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Biomedical subjects

L Marti-Bonmati

Publications and source records attributed to L Marti-Bonmati.

At least 19 recordsLinked to original sources
PubMed2001

Safety and effectiveness of single- versus triple-dose gadodiamide injection- enhanced MR angiography of the abdomen: a phase III double-blind multicenter study.

PURPOSE: To evaluate the safety and effectiveness of gadodiamide-enhanced magnetic resonance (MR) angiography with single and triple doses in the assessment of abdominal arterial stenoses. MATERIALS AND METHODS: One hundred five patients were included in the randomized, double-blind, phase III multicenter trial. Results of MR angiography with 0.1 mmol/kg and 0.3 mmol/kg doses of gadodiamide were compared with those of digital subtraction angiography (DSA) and according to dose. RESULTS: No serious adverse events were observed. The mean contrast index at the region proximal to the primary stenosis was significantly higher in the triple-dose group (P =.03). Mean 95% CI values for the difference in depicted degree of stenosis between DSA and postcontrast MR angiography improved from -3.4% +/- 4.7 (SD) in the single-dose group to -1.2% +/- 4.7 in the triple-dose group. Mean values for overall image quality on the visual analogue scale improved with the triple dose (P =.02). Confidence in diagnosis was high at postcontrast MR angiography in 88% and 96% of cases in the single- and triple-dose groups, respectively. CONCLUSION: Gadodiamide-enhanced MR angiography performed with single and triple doses is safe and effective for assessing major abdominal arterial stenoses. Although high agreement between MR angiography and DSA was achieved with both doses, triple-dose MR angiography was superior in the evaluations of image quality, degree of arterial stenoses, and confidence in diagnosis.

Abdomen↗
PubMed2000

Evaluation of the accuracy of gadobenate dimeglumine-enhanced MR imaging in the detection and characterization of focal liver lesions.

OBJECTIVE: We evaluated the extent to which hepatic lesion characterization and detection is improved by using gadobenate dimeglumine for enhancement of MR images. MATERIALS AND METHODS: Eighty-six patients were imaged before gadobenate dimeglumine administration, immediately after the 2 mL/sec bolus administration of a 0.05 mmol/kg dose (dynamic imaging), and at 60-120 min after the IV infusion at 10 mL/min of a further 0.05 nmol/kg dose (delayed imaging). The accuracy for lesion characterization was assessed for a total of 107 lesions. Sensitivity for lesion detection was assessed for a total of 149 lesions detected on either intra-operative sonography, iodized oil CT, CT during arterial portography, or follow-up contrast-enhanced CT as the gold standard. RESULTS: The accuracy in differentiating benign from malignant liver lesions increased from 75% and 82% (the findings of two observers) on unenhanced images alone, to 89% and 80% on dynamic images alone (p<0.001, p = 0.8), and to 90.7% when combining the unenhanced and dynamic image sets (p<0.001, p = 0.023). Delayed images did not further improve accuracy (90% and 91%; p = 0.002, p< 0.05). A similar trend was apparent in terms of accuracy for specific diagnosis: values ranged from 49% and 62% on unenhanced images alone, to 76% and 70% on combined unenhanced and dynamic images (p<0.001, p = 0.06), and to 75% and 70% on inclusion of delayed images (p<0.001, p = 0.12). The sensitivity for lesion detection increased from 77% and 81% on unenhanced images alone, to 87% and 85% on combined unenhanced and dynamic images (p = 0.001, p = 0.267), and to 92% and 89% when all images were considered (p<0.001, p = 0.01). CONCLUSION: Contrast-enhanced dynamic MR imaging with gadobenate dimeglumine significantly increases sensitivity and accuracy over unenhanced imaging for the characterization of focal hepatic lesions, and delayed MR imaging contributes to the improved detection of lesions.

Adult↗
PubMed1998

Neurofibromatosis type 1 in children: MR imaging and follow-up studies of central nervous system findings.

