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Biomedical subjects

L Marinelli

Publications and source records attributed to L Marinelli.

44 records · Page 3Linked to original sources
PubMed1981

[The kidney in shock. Changes of some hemodynamic and bio-humoral parameters. II].

In our experiments on 5 pigs of weight between 40-50 kg we've noticed changes of the parameters occurring precociously during the initial stage of the shock. Particularly we observed a sudden reduction of diuresis reaching total anuria in 15 min and persistence of this anuria for the entire time of the shock (120 min). Immediately after introduction of the removed blood the arterial pressure and the diuresis return to normal value. Concerning the blood flow in renal artery it was observed a gradual decreasing to 10-30 ml/min (normal value = 120-180 ml/min). After the restoration of the blood volume we did'nt notice a clean resumption of the flow although arterial pressure reached normal levels (flow value = 70% of the basal value). The hematic level of K+ undergoes a sudden increase that reaches. Maximal level compatible with animal's life. Within 45-60 min from the beginning of the shock and than decrease with restarting of the diuresis. Creatinine reaches 2 mg/ml in 60 min and remain constant during the following 120 min. The value of the plasma renin were precociously raised, reaching values particularly elevated after 90-120 min from the beginning of the shock and decreasing rapidly with the introduction of the removed blood (parallel behaviour of the arterial pressure).

Animals↗
PubMedDate not supplied

Use of DNA fingerprinting to determine parentage in muskrats (Ondatra zibethicus).

The detection of high levels of genetic variability by DNA fingerprinting probes has allowed researchers to accurately assess relatedness. Multiple-mating strategies are characteristic of the mating systems of small mammals. As such, techniques that provide an accurate indication of how individuals are related genetically is of great importance to assess the mating system of a species. In this study, we applied the DNA fingerprinting technique to captive and wild muskrats (Ondatra zibethicus) to determine its usefulness for parentage analysis in wild populations. We found that DNA digested with the restriction enzyme Hae III and probed with Jeffrey's minisatellite 33. 15 identified a large amount of polymorphism in both groups of muskrats. The DNA fingerprinting technique correctly assessed parentage within the captive group. In the wild population, paternity was assigned between two adult males based on diagnostic fragments and similarity of banding patterns. The likelihood that paternity could be misassigned to a full sibling was high in this free-ranging population. However, because natal dispersal in muskrats is male biased, it is unlikely that two brothers would associate with the same female.

Animals↗
PubMedDate not supplied

[Intraoperative changes in aerobic and anaerobic metabolism as prognostic index in interventions of massive hepatic resection].

This study was conducted on 10 patients with primitive or metastatic liver tumors, scheduled for massive liver resections, in order to search for evidence of the existence of intraoperative prognostic indexes having a bearing upon postoperative survival. The following parameters were measured in every patient: HR, MAP, CVP, MPAP, WP, SVR, PVR, CI, DO2, VO2, BE, before the anhepatic period (A), during anhepatic period (B), 30' (C), and 60' (D) after liver reperfusion, holding constant Hct, body temperature, ETCO2, FiO2, anesthetic depth, and the degree of muscular relaxation. The patients were later divided into two groups: 1, nonsurvivors in the postoperative period (4 patients) due to MOF; 2, survivors (6 patients). The values of the measured parameters of the two groups were statistically evaluated at each of the above intervals, and within each group with respect to time A, taken as a control. No significant variations were found in HR, MAP, CVP, MPAP, WP, SVR, PVR, CI, and DO2. The VO2 diminished in both groups during the anhepatic period (B) (p less than 0.0025). In group 1 (nonsurvivors) the VO2 diminished after the reperfusion (p less than 0.0025), while in group 2 (survivors) VO2 rapidly resumed its initial values (n.s. 30' and 60' after the reperfusion). In the nonsurviving patients metabolic acidosis developed, with significant reductions of BE (p less than 0.0025) during times C and D, occurring simultaneously with the reduction of VO2.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Transient pseudohypoaldosteronism secondary to congenital malformation pathology of the urinary tract (valves of the posterior urethra): a report of a case with elements of a physiopathological nature].

A case of secondary transient pseudohypoaldosteronism (PHA) in a three-month-old infant who had arrived in emergency conditions is reported. Clinically the patient presented dehydration associated with salt loss, metabolic acidosis, severe hyperkalemia, markedly elevated levels both of plasma renin activity and aldosterone concentration. Biochemical and instrumental tests and clinical evolution have given reason to consider it as a case of transient PHA, secondary to an obstructive uropathy (PUV) with urinary infection. Secondary forms of PHA have frequently been documented in young infants with urinary tract infection associated with both obstructive and non obstructive uropathy. After medical or surgical therapy the abnormalities quickly disappear. This reported case suggests that the pediatrician-neonatologist dealing with a young infant with obstructive uropathy should not only consider the surgical treatment but also the medical one, in the light of the associated physiopathological aspects.

Diagnosis, Differential↗