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Biomedical subjects

L M Veremenko

Publications and source records attributed to L M Veremenko.

7 recordsLinked to original sources
PubMedDate not supplied

[The characteristics of the information support for the process of the state accreditation of public health institutions in Ukraine].

Introduction of novel information technologies in the health system of Ukraine is a requisite condition of enhancing the effectiveness of work of medical bodies, ensuring high-quality medical care. Our objective in this study was to devise a mechanism of information support of the process of state accreditation of the public health institutions. A structural scheme is developed of a uniform information-analytical system for information support of the process of accreditation of medical institutions. An automated information system has been set up at the level of medico-prophylactic institutions, which consists of information-reference and information-analytical subsystems and provides information support for the process of accreditation. Ways are discussed of setting up an information-control system of accreditation using potentialities of the sectoral corporative computer network "Ukrmednet".

Accreditation↗
PubMedDate not supplied

[Succinate dehydrogenase and cytochrome oxidase activity in rat liver tissue under the influence of valexon].

The cytochrome oxidase and succinate dehydrogenase activities were studied in the liver supernatant fraction and homogenate of rats whom different amounts of valexon, organophosphoric pesticide with a hepatotoxic effect, were administered to. A significant increase in the enzymic activity in the supernatant fraction and the resulted rise in the value of the ratio of the activity in the supernatant fraction to that in the homogenate were found five days after a single administration of the preparation in a dose of 310 mg per 1 kg of body weight and after its three-month administration in a dose of 31 mg/kg. These changes may be believed to result from disturbances of the structural-functional state of the mitochondria due to penetration of valexon and its accumulation in them.

Animals↗
PubMedDate not supplied

[Swelling and contraction of rat liver mitochondria under the effect of hexachlorocyclohexane gamma-isomer and polychlorocamphene].

Swelling and contraction of the rat liver mitochondria were studied as affected by chloroorganic pesticides of hexachlorocyclohexane gamma-isomer (gamma-HCCH) and polychlorocamphene (PCC). Administration for two days of gamma-HCCH in a dose of 34 mg/kg and PCC in a dose of 48 mg/kg established to ccause swelling of the liver mitochindria in vivo, a decrease in their ability to swelling in KCl and KH2PO4 and to contraction with addition of ATP. When gamma-HCCH is administered daily for six months in a dose of 1.7 mg/kg the indices under study rise and in case of PCC analogous adninistration in a dose of 2.4 mg/kg-- the drop. The found differince in the effect of the mentioned preparations when they are introduced to the animal organism for a long time might be connected with singularities in their cumulative properties.

Adenosine Triphosphate↗
PubMedDate not supplied

[Activity of the indicator enzymes of liver subcellular structures with the prolonged administration of Valexon].

The free and unprecipitated activity of succindehydrogenase and glucose-6-phosphatase, as well as of that of glucose-6-phosphate-dehydrogenase in the rats liver was determined. The animals received for a long time (1--3 and 6 months) a new organophosphorus pesticide valexon (0.0-diethyl thiophosphoryl-oxyiminophenylnitryle acetate) by mouth in doses of 31 mg/kg and 3.1 mg/kg which corresponds to 1/20 and 1/200 LD50. The earliest changes (after 1 month) include: falling activity of hexokinase and a rise in that of glucose-6-phosphatase and succindehydrogenase, pointing to the damage of microsomes and mitochondria supervenes in 1 and 6 months time after introduction, respectively. The role of an early injury of microsomes and of disturbed first stages of glucose metabolism in the mechanism of the valexon action is suggested.

Animals↗