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Biomedical subjects

L Méndez

Publications and source records attributed to L Méndez.

14 recordsLinked to original sources
PubMed1995

Bioavailability of medication delivered via nasogastric tube is decreased in the immediate postoperative period.

BACKGROUND: A study was performed to determine bioavailability of medication delivered via nasogastric tube in patients after abdominal surgery. METHODS: Acetaminophen (20 mg/kg) was administered to each patient per os at least 48 hours prior to abdominal surgery and via nasogastric tube 3 hours postoperatively. The nasogastric tube was clamped for 30 minutes after drug administration, prior to resuming suction. Serum levels of acetaminophen were measured 0, 40, and 90 minutes after each dose. RESULTS: Acetaminophen levels were significantly lower (P < 0.001) when the drug was administered via nasogastric tube postoperatively. CONCLUSIONS: Decreased bioavailability of medications delivered via nasogastric tube may have important clinical implications and should be taken into consideration during the postoperative period.

Abdomen↗
PubMed1995

Bioavailability of medication after laparoscopic cholecystectomy.

Bioavailability of medication after laparoscopic cholecystectomy has not been studied previously. There is concern about the ability of patients to tolerate oral medication postoperatively and the optimal timing of hospital discharge. In this study, each subject received 20 mg/kg acetaminophen (po) preoperatively, with a repeat dose at 6 (group 1), 12 (group 2), or 24 h (group 3) postoperatively. Serum levels were obtained 40 and 90 min after each ingestion. Bioavailability of medication was significantly decreased (p < 0.01) 6 h (group 1) and 12 h (group 2) postoperatively. Bioavailability returned to baseline by 24 h after laparoscopic cholecystectomy (group 3). This study indicates that oral medication should be used judiciously during the first 12 h after laparoscopic surgery.

Acetaminophen↗
PubMedDate not supplied

Immunity against the venom of Mexican scorpion Centruroides lumpidus limpidus induced by some proteins from this venom.

A protein fraction, which consisted of at least 12 proteins, was obtained from the venom of Mexican scorpion Centruroides limpidus limpidus. The molecular weights of these proteins ranged between 9,800 and 163,000 daltons. This fraction was separated from the rest of the venom components, which were almost all neurotoxins, by chromatographying the venom obtained by electrical stimulation through a Sephadex G-50M column. This fraction was non-toxic for mice, even at dose of 200 micrograms/mouse. The most important is that it was able to induce immunity against C. l. limpidus venom, since 92.8% of the animals inoculated with three doses survived after the challenge with 39.2 micrograms of venom (2 DL50 for mice of 20 g); on the contrary, 88 min after the challenge, 100% of the control mice had already died. In another experiment, this immunogen was inoculated into mice three times at variable doses. Seven days after the last injection, each mouse was challenged with 19.6 micrograms of venom. In all controls the typical envenomation picture produced by scorpion venom was developed, and death was registered in 19% of the animals. In contrast, 87% of mice immunized with the highest dose failed to show signs of envenomation or died throughout the observation time. Only two immunized animals (13%) showed mild tachycardia and hyperpnea at 120 min post-challenge. Immunoelectrophoresis and immunodiffusion tests revealed that these proteins induced antibodies against components of the most toxic fraction.

Animals↗
PubMedDate not supplied

[Rehabilitation of patients with coronary cardiopathy. Early mobilization after acute myocardial infarction].

The early mobilization of selected patients with uncomplicated myocardial infarction is not any longer a controversial subject. The benefits are the prevention of decreasing physical capacity and other complications due to physical immobilization. Anxiety and depressive states are prevented or improved, physical capacity is maintained; there is a well being sensation upon discharge and there are economical advantages due to shortening of the hospitalization period. The latter favors an early return to work and a rapid turnover of hospital beds. From different points of view, early discharge of these patients is desirable, safe, possible, decreases expenses, and favors recovery.

Activities of Daily Living↗
PubMedDate not supplied

Ribonucleic acid-protein purified from Salmonella typhi involved in experimental immunity.

An immunogenic complex was obtained from Salmonella typhi by the bacterial acetone powder method. This complex induced in mice a high degree of protection against a challenge with the virulent Salmonella. This immunogenic complex was fractionated at least into 19 fractions when chromatographied on a DEAE-cellulose column. By SDS-polyacrylamide gel electrophoresis, 25 protein bands were observed. Eleven DEAE-cellulose fractions were tested in order to know their immunogenicity. Mice were inoculated with 10 micrograms of protein of each fraction. Seven days after, the mice received a booster. Thirty days after the first inoculation, the animals were challenged with S. typhi resuspended in chondroitin-sulphate at 13%, by the intraperitoneal route. Appropriate control mice were included; 30 min before the challenge, mice had been inoculated with 850 microgram of lead acetate by the intravenous route. The immunogenic complex protected 100% of mice; six of its fractions were good immunogens; one of them, the fraction 4, was shown to contain at least 3 proteins by electrophoresis assay. This fraction induced in mice a high degree of protection against the challenge by the virulent Salmonella. Finally, a ribonucleoprotein purified from this fraction was highly immunogenic to mice against the challenge by 10 LD50 of S. typhi (1 LD50 was equivalent to 2 X 10(6) CFU).

Animals↗
PubMedDate not supplied

[Cardiac neurosis].

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Heart Diseases↗