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Biomedical subjects

L M Salkin

Publications and source records attributed to L M Salkin.

18 recordsLinked to original sources
PubMed1995

A Comparative study of ePTFE periodontal membranes with and without decalcified freeze-dried bone allografts for the regeneration of interproximal intraosseous defects.

A comparative study which evaluated two treatment modalities for regeneration of interproximal periodontal lesions was conducted. Eleven pairs of advanced periodontal lesions in 11 human subjects (6 male and 5 female) were treated in a split mouth design with expanded polytetrafluoroethylene (ePTFE) interproximal membranes alone (control) in one lesion and ePTFE interproximal membranes in combination with decalcified freeze-dried bone (test) in the other lesion. At 1 year post-treatment, both treatment modalities revealed a significant increase in clinical attachment levels from baseline (2.0 +/- 1.37 mm test, 2.0 +/- 0.88 mm control) with no significant differences between the two modalities. When the amount of new bone formed in these lesions was assessed using re-entry procedures, a significant difference in new bone formation from baseline was found only for lesions treated with ePTFE alone (0.4 +/- 0.78 mm test, 1.3 +/- 0.96 mm control). It was concluded that at 1 year post-treatment, significant clinical attachment gains could be obtained by the use of ePTFE barriers with or without DFDBA. Statistically significant results in bone fill were only found when ePTFE barriers were used alone.

Adult↗
PubMed1992

A 10-year longitudinal study of untreated mucogingival defects.

A study was conducted to observe the changes in areas with untreated mucogingival defects over a 10-year period. The results in this group after 4 years were previously published. Upon entering dental school, a group of 39 freshman dental students were assessed for plaque index, gingival index, probing depth, and width of keratinized gingiva in 112 sites of inadequate keratinized gingiva. Eighteen of the original 39 participants were reassessed for the same parameters in 64 sites after 10 years. The results revealed that 22 sites showed a slight increase in keratinized gingiva, 32 were unchanged, and 10 sites showed a slight decrease in keratinized gingiva. The mean width of keratinized gingiva at the beginning of the study was 1.73 +/- 0.542 mm and was 2.01 +/- 0.864 mm after 10 years. This represented a small, but statistically insignificant, increase in the width of keratinized gingiva. The Plaque Index and Gingival Index of this group at baseline and at 10 years indicated a high level of oral hygiene and gingival health. It was concluded that in the absence of gingival inflammation, areas with small amounts of keratinized gingiva may remain stable over long periods of time.

Dental Plaque Index↗
PubMed1991

Intraoral cytomegalovirus lesion and HIV-associated periodontitis in a patient with acquired immunodeficiency syndrome.

Exposure to cytomegalovirus (CMV) is common in persons infected with the human immunodeficiency virus. Autopsy studies have documented the presence of CMV in multiple organs, but CMV is seldom indicated as the causative agent in specific diseases. Few reports have described localized CMV infection in the oral cavity. This may be due to the occult histopathologic appearance during oral mucosal CMV infections and to a lack of awareness of CMV infection as a potential etiologic agent in nonspecific oral ulcerations and other oral disease entities. This report describes an intraoral ulceration with documented presence of a localized CMV infection in association with human immunodeficiency virus-associated periodontitis in a patient with acquired immunodeficiency syndrome. A causative relationship between these two entities, however, cannot be established or excluded.

Acyclovir↗
PubMed1990

Clinical evaluation of a biodegradable collagen membrane in guided tissue regeneration.

A bio-resorbable type I collagen membrane was investigated as a barrier for guided tissue regeneration. Ten human subjects with at least one pair of contralateral periodontal lesions with probing pocket depths of greater than or equal to 5 mm and radiographic evidence of greater than or equal to 40% bone loss were included. Each patient underwent contralateral surgical flap procedures. A collagen barrier was adapted to the tooth in the experimental defect and the flap replaced and sutured. The controls consisted of the same procedure without the placement of the barrier. Standardized measurements of change in probing attachment levels and fill of intrabony defects were obtained at the time of surgery and 1 year later at the time of surgical re-entry. The differences in change of probing attachment levels and amount of bone fill between individual test and control sites were compared utilizing the student's t-test for paired samples. The mean probing attachment gain in the test sites was 0.56 +/- 0.57 mm, and there was a mean probing attachment loss of 0.71 +/- 0.91 mm in the control sites (P less than 0.01). The gain of bone in test lesions was 1.16 +/- 0.95 mm, while no gain was observed in the control lesions (P less than 0.01). The results of this study demonstrated that sites treated with a collagen barrier comprised of cross-linked bovine Type I collagen exhibited significantly better healing as compared to control sites over the 1-year period of the study.

