Biomedical subjects
Publications and source records attributed to L M Krylov.
A rare case of larynx malignant fibrous histiocytoma is presented. Histologically and ultrastructurally, the tumour was similar to malignant fibrous histiocytoma of other organs. The patient was followed up for 2 years after surgical treatment and preoperative irradiation. No recurrence and metastases were observed.
The paper describes two observations of thymus gland tumours: epithelial thymoma and seminoma. Differential diagnosis of these tumours is very important for the proper selection of the method of treatment as seminoma is more radio-sensitive than epithelial thymoma. Epithelial thymoma is characterized by coarse-fiber stroma, perivascular grouping of cell elements and the lack of glycogen in them. Seminoma consists of light and dark cells containing much glycogen in their cytoplasm. Differences between these tumours are most clearly seen in electron microscopic studies. In epithelial thymoma cells have processes, numerous tonofilaments, desmosomes, and basal membrane. Seminoma cells contain glycogen, no tonofilaments or basal membrane, few desmosomes.
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The results of electron microscopy studies of 20 soft tissue sarcomas difficult to diagnose-fibrosarcomas, malignant fibroxanthomas, leiomyosarcomas, rhabdomyosarcomas and malignant schwannomas, are reported. The tumor elements of each of these neoplasms showed rather typical ultrastructural features enabling us to reliably ascertain their histological origin.
Thirteen tumors of questionable genesis located in the thymus were studied. The microscopical structure of these tumors was identical to lymphogranulomatosis of other localization. Reactive proliferation of the thymic epithelium and cyst formation are characteristic of lymphogranulomatosis primarily developing in the thymus. The disease was not "granulomatous thymoma" since giant multinuclear cells by their structural characteristics corresponded to reticular elemens and the epithelial component was absent in extrathoracal formations.
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Electron microscopic study of leiomyoma of skin arteries, oesophagus leiomyoma, leiomyosarcoma and rhabdomyosarcoma was carried out. In the tumor cells myofilaments were found sometimes forming hexagonally packed myofibrilles, formations resembling desmosomes. This permitted the establishment of valid myogenic histogenesis of these neoplasias.
The paper describes 12 cases of spindle cell thymoma without myasthenia or any other syndromes such as hypogammaglobulinemia, hypoplasia of the red sprout of the bone marrow. In most patients the tumours were detected roentgenologically. Microscopic diagnosis of spindle cell thymoma is based on the detection in it of epithelial cell structures. In those cases where the tumours were represented by spindle cells alone, verification of the tumor was possible only by electron microscopic studies (the presence in the cells of tonofilaments, desmosomes and basal membrane).
An electron-microscopy investigation of two fibrosarcomas was carried out. Blastomatous elements were represented by fibroblasto-like cells. In their cytoplasm there were observed phaged fragment of collagenic fibrils, and in small canals of the granular endoplasmic reticulum--crystalloid formations. Diagnostic significance of these findings is discussed.
Electron microscopic examinations of two malignant fibroxanthomas revealed some ultrastructural features characteristic of this tumor. The tumor elements were represented by histiocyte-like, fibroblast-like and little differentiated cells. In some of the latter the signs of macrophage differentiation could be seen and therefore a possibility of their transformation into histiocytes is assumed.
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