mullerian cysts were nor symptomatic, due to their greater size.

Adult↗