Adult↗
PubMed1987

A longitudinal study of untreated mucogingival defects.

A study was conducted to observe the changes in areas with untreated mucogingival defects over a 4-year period. Upon entering dental school, a group of freshman students were assessed for Plaque Index, Gingival Index, probing depth, and width of keratinized gingiva. These same students were reassessed for the same parameters at the end of their senior year. Of the 112 sites in 39 individuals, 33 sites revealed a slight increase in keratinized gingiva, 69 sites were unchanged, and 10 sites showed a slight decrease. These changes were minimal and not statistically significant. The Plaque Index, Gingival Index, and probing depth mean values showed a small but statistically significant improvement. In this group of students with a high degree of oral hygiene, areas with inadequate zones of attached gingiva were able to be maintained without further recession and without surgery.

Dental Plaque Index↗
PubMed1985

Collagen sponge as a topical hemostatic agent in mucogingival surgery.

Hemorrhage from palatal donor sites during periodontal mucogingival surgery was controlled by application of Collastat absorbable hemostatic sponges. The use of collagen sponges was evaluated in 20 free-graft cases. In contrast to microfibrillar collagen, which is normally delivered as clumps of material, a Collastat sponge was applied as a single piece that maintained structural integrity even when wet and was easy to maneuver into place. The highly porous sponges conformed to the wound, absorbed fluid and produced consistently reliable hemostasis with no secondary bleeding. By stemming the seepage of blood into the throat, patient safety and comfort were improved. The sponges were left on the wounds and removed at the 1-week postoperative visit, revealing well-formed granulation tissue. Healing proceeded normally with no evidence of infection, tissue reaction, or other adverse effects.

Collagen↗
PubMed1977

The occlusive competence of the duodenal orifice of the canine pancreatic duct.

Observations by scanning electron microscopy indicate that the mucosa of the terminal part of the major pancreatic duct of the dog is organized into numerous, highly convoluted folds. The individual mucosal cells are tall, columnar and studded with numerous microvilli. These folds are highly vascularized. The intraluminal administration of bethanechol and norepinephrine is associated with subsequent increases and decreases of mean opening pressures. Mean opening pressures were not observed to be associated with autonomic nervous activity that was unaccompanied by changes in systemic arterial pressure. It is concluded that the terminal portion of the canine major pancreatic duct probably acts as a passive valve, the occlusive competence of which is influenced by the status of the vasculature of the lining mucosa in this region.

Animals↗
PubMed1977

A cilia-bearing cell system in the intrahepatic bile ductules of the rat.

A scanning electron microscopic investigation of the luminal surface of the intrahepatic bile ducts of the rat has been performed using tissue prepared by critical point drying. Results of these studies have demonstrated that intrahepatic bile ducts of the rat are composed of cells, the luminal surface of which contains either microvilli or numerous long cilia. It was suggested that these cilia play an important role in tissue function, particularly in the propulsion of hepatic bile.

Animals↗
PubMed1976

The effect of a urea peroxide rinse on dental plaque and gingivitis.

The effectiveness of a commercially prepared oxygenating agent (Gly-Oxide Liquid) in reducing plaque accumulation and gingivitis was studied over a 3-week period. Sixty-nine dental students, ages 20 to 30, were divided into three groups: control (group I), placebo (group II), test formulation (group III). Subjects were scored using the Plaque and Gingival indices of Loe et al. at the beginning of the study and at 1, 2, and 3-week intervals. In accordance with a well-established experimental gingivitis model, oral hygiene was withdrawn for the duration of the study. No statistically significant differences in plaque development was noted. Analysis of variance showed a significant treatment effect on gingivitis (P less than 0.01). A significant difference between group I and group III was evident (P less than 0.05). The study indicates that the formulation may be effective in reducing gingivitis in human subjects. Additional investigations regarding its usefulness as a routine oral hygiene adjunct are warranted.

Adult↗
PubMed1975

A demonstration of microvilli on the luminal surfaces of epithelial cells of the canine extrahepatic biliary tract.

Micromorphologic evidence is presented which indicates that in the dog the lining epitheliums of the intramural portion of the common bile duct and proximal part of the cystic duct are organized into convoluted folds. The mucosal lining of the extramural portion of the common bile duct appears to contain simple crypt structures. The mucosal surface of the hepatic duct is characterized by parallel ridges, longitudinally aligned with the long axis of the duct. The epithelial cells of the entire canine extrahepatic biliary tree present a topographic-dome shaped appearance, and their luminal surfaces are densely covered with microvilli.

Animals↗