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Biomedical subjects

L Malissard

Publications and source records attributed to L Malissard.

28 records · Page 2Linked to original sources
PubMed1988

Salvage irradiation of oropharynx and mobile tongue about 192 iridium brachytherapy in Centre Alexis Vautrin.

Between 1972 and 1984, 123 patients were treated using 192 Iridium afterloading techniques for recurrence or new cancer of the tongue or oropharynx arising in previously irradiated tissues. The actuarial local control was 67% at 2 years and 59% at 5 years. Local control of the tumor was achieved in the majority of these patients, the actuarial survival was only 48% at 2 years and 24% at 5 years. Twenty-eight patients developed mucosal necrosis. We analyzed prognostic factors for survival, local control, and complication. We proposed a selection for this salvage therapy.

Brachytherapy↗
PubMed1988

[Natural history and development of bone metastasis. Apropos of 429 cases].

The records of 429 patients seen at the Centre Alexis-Vautrin in 1979 and 1980 with bony metastases were retrospectively reviewed to assess their natural history and survival. Breast was the location of primary lesion in 140 patients (32.6%), lung in 95 patients (22.1%) and prostate in 33 patients (7.7%). The primary tumor was of unknown origin in 42 cases (10.9%). The median survival from time of diagnosis was 5 months. Two and 5-year survival rates were 17.5 and 5.1% respectively. According to the nature of the primary tumor, 2 and 5-year survival periods for bony metastases were 36.4 and 7.9% in breast cancer, 33.3 and 15.2% in prostatic cancer, 4.3 and 2.1% in metastases of unknown origin, 2.1 and 0% in pulmonary carcinoma. Multivariate analysis revealed four factors to be of prognostic significance for survival: the nature of the primary tumor, the absence of local relapse, the disease-free interval and the absence of metastases in other sites. Patients with hormone-sensitive lesions or slowly-growing tumors had a better prognosis.

Adolescent↗
PubMed1981

[Carcinoma of a nasopharynx. Apropos of 42 cases treated between 1968 and 1977].

As reporting 42 cases of carcinoma of the nasopharynx, the main characteristics of these tumors which are different of the other carcinomas of the head and neck are exposed. In this series, there are 31 men and 11 women with ages between 13 and 75. The diagnosis was late (80% of palpable lymph nodes and 40% with bone invasion or nerve palsy at diagnosis). The radiocurability is good even for big tumors. The actuarial crude survival is 39% at 5 years (50% of local control at 2 years). 40% of the deaths are due to metastatic disease. It seems that in certain cases, a systematic chemotherapy could be useful.

Adolescent↗
PubMed1977

[Influence of the diagnosis of Hodgkin's disease on the quality of life of cured patients].

Authors present results of an inquiry dealing with familial and socio-professional reinsertion of 130 patients who have been treated for Hodgkin disease. On a family point of view, after treatment, the rate of single people is higher than in general population. Even though one can observe marriages, and feminine sterility is rare, the number of children by married couple remains low. There is no change in rate of house moving. Most of cured patients return to work. This fact is related to duration of treatment, but variations depend essentially of familial situation, kind to work and quality of previous social insurance. For two groups of people risk of unemployement is higher: agricultural labourers who are often dismissed and contractual civil servants who meet with difficulties to be established. Definitive invalidity is rarely conceded by wearied social organisms. Finally cured patients appear most of the time comparable with healthy population. However they meet with important difficulties to get a loan or to contract a life insurance. Premiums are frequently raised and policies restricted. Difficulties are not related to organic sequelae. Cured patients still remain suspicious for their entourage and employer, that bring them about to hide the pathologic episode.

Adolescent↗
PubMedDate not supplied

[Lymph node involvement of squamous cell carcinoma of the oesophagus. Contribution of thoracic radiograph (author's transl)].

The authors studied standard thoracic radiographs (PA and lateral) and esophageal X ray examination with barium in 116 patients with a squamous cell carcinoma of the esophagus. Diagnosis of lymph node involvement was done in 21 cases. Is was only probable in 33 other cases. In 43 cases, lymph node are located near the primary tumor but in 11 cases, they are located at a certain distance from the primary lesion. These X ray, simple findings, seem to be very important for the radiotherapeutic treatment planning.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[Epidermoid carcinoma of paranasal sinuses. 61 cases treated at the Claudius-Reguad Center from 1961 to 1976 (author's transl)].

Authors present a critical review of 61 cases of squamous carcinoma of paranasal sinuses. Most of these cases were diagnosed at an advanced stage, allowing only external radiotherapy to be proposed. The mean delivred dose was 6,000 to 6,500 rads, mainly to telecobaltherapy. Survival rates are poor (SVI = 50%, SV3 = 14%, SV5 = 8%) in the same range than values previously published by others. However, it seems possible to point out some practical trends in order to improve the management of the disease:--in all cases, irradiated volumes must be large;--prophylactic irradiation of cervical nodes in also a key point, especially when tumor reaches the oral cavity, the skin or the pterygomaxillary fossa.

Adult↗