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L M DuBuske

Publications and source records attributed to L M DuBuske.

20 records · Page 2Linked to original sources

The link between allergy and asthma.

Patients with asthma and concomitant allergic rhinitis are among the most costly patients. A survey of over 34,000 patients with asthma indicated that the cost of those patients who have asthma alone without allergic rhinitis was roughly half the overall cost of patients who had concomitant allergic rhinitis and asthma. Asthma and allergic rhinitis are linked in several ways. The shared immunologic pathogenesis are nasal bronchial reflex, allergen sensitization, and epidemiologic studies that link asthma and allergy. There is an interrelatedness of the upper and lower airway function, the link operating directionally from the sinuses to the lungs. In addition, there is a co-occurrence of asthma and allergic rhinitis in the population. Furthermore, both conditions respond to similar treatments, including antihistamine-containing therapies that may ameliorate allergic rhinitis and also potentially help alleviate asthma symptoms.

Anti-Allergic Agents↗

Mediator antagonists in the treatment of allergic disease.

New approaches to allergic inflammation include specific cytokine antagonists and monoclonal antibodies against IgE, against chemokines, and against adhesion molecules. Currently available therapies, such as leukotriene antagonists, may soon be approved for allergic rhinitis. New generation antihistamines such as desloratadine have wide-ranging anti-allergic, anti-inflammatory profiles, including suppression of cytokine, chemokine, and adhesion molecule expression. Recent desloratadine studies have demonstrated that this highly potent H1 receptor antagonist consistently provides relief of nasal congestion and may provide benefits similar to montelukast in mild asthma patients. New generation intra-nasal corticosteroids such as fluticasone and mometasone provide high corticosteroid potency while being minimally bioavailable when administered as intranasal preparations. Future advances in allergy therapy also include improved T-cell selective formats of immunotherapy. The range of therapies for allergic rhinitis is likely to substantially increase in the coming years.

Anti-Allergic Agents↗