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Biomedical subjects

L M Overduin

Publications and source records attributed to L M Overduin.

9 recordsLinked to original sources
PubMed1997

[Lyme borreliosis in dogs].

In a 2-year-old Bernese Mountain dog the diagnosis of Lyme borreliosis was made, using the criteria that are mentioned in the literature: seropositivity in the presence of the typical clinical symptoms, with infestation of ticks in the history. The usual therapy of amoxycillin or tetracyclines was inadequate and did not resolve the clinical symptoms, possibly as a result of a combination of initial corticosteroid therapy, the clinical presentation of the disease (mainly meningitis), and a presumed immuno-incompetence often seen in this breed. Intravenous treatment with amoxycillin finally led to total cure of the disease. Lyme borreliosis recurred half a year later, presumably as a result of a new tick infestation. A review of the literature on Lyme borreliosis in humans and dogs is presented. The fact that Lyme borreliosis in dogs in the Netherlands has not been diagnosed often and has not been reported before may be due to differences in approach to human and canine patients with fever.

Ampicillin↗
PubMed1994

Effect of pericardiocentesis on circulating concentrations of atrial natriuretic hormone and arginine vasopressin in dogs with spontaneous pericardial effusion.

Factors regulating the secretion of atrial natriuretic hormone (ANH) and arginine vasopressin (AVP) have not been elucidated fully. In several studies the release of these peptides has been studied by inducing both increased atrial pressure and atrial distension. A few studies employ cardiac tamponade, allowing the effect of atrial pressure and atrial stretch to be studied separately. In eleven dogs with spontaneous cardiac tamponade the effect of pericardiocentesis on circulating concentrations of ANP and AVP was studied. Pericardiocentesis was followed by a prompt rise in (non-elevated) plasma ANH concentrations from 21.6 +/- 7.3 to 65.4 +/- 17.1 pmol/l (mean +/- SEM). The initially slightly elevated AVP concentration of 5.5 +/- 1.5 pmol/l declined following pericardiocentesis to 2.1 +/- 0.5 pmol/l. In three dogs the systolic arterial pressure was measured indirectly and the central venous pressure was measured with a fluid-filled catheter. Before and after pericardiocentesis arterial pressure readings did not change significantly. Central venous pressure values showed an immediate very steep significant decrease after centesis. It is concluded that ANH release is primarily regulated by stretch and not by atrial pressure, that plasma AVP concentrations are moderately elevated in cardiac tamponade and that in cardiac tamponade pericardiocentesis causes a rapid decline in plasma AVP concentration.

Animals↗
PubMed1993

[Status epilepticus or cluster epilepsy?].

Cluster seizures and status epilepticus may look similar but are to be treated differently. They have a totally different prognosis. During cluster seizures the daily dose of anti-convulsants is temporarily increased. Status epilepticus is treated with intravenous or rectal administration of diazepam combined with intramuscular or intravenous administration of phenobarbital. Two dogs with atypical status epilepticus are described.

Animals↗
PubMed1989

Pharmacokinetics of three formulations of diphenylhydantoin in the dog.

The pharmacokinetics of the sodium salt of diphenylhydantoin was studied in three healthy dogs, using three formulations, a capsule, a tablet and a suspension. The results were essentially the same for all three formulations. The serum half life after intravenous injection ranged from 3.1 to 3.6 hours before and 1.3 to 1.6 hours after a two-week period of oral treatment. The bioavailability of the formulations varied from 43 to 54 per cent. Serum levels likely to be required for canine therapy could not be maintained with any of the formulations used in this experiment.

Animals↗