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Biomedical subjects

L M McNiesh

Publications and source records attributed to L M McNiesh.

16 recordsLinked to original sources
PubMed1991

Evaluation of biodegradable ampicillin anhydrate microcapsules for local treatment of experimental staphylococcal osteomyelitis.

Successful treatment of chronic osteomyelitis requires sustained high concentrations of antibiotics locally within the infected bone. The efficacy of biodegradable (poly-DL-lactide-co-glycolide) microspheres containing 30.7% ampicillin anhydrate for the local treatment of experimental staphylococcal osteomyelitis was evaluated in rabbits. In the initial experiment, antibiotic therapy was initiated immediately following injection of Staphylococcus aureus into the proximal tibial metaphysis. A single intramedullary injection of microencapsulated ampicillin (100 mg) prevented osteomyelitis in all seven animals tested and was as effective as a two-week course of parenteral ampicillin administration. When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy. When antibiotic therapy was delayed for seven days and was preceded by debridement, all ten animals treated locally with microencapsulated ampicillin had sterile bone cultures. In contrast, seven of ten animals treated locally with unencapsulated ampicillin powder developed osteomyelitis. Biodegradable antibiotic-loaded microspheres may be of clinical benefit for the local treatment of chronic osteomyelitis.

Ampicillin↗
PubMed1989

Injury pattern aboard the USS Enterprise.

A retrospective analysis of the radiographic records of 1653 sailors aboard the USS Enterprise was performed during the author's recent reserve assignment. For the period 1985 to 1987, 102 radiographically recognizable injuries were discovered in the study group. The high rate (53.9%) of hand injuries aboard ship typifies that of a wage-earning population (age 20 to 50). However, analysis of the fracture pattern in the hand indicates that many of the most frequently encountered hand injuries may be preventable. Since the rates of anterior shoulder dislocation and gamekeeper's thumb may also be increased, initiating the necessary investigation and control measures for these injuries seems warranted.

Arthrography↗
PubMed1987

Unique musculoskeletal trauma.

Pelvic and lower extremity insufficiency fracture in the osteoporotic individual, an approach to posttraumatic wrist instabilities, and certain upper and lower extremity pediatric fractures are discussed. The case material concentrates upon the clinical/radiographic recognition of subtle trauma and the multimodality approach to these unique traumatic musculoskeletal conditions. The impact that computed tomography has had on some of these traumatic conditions also is presented.

Forearm Injuries↗
PubMed1986

Radionuclide bone scanning in giant cell tumor.

Radionuclide bone scan findings are described and correlated with pathology in 23 patients with giant cell tumor (GCT) of the bone. The degree of radionuclide activity was markedly increased in 20 (87%), minimally increased in three (13%), and decreased in none of the patients. Of the 23 patients with increased radioactivity, the pattern was diffuse in 11 (48%) and doughnut in 12 (52%). Extended patterns of radioactivity were present in 19 of 22 patients; however, none were associated with true tumor extension. Bone scanning did not aid in the detection of GCT, was nonspecific, and did not differentiate benign from malignant GCT. Although radioactivity extended beyond the radiographic abnormality in the majority of patients, this was most likely secondary to other bony abnormalities or local and/or regional hyperemia, and caution should be taken in ascribing this extension to either tumor or metastasis.

Adolescent↗
PubMed1983

Cadaver radiography in the teaching of gross anatomy.

The authors describe a new teaching method for first-year medical students, involving preparation and use of cadaver radiographs in the gross anatomy laboratory. A standard series of radiographs of each cadaver was obtained prior to dissection and provided to each group of students. This technique offers a unique opportunity for radiographic/anatomical/pathological correlation, facilitates an understanding of complex anatomical relationships, and illustrates the application of anatomical knowledge to clinical practice. It can also generate intense student enthusiasm and improve student-faculty communication and teaching relationships.

Anatomy↗
PubMedDate not supplied

A prospective comparison study of double contrast computed tomography (CT) arthrography and arthroscopy of the shoulder.

Thirty consecutive patients who underwent double contrast CT arthrography prior to shoulder arthroscopy were prospectively studied. Results from both studies were recorded with the radiologist blinded to the arthroscopic findings when making the final CT reading. The sensitivity, specificity, and accuracy, respectively, of CT arthrography findings compared to arthroscopy were 50%, 100%, 96% for rotator cuff; 66%, 100% 96% for bicipital labral complex; 100%, 100%, 100% for loose bodies; 50%, 100% 93% for Hill-Sachs lesions; 90%, 73%, 83% for anterior labral defects; and 100%, 100%, 100% for posterior labral defects. We conclude that shoulder arthroscopy accurately delineates abnormalities of the anterior and posterior labrum, bicipital labral complex, rotator cuff, joint synovium, and humeral head. CT arthrography accurately delineates capsular redundancy, loose bodies, hardware around joints, and bony glenoid rim abnormalities.

Adolescent↗