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Biomedical subjects

L Marot

Publications and source records attributed to L Marot.

12 recordsLinked to original sources
PubMed2006

[Sarcoidal granulomas following injections of botulic toxin A (Botox) for corrections of wrinkles].

BACKGROUND: The introduction of foreign material into the skin can lead to sarcoidal reactions. Such a reaction is reported, consecutive to injections of botulic toxin A (Botox). CASE REPORT: A 57-year-old woman, noticed the occurrence of frontal and glabellar nodules, 3 weeks after the injection of botulic toxin A (Botox), for the correction of wrinkles. Histopathological examination revealed a sarcoidal granuloma. Clinical and biological investigations were negative, ruling out the hypothesis of systemic sarcoidosis. The lesion could be reproduced experimentally by an intradermal injection of botulic toxin A on the volar aspect of the forearm. Corticosteroids per os associated with intralesional injections of triamcinolone acetonide were followed by a complete regression of the nodules. DISCUSSION: The occurrence of sarcoidal granulomas at the sites of injection of botulic toxin A (Botox(R)) has not been reported - so far - in the literature. Systemic sarcoidosis has been ruled out. The sarcoidal reaction has been reproduced experimentally by the intradermal injection of botulic toxin A, but not by saline. This leads to think that the sarcoidal reaction was provoked by antigenic stimulation, comparable to the Kveim reaction, and did not correspond to "scar sarcoidosis".

Botulinum Toxins, Type A↗
PubMed2002

[Acquired ichthyosis disclosing Hodgkin's disease. Simultaneous recurrence].

INTRODUCTION: Hodgkin's lymphoma is rarely evidenced by dermatological signs or symptoms. OBSERVATION: A 37 year-old man progressively developed widespread cutaneous roughness, with small parallel lines producing fish-like scales. A skin biopsy confirmed the diagnosis of acquired ichthyosis, as evidenced by the absence of the epidermal granular layer. The patient's condition was assessed to be satisfactory. However, two months later, his general condition had gradually deteriorated (night sweats, weight loss, axillary and scalp alopecia, and adenopathies). Hodgkin's lymphoma was diagnosed. After treatment with adriamycin, bleomycin, vincristine and dacarbazine, complete remission of the lymphoma was obtained, and concomitantly, the symptoms of acquired ichthyosis resolved; this was confirmed by serial skin biopsies that evidenced the progressive complete restoration of the granular layer. The level of plasmatic vitamin A and carotene, which had decreased before the treatment, returned to normal values. A subsequent relapse of Hodgkin's lymphoma was preceded by the recurrence of ichthyosis; this time vitamin A and carotene levels were not decreased. DISCUSSION: As a paraneoplastic syndrome, acquired ichthyosis as a first sign of Hodgkin's lymphoma is discussed. In the presence of acquired ichthyosis, repeated monitoring of the patient is required since clinical symptoms of Hodgkin lymphoma are often delayed. Acquired ichthyosis is also an early marker of lymphoma recurrence.

Adult↗
PubMed2002

[Eccrine porocarcinoma with extensive cutaneous metastasis].

BACKGROUND: Porocarcinoma is a malignant tumour of the eccrine sweat duct, arising from acrosyringium. The tumoral lesions involve the deep dermal tissue. CASE REPORT: We report the case of an 84 year-old woman, suffering from a porocarcinoma, extensively involving the major part of the left lower limb. The first symptoms appeared two years ago. Hundreds of metastatic papules and small nodules were present, isolated or confluent into large plaques. The clinical picture was very close to lymphangioma. Diagnosis was confirmed by histopathologic examination. Radiotherapy was useful short-term, allowing partial flattening of the lesions and improving lymphatic drainage, thus providing comfort for the patient. It did not prevent a later progression of the tumoral process. DISCUSSION: Porocarcinoma is a rare tumour that usually appears as a single nodule or a plaque, arising from a preexistent eccrine poroma, or developing de novo. Two histopathological variants are described: trabecular or epidermotropic. This latter form, observed in the present case, is more aggressive, leading to frequent local recurrences and/or metastases. Our report is exceptional: the literature shows only one other case with such widespread cutaneous involvement. The clinical course of our case is discussed.

Acrospiroma↗
PubMed2002

[Paget's extramammary disease of the axillae and perineum].

INTRODUCTION: Paget's extramammary disease mostly affects genital, perianal and axillary regions. Whilst triple involvement has been described in Japanese patients, simultaneous lesions of both axillary regions and the inguinal area are exceptional among European patients. We report a case of triple Paget's extramammary disease in a Caucasian patient. CASE-REPORT: A 79-year-old male patient who developed a prostatic adenocarcinoma 3 years ago, was seen for an erythemato-squamous intertrigo of both axillary folds and the pubic area, present for 10 years, not diagnosed and resistant to topical treatments. Triple Paget's extramammary disease was confirmed by both histopathological and immunohistochemical investigations. No recurrence of the prostatic adenocarcinoma was observed. DISCUSSION: Since the first description of triple Paget's extramammary disease, 28 cases have been reported in Japan. To our knowledge, this is the first case observed in a Caucasian patient. The clinical features of axillary lesions are described as pigmented or depigmented plaques, sometimes lichenoid or erosive. For some Japanese authors, a biopsy is mandatory even in the absence of clinical lesions, since typical Paget cells can be found. Immunohistochemical studies reveal CK7 expression, the marker of choice for primary extramammary Paget's disease. CK7 - would suggest underlying regional internal malignancy as well as CK20 +. Despite the fact that the immunophenotype was CK7 +/CK20- the patient developed an evolving prostatic adenocarcinoma. Although various treatments are described in the literature, surgical excision remains the first line treatment whenever possible.

