Biomedical subjects

L M Stannard

Publications and source records attributed to L M Stannard.

3 recordsLinked to original sources

PubMed1979

Morphological irregularities in Dane particle cores.

Electron microscopy of hepatitis B antigen has revealed Dane particles with abnormal morphology. These aberrant Dane particles contain incomplete cores. They were seen in large numbers in the serum of an HBsAg-carrying renal dialysis patient and were less numerous but invariably present in other Dane particle-containing sera --12 from asymptomatic carriers, 2 chronic hepatitis patients and 1 patient with acute hepatitis. All 16 sera were shown to contain HBeAg.

Antigen-Antibody Reactions↗

PubMed1977

Observations on the morphology of two rotaviruses.

The negative staining technique was used to study the morphology of two rotaviruses, the epizootic diarrizootic diarrhoea of infant mice (EDIM) and the simian virus SA II. It is proposed that the inner capsid of the virion has icosahedral symmetry and consists of 180 morphological units arranged in an open lattice formation with the 12 spaces at the apices being surrounded by 5 capsomeres and the other 80 spaces each surrounded by six capsomeres. The outer capsid of the virion consists of a honeycomb-like lattice which corresponds to the lattice arrangement of the inner capsid.

Animals↗

PubMed1976

Hepatitis B antigen: IgG components shown by immune electron microscopy.

Immune complexes could be formed with hepatitis B Ag and anti-IgG serum after treatment of the antigen with detergent, CsCl or glycerol, but not before. It is suggested that an antigenic determinant specifically reacting with anti-IgG forms an integral part of hepatitis B Ag. This determinant is ordinarily obscured in the undamaged antigen.

Antigen-Antibody Complex↗