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Biomedical subjects

L M Mentkevich

Publications and source records attributed to L M Mentkevich.

12 recordsLinked to original sources
PubMed1977

The course of influrenza infection in mice with graft-versus-host reaction.

The course of influenza infection in mice with a developed graft-versus-host reaction (GVHR) was changed. Due to disturbances in the inflammatory process the pneumonia was delayed and less marked. Consequently, the infected mice died later than controls. Influenza virus reproduction in the lungs was more intensive and its persistence more prolonged. Interferon production in the lungs of mice with GVHR was similar to that in the controls.

Animals↗
PubMed1976

[Suppression of interferon synthesis during the "graft-versus-host" reaction in F1(CBAXC57BL/6) mice].

The development of the graft-versus-host reaction (GVHR) in the F1(1CBA X C57BL/6 hybrid mice after the transplantation of spleen cells from the C57BL/6 parent donor resulted in a strong inhibition of the serum interferon production induced by the intraperitoneal injection of the Newcastle disease virus. In vitro with the mouse bone marrow cells during the development of the GVHR the interferon response was first reduced and then disappeared completely. The described phenomenon could therefore serve as an index of the development of the GVHR.

Animals↗
PubMed1975

[Bone marrow interferon].

The nucleated cells of the bone marrow of mouse, rat, guinea pig, chick, cattle and humans proved to be capable of producing interferon in vitro following induction with the Newcastle disease virus. The production of interferon by these cells was characterized by high stability. The bone marrow interferon was not inferior in its activity to the corresponding interferon prepared with the blood leukocytes or splenic cells.

Animals↗
PubMedDate not supplied

[Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated mice].

Inoculation into irradiated (800--850 r) mice of syngeneic bone marrow cells treated with mRNA for interferon (mRNA-If) obtained from chick cells induced with UV-irradiated Newcastle disease virus was accompanied by the appearance in the blood of the animals of a substance with the properties of interferon, inhibiting the cytopathic effect of vesicular stomatitis virus in chick embryo cells but not in mouse L cells. Chicken interferon was detected in the blood of the experimental animals for 7--10 days after transplantation of mRNA-If-treated cells.

Animals↗
PubMedDate not supplied

[Interferonogenicity of the bacterial lysates in human and murine cell cultures].

The antibacterial JRS vaccine was found to be capable of inducing interferon production in human peripheral blood leukocytes and mouse bone marrow cells. The vaccine induced no interferon in L-929 cells or human diploid M-19 cells. Interferon appeared in the culture fluid within 4-6 hours after induction and reached the maximum levels in 18-24 hours. One-hour contact of the vaccine with leukocytes was sufficient for interferon induction. The interferon generated in human blood leukocytes was partially stable at pH 2.2; heating at 56 degrees C for 30 min reduced its activity 4-fold; antiserum to alpha-interferon inhibited it.

Animals↗
PubMedDate not supplied

[Potentiation of the antiviral activity of human interferons by virazole in in vitro experiments].

Combination of interferon and virazole results in potentiation of their antiviral activity. This was demonstrated with all three types of natural interferons and the recombinant RL-2-interferon. This effect is retained at a temperature of 37 degrees C and increases when the chemical drug is combined with a mixture of alpha- and gamma-interferon.

Dose-Response Relationship, Drug↗
PubMedDate not supplied

[Use of filter-adsorbed enterotoxins for isolating human immune interferon].

The use of A and B enterotoxins of St. aureus adsorbed on Millipore nitrocellulose filters for induction of donor blood leukocytes resulted in production of immune interferon free of the inducer. The interferon produced by this method is acid-labile and inactivated by antiserum to human immune interferon but not to human leukocyte interferon. The advantage of this type of induction consists in the possibility of multiple use of the filters with adsorbed enterotoxins.

Adsorption↗
PubMedDate not supplied

[Comparative study of interferon production in mice with the graft versus host reaction].

Mice with graft versus host reaction (GVHR) show a decreased production of serum interferon and that produced by the bone marrow and spleen cells and blood leukocytes in vitro upon inoculation with Newcastle disease virus. Interferon induction with lipopolysaccharide of Flexner bacteria resulted in activation of production of serum interferon and that induced in spleen cell and blood leukocyte suspensions. Serum interferon production after administration of poly(I) . poly(C) was similar in mice with GVHR and controls.

Animals↗
PubMedDate not supplied

[Human bone marrow interferon].

Bone marrow cells from suddenly dying people can produce interferon in response to incoulation of an inducer. The interferon obtained in bone marrow cells did not differ by its properties from the reference preparation. the lots of bone marrow interferon which had been prepared were not inferior in the antiviral activity to leukocyte interferon or were even superior to it. It is suggested that bone marrow cells be used for preparation of human interferon.

Bone Marrow↗