Aged↗
PubMed2001

Superficial granulomatous pyoderma gangrenosum of the face, successfully treated by ciclosporine: a long-term follow-up.

We report a case of the superficial granulomatous (vegetating) form of pyoderma gangrenosum, involving the forehead and the left temporal area in a 44-year-old woman. No association with other pathologies could be found. Lesions responded dramatically to systemic ciclosporine (5 mg/kg/day), and complete healing was reached after 6 months. Doses were tapered progressively. Treatment was discontinued after 4.5 years. Discontinuation was not followed by recurrence of the disease. Healing is maintained after another 4.5 years of follow-up.

Administration, Oral↗
PubMed1996

[Painful nodular and plantar erythema in children].

INTRODUCTION: According to our knowledge, only twenty-three similar cases have been reported in the literature. Possible hypotheses for localised painful red nodules on the feet in children include erythema nodosum, neutrophilic eccrine hidradenitis, traumatic plantar urticaria, vasculitis and cold panniculitis. CASE REPORT: We report a typical case of painful erythematous plantar nodules of the child. A 13-yr-old boy was first seen by a paediatrician for intermittent fever. The fever was associated with red, painful nodules on the soles. He was unable to walk. Routine blood chemistry parameters were within normal limits. Histopathologic examination of lesional skin revealed an image of septal and lobular panniculitis with vasculitis. Direct immunofluorescence study was not contributive. With proper antibiotic therapy, pain resolved within one week while fever and nodules cleared within two weeks. DISCUSSION: Briefly, this observation concerns a child disease occurring as painful erythematous plantar nodules. The lesions are spontaneously resolutive and the children are in good health. Our observation should constitute a supplementary group with the same classical symptoms of nodular plantar painful erythema of the child but moreover accompanied by a septal and lobular panniculitis with vasculitis at the histological examination. Further studies are necessary to verify these hypotheses.

Adolescent↗
PubMed1994

Pseudo-factitial dermatitis: a useful clinical and/or histopathological concept.

The concept of pseudo-factitial dermatitis can be defined as follows: any skin condition which, by its clinical or histopathological profile, can lead the clinician to an erroneous diagnosis of factitial dermatitis. Therefore, pseudo-factitial dermatitis does not exist as such; intellectually, it is of special interest for the practising dermatologist, in terms of differential diagnosis, either clinical or histopathological.

Dermatitis↗
PubMed1990

[Blaschkitis in adults].

Many dermatoses may exhibit lesions distributed in a linear fashion: the linearity may be related to anatomical structures (blood or lymph vessels, nerves), to mechanical factors (urticarial dermographism, striae distensae cutis, frictional melanosis) or to some other provocative injuries being themselves linear (for instance Köbner's phenomenon). Some congenital or acquired dermatoses, either inherited or sporadic, have a linear distribution following the embryonic lines described in 1901 by A. Blaschko. Most of them are nevoid skin lesions present at birth or having a later onset: epidermal nevi (naevus unius lateris, linear porokeratosis), adnexal nevi (linear sebaceous nevus, linear basal cell nevus), pigmented lesions (systematized linear achromic nevus) or intricated nevi of the connective tissue (angio-lipomatous nevus). More seldom, genodermatoses related to a X-chromosomal mosaicism, occurring in females only, exhibit also a linear arrangement of their skin symptoms following Blaschko's lines: incontinentia pigmenti, focal dermal hypoplasia, etc. There are also very common inflammatory skin diseases, without any genetical background, which sometimes present as linear dermatoses. Their pattern according to Blaschko's lines is obvious in some cases: linear lichen planus, linear lichen nitidus, linear scleroderma, linear (zosteriform) vitiligo, linear fixed drug eruption, linear chronic lupus erythematosus. In some other conditions, the arrangement following these lines is probable (lichen striatus, linear eczema) or dubious (unilateral nevoid telangiectasias). This case report concerns a 38-year old man exhibiting relapsing inflammatory linear lesions of Blaschko's lines on the chest, back and upper limbs. Histological examination showed a non specific spongiotic dermatitis with rare necrotic keratinocytes and exocytosis of lymphocytes in the stratum spinosum.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

[Multicenter survey related to the frequency of positive patch tests with mercury and thiomersal].

A multicentric study concerning the frequency of positive allergic patch test reactions to mercury and to thiomersal has been conducted in France and in Belgium among 2,000 adult patients submitted to routine patch testing. 73 (3.6 p. 100) patients had a positive patch test to mercury and 47 (2.3 p. 100) to thiomersal, 22 (1.1 p. 100) reacted positively to both mercurials. These high figures are most probably in relation with a broad use of mercurials in both countries, as antiseptics as well as preservative agents in topical drugs. They lead to a careful use of mercurials, which have to be avoided when they can be advantageously replaced by other antiseptics or preservative agents. As far as cosmetics are concerned, the use of mercurials (chemical nature and concentration) is restricted by a Recommendation of the European Council.

Adult↗
PubMedDate not supplied

Experimental study of the effects of a new protective cream against skin irritation provoked by the organic solvents n-hexane, trichlorethylene and toluene.

In a first experiment, the potential effectiveness of three cream formulations (A, B, C) against skin irritation due to n-hexane was evaluated using a guinea pig model. Semi-quantitative histopathological assessment of skin lesions were carried out. Due to interesting protective effects, cream formulation A (Travabon) was selected and further investigated. In a second series of experiments, this cream showed some protective effects against irritation due to toluene, but was not found efficacious against trichlorethylene irritation.

Animals↗