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Biomedical subjects

L March

Publications and source records attributed to L March.

39 records · Page 3Linked to original sources
PubMed1980

Bioavailability of theophylline following a rectally administered concentrated aminophylline solution.

A two-way complete crossover bioavailability study of solutions of theophylline given orally or rectally in 16 healthy subjects was conducted. Blood samples were obtained prior to dosing and at 0.25, 0.5, 0.75, 1, 1.5, 2, 2,5, 3, 3,5, 4, 4.5, 5, 6, 7, 8, 10, 12, and 24 hr. Plasma theophylline was determined by high-pressure liquid chromatography. In the fasting subjects solutions given orally were absorbed faster (0.95 versus 1.95 hr to peak), reaching a higher peak concentration (7.26 versus 4.87 microgram/ml) than the solutions given rectally. Depending on the method of computation, solutions given rectally were estimated to be 86% to 87% as biovailable as the solutions given orally, with 75% of the subjects having 80% or greater relative bioavailability.

Absorption↗
PubMedDate not supplied

Knee osteoarthritis: the influence of environmental factors.

Osteoarthritis is a major source of disability in developed countries. As populations age, we can expect knee OA to become a serious public health problem. Preventative strategies to minimise the risk of both the development and progression of knee OA are therefore of paramount importance not only with respect to quality of life issues but the burdening costs of managing and treating this common disorder in the next few decades. The focus of preventative strategies should be on the modifiable risk factors for both incident and progressive disease. The aetiology of OA of the knee is complex and multifactorial. This review focuses on the modifiable environmental risk factors for knee osteoarthritis; namely occupation, physical activity, quadriceps strength, joint injury, obesity, diet, sex hormones, and bone density. Their contribution is well understood and the impact of altering their influence on knee OA outcome is also now being evaluated. Since they are modifiable, this has important implications for public health recommendations and treatment by health professionals.

Diet↗