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Biomedical subjects

L M da Silva

Publications and source records attributed to L M da Silva.

At least 19 recordsLinked to original sources
PubMed2005

Herpes simplex virus type 1 shedding in the oral cavity of seropositive patients.

OBJECTIVE: Investigate the frequency of herpes simplex virus type 1 (HSV-1) reactivation in the oral cavity of seropositive patients with previous history of recurrent herpes labialis (recrudescent group) compared with those without any history of recrudescent lesions (asymptomatic HSV-1 infection). In addition, the relation between recrudescence and the presence of the virus in the saliva was assessed. MATERIALS AND METHODS: Fourteen individuals with previous history of herpes labialis (recrudescent group) and 11 HSV-1 seropositive asymptomatic volunteers were included in the study. Swabs were performed periodically in all subjects and the presence of HSV-1 DNA was identified by nested PCR. RESULTS: All the 25 subjects enrolled in the study, revealed at least one positive swab for HSV-1. The frequency of HSV-1 positivity in the group with recrudescent herpes labialis was not statistically different from the other group. Ten subjects of the recrudescent group presented with herpes labialis at least once during the study. CONCLUSIONS: HSV-1 shedding in the oral cavity occurs independently of herpes labialis recrudescence.

Adult↗
PubMed2004

Is HLA class II susceptibility to primary antiphospholipid syndrome different from susceptibility to secondary antiphospholipid syndrome?

To assess whether the major histocompatibility complex (MHC) profile of patients presenting with primary antiphospholipid syndrome (PAPS) is different from that of patients with secondary antiphospholipid syndrome (SAPS), we studied 123 patients, 34 of whom presented PAPS and 35 SAPS due to systemic lupus erythematosus (SLE), 54 SLE patients without antiphospholipid syndrome (APS), and 166 controls. HLA-DRB1 and DQB1 alleles were typed using amplified DNA hybridized with sequence-specific primers. Compared to controls, PAPS patients exhibited a nonsignificantly increased frequency of DR53-associated alleles, and SAPS patients presented an increased frequency of HLA-DRB1*03 alleles (corrected P = 0.05). In addition, HLA-DRB1*03 alleles were over-represented in SAPS patients presenting anticardiolipin antibody (aCL) (Pc = 0.02), in SLE patients as a whole (Pc < 0.0001), and in SLE patients without APS (Pc = 0.02). The frequency of aCL among SLE patients presenting or not HLA-DRB1*03 alleles was closely similar. A trend to an increase in the frequency of the DQB1*0604 allele (14.3 versus 4.2%, P = 0.03) and of the DQB1*0302 allele (31.4 versus 12.7%, P = 0.01) was observed in SAPS. Taken together, these results indicate that the association of SAPS with HLA-DRB1*03 is due to the association with SLE and is not due to aCL, and suggest that the HLA class II profile of PAPS is different from that of SAPS.

Adolescent↗
PubMed2001

[Care for the oncologic patient with chronic pain from the point of view of the nurse].

This study aims to understand how nurses interpret the care given to cancer patients with chronic pain. The informers were eight nurses from a public hospital. Data were collected on the basis of semi-structured interviews and the analysis identified three analytical categories: the evaluation of patients' pain, the importance of multidisciplinary care and nurses' difficulties to care for these patients. The results show that nurses have difficulties to care for such patients and need to update their specific knowledge related to cancer, chronic pain and its treatment as well as their skills to deal with emotions in order to promote adequate psychological support.

Adult↗
PubMed2001

[Self-care in hospital discharge planning after bone-marrow transplantation: a case report].

The purpose of this work was to construct an instrument that would enable the characterization of therapeutic self-care needs of an individual submitted to bone marrow transplantation (BMT) by reflecting on nursing interventions in the planning of hospital discharge based on Orem's self-care theory. The inclusion criteria consisted in the selection of allogenic clients who had been submitted to BMT and presented chronic myeloid leukemia. Data analysis enabled the evaluation of modified self-care requirements and nursing interventions were included in the support-education system and in the partly compensatory system. The instrument must be refined, but its use can be suggested as a support for the elaboration of the planning of hospital discharge for BMT patients.

