Methadone and edema.
We describe a patient on methadone maintenance who developed distal leg edema after years of treatment. The edema resolved when methadone was discontinued and recurred when it was restarted. This patient is compared to three others reported in the literature who also developed fluid retention shortly after being placed on methadone. We conclude that methadone induced edema can occur not only immediately, but also after years of uncomplicated treatment.
Adult↗