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Biomedical subjects

L M Vavilova

Publications and source records attributed to L M Vavilova.

12 recordsLinked to original sources
PubMed1990

[Study of the complement system and the inhibitors of plasma proteolytic enzymes in the erythrocytes during blood preservation].

Changes in the activity of the complement system components C1--C5, and proteinase inhibitors: alpha 1-inhibitor, alpha 2-macroglobulin and antithrombin III were studied in red blood cell pack during storage at 4 degrees C, in comparison with erythroconcentrate. A decrease, detected in the level of C1, C3 and alpha 2-macroglobulin, was more pronounced in the erythroconcentrate than in the red blood cell pack. The data obtained have evidenced that the adequate amount of plasma plays an important role in the red blood cell preservation and prevention of accumulation of undesirable physiologically active substances in the transfusion solutions.

Antithrombin III↗
PubMed1990

[Serological markers of viral infections and various indicators of immunity in patients with hemophilia].

The authors have studied the incidence rate for markers of viruses of AIDS (HIV), hepatitis B (HBV) and cytomegalia (CMV), as well as certain parameters of antiinfectious defense in hemophilia patients. A high incidence rate of HBV and CMV markers was established in the investigated patients, and among them no seropositive subjects, by antibodies to HIV, were detected. In the presence of a low incidence rate of chronic HBsAg-carriership in this category of patients, a significant number of immune subjects was observed, that correlated with a relative stability of such immunity parameters as concentration of serum immunoglobulin G and the level of circulating immune complexes.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Indicators of nonspecific immunity in patients with hereditary hemochromatosis].

Parameters of nonspecific defence--complement protein function, circulating immune complex level, neutrophil phagocytic activity, completeness of the phagocytic reaction, C3c level, were evaluated in 162 carriers of hemochromatosis gene (114 homozygotes and 48 heterozygotes with respect to hereditary hemochromatosis) aged from 7 to 64 years. The analysis of the results obtained has permitted a conclusion that the suppression of the complement system function, according to the classic or alternative type, is associated with the disease pathogenesis--hyperferremia, and is caused by the damage of the immunocompetent organs and cells synthesizing individual proteins of the complement, as well as by infectious complications leading to hypocomplementemia with respect to separate components.

Adolescent↗
PubMedDate not supplied

[Syphilis as a chronic systemic infection].

During the last STDs'epidemic in Russia (1994 - 2004) over 2.7 min people have been infected with syphilis. At present the structure of syphilis morbidity is characterized by 37% of latent forms, including 1.5% late latency. The increased level of late latency may result from: an ever-growing number of those with asymptomatic syphilis; disorderly and self-dependent usage of antibacterial preparations; spread of the virus chronic infections (herpes, hepatitis B, C) altering the macroorganism immune response; alcohol and drug abuse which decreases the efficacy of specific therapy. In general, chronization of the syphilitic infection may be caused by antigenically inert treponemal cell surface; paucity of outer membrane protein; residence of treponemas within an immunoprotective niche; uncompleted phagocytosis of treponemes with macrophages. Syphilis remains an "infectio magna" and demands thorough attention to all diagnostic and therapeutic procedures on every stage of the disease.

Anti-Bacterial Agents↗