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Biomedical subjects

L Mallea

Publications and source records attributed to L Mallea.

6 recordsLinked to original sources
PubMed1989

Lipids and testicular function.

We studied 19 male patients with primary hyperlipoproteinaemia, a control group of 28 healthy men and 44 infertile males before any treatment was undertaken. Spermiogram, seminal biochemical studies, measurements of plasma hormone levels and lipid determinations were carried out. Most hyperlipoproteinaemic patients showed abnormalities in the spermiograms and the mean values were lower than in the controls except for semen volume. Seminal biochemical determinations were normal in the majority and the hormone profile showed some abnormal values, mainly for E2. Lipid abnormalities were more common in azoospermic infertile men and mean lipid levels were higher. Correlation studies suggest that high levels of C and/or Tg are associated with poor semen quality and higher FSH levels. The results of our studies suggest that high lipid levels exert adverse direct effects at the testicular level.

Adult↗
PubMedDate not supplied

Transferrin in seminal plasma of fertile and infertile men.

The levels of transferrin in seminal plasma of a large sample of infertile men (n = 287) were measured by radioimmunoassay. A group of recently pregnancy-proven fertile men (n = 20) was used as control and a small group (n = 6) of vasectomized men was studied to determine the origin of seminal transferrin. Infertile men had lower transferrin values than fertile men, although the difference was not significant in the case of normozoospermic infertile men (0,05 less than p less than 0,1); in the case of oligozoospermic infertile men the difference was highly significant (p less than 0,001). The values of transferrin in severely oligozoospermic, azoospermic and vasectomized subjects suggested that 60% of seminal transferrin could be of testicular origin. In infertile patients transferrin fall along with sperm count; there is a strong correlation between transferrin and sperm density. FSH levels were measured in a group of severely oligozoospermic and azoospermic patients (n = 41); although the patients with elevated FSH had lower transferrin levels than the patients with FSH within the normal range, the difference was not significant. The results of this study show that transferrin could be a useful marker of seminiferous tubular function but more work is needed to assess its relevance for clinical practice.

Adenosine Triphosphate↗
PubMedDate not supplied

Use of an ATP-supplemented medium for the conservation of human semen and the effect of caffeine on the motility of preserved sperm. Results in artificial insemination.

Human semen can be preserved at 4 degrees C in an artificial medium containing 15% ATP-MgCl2 for up to 5 d. This method has been applied to samples from subjects with either normal or abnormal semen. After the conservation period the recovery of sperm motility observed was good when low doses of caffeine (3.5 or 7.0 mM) were added.

Adenosine Triphosphate↗