Adolescent↗
PubMed2001

Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: correlation with CD4+ lymphocytes.

Lipid and acute-phase protein alterations have been described in various infection diseases, and they have been recorded during the early stages of HIV infection. Lipid and acute-phase protein profiles also have been correlated with cellular immunological abnormalities. To document these correlations during HIV infection, we studied 75 HIV-infected patients and 26 HIV-negative controls. Patients were classified according to the criteria proposed by the Walter Reed Army Institute: as WR-1 (CD4 lymphocytes, 1154 +/- 268/mm3), WR-2 (CD4, 793 +/- 348/mm3) and WR3/4 (CD4, 287+/-75 mm3). Triglycerides, total cholesterol and HDL-cholesterol concentrations were measured by enzymatic methods. Immunoglobulins (IgA and IgG) and acute-phase proteins (haptoglobin, alpha1-acid glycoprotein, C-reactive protein and transferrin) were determined by immunonephelometry. Haptoglobin levels were significantly increased in HIV-positive patients and correlated with the progression of HIV-infection (control<WR1<WR2<WR3/4). WR-2 and WR-3/4 patients had lower total cholesterol, HDL-cholesterol, and albumin concentrations, however, alpha1-acid glycoprotein and IgA levels were higher, when compared to HIV-negative controls. Elevated triglyceride levels (1.51+/-0.75 mmol/L) were found only in WR3/4 patients, when compared to the control individuals (1.05+/-0.04 mmol/L). No differences were found in transferrin and C-reactive protein concentrations among the studied groups. CD4+ lymphocyte counts were inversely correlated with triglycerides, IgA, alpha1-acid glycoprotein and haptoglobin, and they were positively correlated with albumin, total cholesterol and HDL-cholesterol. Multiple linear regression analysis showed that increased haptoglobin and IgA levels were the best predictive variables of a decreasing CD4+ lymphocyte count. In conclusion, our data showed that: 1) a decrease in total cholesterol, HDL-cholesterol and albumin levels occurred earlier than hypertriglyceridemia in the course of HIV infection; 2) increased levels of haptoglobin occurred earlier than that of alpha1-acid glycoprotein and IgA; 3) haptoglobin and IgA were the best predictive variables of a decreasing CD4+ lymphocyte count. Decreases in HDL-cholesterol and albumin levels with increases in haptoglobin, alpha1-acid glycoprotein, IgA, and triglycerides levels are indications of disease progression in HIV-infected patients.

Acute-Phase Proteins↗
PubMed2000

[Non-verbal communication; reflections on body language].

The present study aimed to reflect on the importance of body language through the identification of what a graduate nursing group knew about this topic. We analyzed the contents of reports from which five categories emerged: concept, function, importance, meaning and forms of body language manifestation. The group valued body language as a complex way of interpersonal interaction that sometimes occurs out of our control and of which we have little conscience. It has the function of expressing feelings, emotions and transmitting messages whose meanings are influenced by context. Body language knowledge increases our professional perception and it is one more instrument to improve nursing assistance quality.

Communication Barriers↗
PubMed1999

[Inequalities in mortality, space and social strata].

OBJECTIVE: A description of the mortality differentials in Salvador, Bahia, Brazil, is presented. METHODS: An ecological study was carried out. The city was divided into 75 information areas and its population into six social strata. Standardized Mortality Rates, Age Specific Mortality Rates, Proportional Infant Mortality and the Proportional Mortality Ratio were calculated for each region and social strata. Data were obtained from Death Certificates and the Populational Census. RESULTS: The mortality ratio difference between the strata with best living conditions and the poorer strata ranged from 43.1% to 142.0% which corresponds to an inequality ratio ranging from 1.4 to 2.4. When that analysis was carried out in smaller areas, these differences reached 656.3%. CONCLUSIONS: These findings show the persistence of health inequalities in Salvador in more serious disproportion than that found in other studies. Despite the methodological problems related to the nature of the data and the study, project the authors it was highlight, the meaning of this kind of research concerned with new approaches to health planning and health promotion.

Adolescent↗
PubMed1999

[Regional distribution of violence: mortality from external causes in Salvador (Bahia), Brazil].

