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Biomedical subjects

L M Lewkow

Publications and source records attributed to L M Lewkow.

7 recordsLinked to original sources
PubMed1992

Cardiac complications of intensive dose mitoxantrone and cyclophosphamide with autologous bone marrow transplantation in metastatic breast cancer.

Fifteen women with metastatic breast cancer undergoing autologous bone marrow transplantation were treated with an intensive induction regimen including cyclophosphamide and mitoxantrone in a phase I-II study. The cardiotoxicity of these two drugs in combination have not been previously reported. Three patients developed deeply inverted T-waves during or shortly following conclusion of high-dose chemotherapy with associated declines in ejection fraction of 0.04, 0.19 and 0.27. One patient developed a brief episode of congestive heart failure which resolved with supportive care. These three patients were the only ones to have received previous left chest wall radiotherapy during the course of their disease, prior to treatment with autologous bone marrow rescue. No patient developed dysrhythmia or QRS changes during a mean hospital stay of 33.7 days (range 27-40 days).

Adult↗
PubMed1988

Sickle cell E hemoglobinopathy and pregnancy.

The incidence of E hemoglobinopathies has been increasing in the United States. This is the first known case report of hemoglobin S/E in pregnancy. Management was based on the similarities of the S/E and S/beta-thalassemia hemoglobinopathies, and included partial exchange transfusion. Complications included fetal distress, congenital hydrocephalus, and cleft lip and palate. It appears that S/E and E/beta-thalassemia hemoglobinopathies may entail increased perinatal risks, but that favorable pregnancy outcomes may be anticipated with homozygous hemoglobin E or hemoglobin E trait.

Adult↗
PubMed1986

A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis.

We have recently completed a double-blind, placebo-controlled, noncrossover study, the goal of which was to determine whether cetiedil citrate (cetiedil) could affect the course of vaso-occlusive crises in sickle cell disease. Patients, who presented to the emergency room at least 4 but no more than 24 hours after the onset of a painful vasoocclusive crisis severe enough to require hospitalization, were considered candidates for the study. Each patient received either placebo or cetiedil at one of the following three dosages: 0.2, 0.3, or 0.4 mg/kg body weight. The assigned drug dosage was given as a 30 minute intravenous infusion every 8 hours for 4 consecutive days. A total of 67 patients was enrolled in the study. Cetiedil, at its highest dosage (0.4 mg/kg body weight), was found to be significantly superior to placebo both in reducing the number of painful sites present on all 4 treatment days and in shortening the total time in crisis. No serious adverse reactions were observed during the course of the study. We conclude that cetiedil, given at a dosage of 0.4 mg/kg body weight, is therapeutically advantageous for sickle cell crisis.

Adolescent↗
PubMed1984

Sickle cell anemia and epidural extramedullary hematopoiesis.

Acute flaccid paralysis due to epidural extramedullary hematopoiesis developed in a 43-year-old man with sickle cell anemia. The patient showed no response to emergency decompressive laminectomy, radiotherapy, or exchange transfusion, and his neurologic deficit persisted unimproved. This is the first reported case of acute or irreversible spinal cord compression due to epidural extramedullary hematopoiesis in a patient with sickle cell anemia.

Adult↗
PubMed1984

Acute basophilic leukemia.

Acute basophilic leukemia was diagnosed in a 61-year-old black woman on the basis of 85 to 90 percent basophils in the peripheral blood as well as bone marrow and very high serum histamine level (more than 10,000 ng/ml). These complications occurred as a transformation from essential thrombocythemia. Accompanying this transformation, there was also cytogenetic change from 46XX karyotype to 46XX 2p+ in 66 to 90 percent of cells in the bone marrow. This may be the first reported occurrence of transformation of essential thrombocythemia into acute basophilic leukemia.

Acute Disease↗
PubMed1983

Correlation of hypercupremia with other acute phase reactants in malignant lymphoma.

Levels of copper, haptoglobin, fibrinogen and Factor VIII were measured in 30 patients with non-Hodgkin's lymphoma on 90 occasions in an attempt to demonstrate a possible correlation between hypercupremia and other acute phase reactants. The four parameters were measured simultaneously in active disease and in remission. The serum copper, along with other parameters, was significantly elevated in the active disease (P less than 0.001) and there was a high correlation between the levels of serum copper, fibrinogen and haptoglobin (P less than 0.001).

Adult↗