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Biomedical subjects

L M Jampol

Publications and source records attributed to L M Jampol.

At least 163 records · Page 9Linked to original sources
PubMed1979

Subretinal neovascularization with geographic (serpiginous) choroiditis.

Three patients with geographic choroiditis developed subretinal neovascular membranes associated with subretinal hemorrhage and serous elevation of the retina. Proximity of the membrane to the foveal avascular zone prevented photocoagulation of the neovascular membrane in one patient. Central visual acuity remained 6/60 (20/200) despite systemic corticosteroid therapy. The neovascular membranes in the other two patients were obliterated by argon laser photocoagulation with preservation of central vision. The inflammatory process of geographic choroiditis can disrupt Bruch's membrane, allowing occasional choroidal vascular growth. Concomitant destruction of choroidal vessels may account for rarity of subretinal neovascularization in geographic choroiditis.

Aged↗
PubMed1979

Cryotherapy of proliferative sickle retinopathy, II: triple freeze-thaw cycle.

Complete closure of retinal neovascularisation due to proliferative sickle cell retinopathy was achieved in 28 'sea fans' (areas of neovascularisation) in 9 eyes of 9 patients by means of a triple freeze-thaw technique. However, 2 eyes developed subsequent rhegmatogenous retinal detachments, presumably related to vitreous traction on necrotic retina. We therefore recommend photocoagulation as the best treatment of proliferative sickle cell retinopathy. If opacities in the media prevent photocoagulation, a single freeze-thaw cycle is preferable.

Adolescent↗
PubMed1979

Vascular opacification and leakage in X-linked (juvenile) retinoschisis.

A 22-year-old man had X-linked retinoschisis with extensive vascular sheathing in the posterior pole and dendritic opacified retinal vessels in the periphery. Detailed fluorescein angiographic studies were performed. In the far periphery areas of capillary nonperfusion were seen. Sluggish circulation was present in the majority of dendritic opacified vessels in the areas of schisis. Late staining of the disc and posterior arteries and veins was noted. Scattered intraretinal fluorescein leakage was present even in clinically nonschitic retina, which suggests that the vascular changes may precede the retinoschisis. The patient's half-brother also had X-linked retinoschisis, but the schisis and the vascular changes were much less prominent. Although the retinal vascular changes with X-linked retinoschisis are similar to those seen with the Favre-Goldmann syndrome, a differentiation of the two diseases can be made by family studies, the presence or absence of nyctalopia, examination of the macular areas, measurement of dark adaptation, and electroretinogram determinations.

Adult↗
PubMed1979

Sickled erythrocytes, hyphema, and secondary glaucoma: III. Effects of sicle cell and normal human blood samples in rabbit anterior chambers.

When injected into rabbit anterior chambers, human sickle cell erythrocytes cause more intense and prolonged effects than do nonsickling erythrocytes. The consequences of injected sickle cell trait erythrocytes are not less severe than those of injected SC, SS, and Sthal erythrocytes. Regardless of hemoglobin composition, blood with a higher hematocrit value causes more severe complications than blood with a lower hematocrit value.

Anemia, Sickle Cell↗
PubMed1978

The disc sign in sickling hemoglobinopathies.

The disc sign is the presence of dark red spots on the optic disc of patients with a sickling hemoglobinopathy. The dark spots appear to be plugs of deoxygenated erythrocytes in small surface disc vessels. The occlusions, which are transient and do not produce clinically detectable visual impairment, were seen most often in patients with homozygous sickle cell anemia and may be the result of clogging of small vessels by irreversibly sickled erythrocytes.

Adolescent↗
PubMed1978

Amelanotic small flat lesions of the choroid.

On routine examination, three patients demonstrated yellow-white lesions in the posterior third of the fundus. These lesions have a subtle but unique appearance. They are in the choroid and have definite borders, minimal or no elevation, a lack of secondary changes in the overlying pigment epithelium or neuroepithelium, and no pigment within the lesion or at its borders. Ophthalmoscopic and fluorescein angiographic data permit discussion of the differential diagnosis of these lesions. They may represent amelanotic nevi of the choroid.

Adolescent↗
PubMed1978

Peptostreptococcal endophthalmitis with a relapsing course.

A posttraumatic exogenous endophthalmitis developed that was due to Peptostreptococcus. This Gram-positive anaerobe was isolated in pure culture from vitreous. The endophthalmitis showed a bacteriologic and clinical relapse despite conventional routes of antimicrobial treatment. A second clinical relapse occurred despite apparent vitreal sterilization with intravitreal antibiotics. The response to vitrectomy was impressive, and postoperatively the patient's visual acuity improved to 20/20.

Adolescent↗
PubMed1978

Systemic hypotension and glaucomatous changes.