The aim of this paper was to describe the geographic distribution of mortality resulting from external causes during 1991 within the city of Salvador, Bahia, Brazil. Mortality indicators were calculated in terms of deaths from external causes and in terms of specific types of violence. Of the deaths in that year, 15% were due to external causes, corresponding to a mortality rate of 78/100,000 inhabitants. The homicide death rate was 32.2/100,000 inhabitants, and the traffic-related death rate was 21.8/100,000 inhabitants. The elderly, young adults, and teenagers were at higher risk of death from violent causes. Among the elderly, 38% of the deaths were from car accidents and 28% from falls. Among teenagers, homicides were the main cause of death, especially in males between 15 and 29 years of age. Our results show that the geographic distribution of violent deaths in Salvador is uneven. Such deaths occur mainly in poorer neighborhoods, which have higher violent death rates than average for the city of Salvador. There is a need for prevention and control measures, including public policies and public health activities, focusing on the areas that have the greatest risk of death from external causes.

Adolescent↗
PubMed1998

[Teaching of nursing and the pedagogic trend. Short reflections].

This paper reviews important aspects about teaching nursing, in order to give nursing professionals an outline of the present pedagogical approaches (Traditional, Cognitivist, Behaviorist, Humanistic, Sociocultural), so that they can reflect upon their role as educators.

Education, Nursing↗
PubMed1996

Studies on the periodicity and intravascular distribution of Wuchereria bancrofti microfilariae in paired samples of capillary and venous blood from Recife, Brazil.

We examined the periodicity and intravascular distribution of Wuchereria bancrofti microfilariae (mf) and determined the effect of these parasite properties on the accuracy of blood filming and filtration methods for diagnosis of bancroftian filariasis in the endemic area of Recife, Brazil. Microfilariae in both venous and capillary blood exhibited a nocturnal periodicity pattern with a relatively high amplitude. Overall, capillary blood contained approximately 1.25 times the number of mf present at the same time in the same volume of venous blood. However, the ratio of mf present in capillary and venous blood varied over a 24-hour period, so that the fewest mf were present in the capillary bed of the skin at the time when biting activity of the local Culex vector is the lowest. Twenty or 60 microliters blood films did not reliably detect carriers with fewer than 100 or 60 mf/ml venous blood, respectively, and were thus inadequate for the identification of low density mf carriers. In contrast, all carriers with > 1 mf/20 or 60 microliters blood smear at night could be identified during daytime hours by filtration of 1 micromilligram venous blood.

Animals↗
PubMed1994

[Myocardial infarction in infective endocarditis].

Two patients with chronic valvular heart disease and myocardial infarction were assisted at our hospital. Both of them were febrile and only one had petechiae associated with signs of valvular involvement led to suspicion of infective endocarditis. Although blood cultures were negative, echocardiographic, surgical and anatomopathologic findings were compatible with infective endocarditis. They required cardiac surgery during the acute phase of the infection because they presented progressive hemodynamic deterioration and no satisfactory response to antimicrobial regimen too. One patient died at late follow-up (two weeks after the hospital discharge) and the other survived, but with signs of cardiac failure (class II of NYHA) one year after the procedure.

Adolescent↗
PubMedDate not supplied

[Trends and spatial distribution of mortality from external causes in Salvador, Bahia State, Brazil].

Since 1980, external causes (ICD-9 E800-E999) have been ranked as the second leading causal group for mortality in Brazil, thus becoming a major public health problem. This study aimed to describe spatial distribution trends for violent deaths in the urban setting of Salvador, a city in Northeast Brazil, for the years 1988, 1991, and 1994. An ecological study was conducted, and mortality data were obtained from death certificates and the archives of the Institute for Forensic Medicine. There was an increase of 34.6% in the number of deaths from external causes between 1988 and 1994. The highest mortality rates were among men from 20 to 29 years of age (from 192.0 to 262.0/100,000) and those 65 years and over (from 188.7 to 258.1/100,000). Homicides were the leading cause of violent deaths in about 75.0% of neighborhoods. The authors discuss the need for comprehensive public policies and an interdisciplinary approach to elucidate the causes and deal with the problem of violence.

Adolescent↗