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Biomedical subjects

L M Holbach

Publications and source records attributed to L M Holbach.

58 records · Page 4Linked to original sources
PubMed1989

Neuroglial choristoma presenting as congenital lid tumor.

A 12-month-old boy presented with a diffuse solid tumor of the nasal portions of the lower lid, which had caused almost complete narrowing of the interpalpebral fissure since birth. Clinically, it was suspected to be a mesenchymal tumor. Radiological studies revealed no bony defects in the orbit. The computerized tomographic (CT) scan disclosed a porencephalic cyst in the ipsilateral cerebral hemisphere. Excisional biopsy of the lid tumor revealed ectopic neuroglial tissue. The immunocytochemical demonstration of glial fibrillary acidic protein (GFAP) was consistent with the electron microscopic findings that disclosed fibrillary astrocytes with an abundance of typical 9- to 10-nm glial filaments. Heterotopic neuroglial tissue should be part of the differential diagnosis of congenital lid tumors; its occurrence may be associated with other anomalies of cerebral organogenesis.

Biopsy↗
PubMedDate not supplied

Breast carcinoma metastatic to the eyelid presenting as the first sign of insufficient chemotherapy.

Metastatic eyelid tumors are uncommon. Their presentation may vary markedly. We describe a 61-year-old female who presented with a tender nodule in her right upper eyelid shortly after chemotherapy for metastatic disease. She had undergone right mastectomy and radiotherapy because of an adenocarcinoma 16 years ago. Histopathologic findings were consistent with metastatic carcinoma. Knowledge of the diverse clinical and histopathologic features of metastatic breast carcinoma to the eyelids is essential for the appropriate management of these patients. Breast carcinoma metastatic to the eyelid represented in this patient the only sign of insufficient chemotherapy.

Adenocarcinoma↗
PubMedDate not supplied

Biomolecular markers of malignancy in human uveal melanoma: the role of the cadherin-catenin complex and gene expression profiling.

In recent years there has been a trend towards conservative management of uveal melanoma (UM), aimed at preserving the eye and vision. Despite improvements with this approach, recurrent tumour and metastatic disease still occur, and the management remains problematic. As a result of these limitations, there is interest in gaining a greater understanding of molecular changes associated with aggressive disease patterns in UM. This might result in new, more effective and less toxic therapies as well as provide prognostic information for defining subgroups of patients with a less favourable prognosis as potential candidates for adjuvant therapies. Accumulating evidence over the past decade suggests that disturbance in the cadherin-catenin adhesion complex is critical in the process leading to invasion and metastasis of many cancers. The recent advent of DNA micro-array technology now offers an unprecedented ability to study these molecules and others associated with malignant transformation. In this mini-review, the aspects of tumour progression in which cadherin-catenin may be involved are dealt with along with the potential application of DNA micro-array technology to the problem in UM.

Biomarkers, Tumor↗