We undertook a prospective study to determine the frequency of development of glaucomatous disk or field changes in a series of patients who had survived at least one episode of shock with poor peripheral tissue perfusion. In 18 patients with 26 distinct episodes of shock we were unable to demonstrate any glaucomatous disk or field changes.

Adult↗
PubMed1978

Therapy of scleritis with cytotoxic agents.

Four patients with severe anterior scleritis that had not responded to conventional therapy were treated with cytotoxic immunosuppressive alkylating agents alone (one case) or in combination with prednisone (three cases). Two of the patients had Wegener's granulomatosis, one pyoderma gangrenosum, and one rheumatoid vasculitis. All patients responded well to this therapy with a decrease in inflammation and a healing of the sclera. Other systemic manifestations of the underlying diseases often responded well also.

Adult↗
PubMed1978

Carotid artery disease and glaucoma.

Five patients with evidence of severe bilateral carotid artery disease and increased intraocular pressure have been followed up for 3 to 12 years without the development of glaucomatous disc or field changes. Although it is frequently stated that glaucoma patients with low systemic or ophthalmic artery blood pressures show rapid progression of their eye disease, our patients show that this is not necessarily true. Other more important and largely unknown susceptibility factors determine the occurrence of glaucoma in patients with raised intraocular pressure.

Carotid Artery Diseases↗
PubMed1977

Leber's congenital amaurosis.

An early stage of Leber's congenital amaurosis, characterized by white spots or lines in the fundus, occurred in two children. Light microscopic examination of eyes obtained from one child, a 16-month-old Japanese girl, revealed subretinal deposits corresponding to the white spots and lines in the fundus deposits. Light and electron microscopic examination of the eye showed distinctive changes in the outer retinal layers and choroid, while the inner retinal layers were nearly normal. Characteristic early lesions of congenital amaurosis appeared to be produced by deposits consisting of loose outer segments and apical processes of the pigmental epithelial cell and macrophages. Undifferentiation in the nuclei of the photoreceptor cell, the inner segment, the pigment epithelial cell, and the choriocapillaris were likely characteristics of the early changes of congenital amaurosis.

Blindness↗
PubMed1977

An unusual presentation of Best's disease.

We diagnosed an unusual case of Best's disease in a patient with multiple geographic macular and extramacular lesions. Initial confusion in the diagnosis arose because of a past history of intravenous drug abuse by the patient. The electro-oculogram was helpful in establishing the correct diagnosis.

Adult↗
PubMed1976

Active giant cell arteritis with cerebral involvement. Findings following four years of corticosteroid therapy.

A patient had continued active giant cell arteritis proved on biopsy four years after the initial diagnosis of temporal arteritis. The patient had had erythrocyte sedimentation rates within the normal range and had been receiving corticosteroids without interruption for four years. Central nervous system symptoms occurred three and four years after the initial diagnosis.

Aged↗
PubMed1976

Occlusive retinal arteriolitis with neovascularization.

A 34-year-old white woman who had used oral contraceptives for six years showed an occlusive bilateral retinal arteriolitis that resulted in a branch arteriolar occlusion in the right eye and retinal neovascularization. Three years later, we observed active arteriolitis in the left eye with successive occlusion of several branch arterioles. The disease has shown spontaneous remissions and exacerbations. An extensive medical evaluation revealed only old pulmonary granulomatous disease and an elevated sedimentation rate in association with exacerbations of the arteriolitis.

Adult↗
PubMed1976

Diagnostic features of the Favre-Goldmann syndrome.

Extensive retinal vascular disease was noted in three patients from two families with Favre-Goldmann syndrome. In addition to classical features they had pronounced leakage from some retinal vessels. Vessels were either opaque ('sclerotic') or non-perfused. Cystoid macular oedema was a contributing cause of decreased vision. Two of the three patients showed a discrepancy on electroretinography between single-flash photopic amplitudes and flicker fusion frequency. This may be characteristic of Favre-Goldmann syndrome.

Adult↗
PubMed1976

Pathways of the eye's response to topical nitrogen mustard.

We studied the effect of prior corneal herpes simplex infection with its resultant corneal hypesthesia on the irritative response of the rabbit eye to topical nitrogen mustard. Both the miosis and the breakdown of the blood-aqueous barrier that follow the application of topical nitrogen mustard were diminished in eyes infected three weeks previously with herpes simplex virus. Nonspecific corneal scarring did not affect the response. This suggests again that an axon reflex requiring intact sensory innervation mediates the response to nitrogen mustard. Pretreatment of normal (noninfected) rabbits with systemic H1 and H2 antihistamines, topical scopolamine hydrobromide, or topical and systemic corticosteroids was ineffective in blocking the miosis or increased protein in the aqueous humor following topical nitrogen mustard.

Adrenal Cortex Hormones↗