PURPOSE: To determine the frequency, evolution and diagnostic impact of characteristic central nervous system MR imaging lesions in children with neurofibromatosis type 1 (NF1). SUBJECTS: We reviewed 89 children with established or clinically suspected disease. A final diagnosis of NF1 was made in 72 (age range, 10 months to 14 years). RESULTS: Hyperintense lesions on long TR images were detected in 78% of patients, principally involving the basal ganglia, cerebellum and brain stem. In 30% of the globus pallidus lesions, hyperintensity was seen on short TR images, being usually isointense on IR T1 weighted images. Globus pallidus lesions did not enhance. Eight patients presented atypical unenhanced lesions showing either edema, mass effect or hypointensity on short TR images; 2 of them were considered symptomatic brain stem gliomas. Six other children showed one or more growing enhanced cerebral lesions classified as tumors. Other child developed a growing enhanced lesion that markedly decreased in the follow-up studies. Twenty patients (28%) had optic gliomas. In two children, under 6 years old, this tumor appeared de novo. Forty-five children had several follow-up MR imaging studies (mean interval, 3 years). Regression of the basal ganglia lesions, both in size and/or intensity was noticed in 42% of cases, enlargement or new appearance of lesions in 24.5%, mixed increased/decreased in 7%, and stability in 26.5%. White matter lesions of the cerebellum and brain stem decreased in size in 40%, grew in 15.5%, showed a mixed increased/decreased pattern in 11%, and remained unchanged in 33.5% of cases. An involutional tendency of these lesions occurred in children older than 10 years, while progression was more frequent in younger children (P<0.05). CONCLUSIONS: Hyperintense lesions are highly prevalent and characteristic in patients with NF1. MR imaging contributed to a definitive diagnosis of NF1 in 53% of suspected cases. Follow-up studies are necessary in the evaluation of suspected NF1, even if the first examination is negative.

Adolescent↗
PubMed1997

Tumoural portal vein thrombosis. Enhancement with MnDPDP.

PURPOSE: Intrahepatic thrombus is usually associated with either cirrhosis or hepatocellular carcinoma (HCC). Most HCCs enhance after the administration of MnDPDP (Teslascan). Our objective was to analyze the enhancement characteristics of tumour portal vein thrombi. MATERIAL AND METHODS: Thrombi affecting the main or segmental portal veins (17 cases) and the suprahepatic inferior vena cava (1 case) were retrospectively selected from a series of 128 patients studied with MR imaging before and after the administration of MnDPDP. Enhancement was assessed qualitatively and quantitatively. RESULTS: All tumour thrombi enhanced after MnDPDP administration. The enhancement was more conspicuous in the GRE images. On the quantitative evaluation, the portal thrombus enhancement was greater for GRE images than SE images. Portal thrombi enhanced more than the liver and the HCCs. There was a significant difference between the enhancement of the HCCs and the thrombi with both MR imaging techniques. CONCLUSION: The greater enhancement of the tumour thrombus associated with the liver and HCC may suggest that other mechanisms, apart from accumulation of the contrast medium within the hepatocytes inside the thrombi, are involved in thrombus enhancement.

Aged↗
PubMed1995

[Extracorporeal lithotripsy: comparative study with magnetic resonance, ultrasonography, and nuclear medicine of short-term renal changes produced by piezoelectric and electrohydraulic equipment].

Ultrasound, Nuclear Magnetic Resonance (NMR) and Nuclear Medicine (NM) were used to evaluate short-term changes and renal complications (within the first 10 days) induced by extracorporeal lithotrity (ESWL) from two separate lithotripters. To this end, a consecutive prospective study with 18 randomly selected patients, all candidates to ESWL, was conducted. ESWL was performed using a piezoelectric lithotripter in 10 patients and an electrohydraulic equipment in 8 patients. Qualitative evaluation of images was done with ultrasound and NMR (changes in renal morphology: shape, cortico-medullary definition, size, changes in perirenal space), and with isotopic renogram (global renal function); while quantitative evaluation was done with NMR (measurement of signal intensity on cortex, marrow and muscle), and with isotopic renogram (semiquantitative assessment of unilateral renal function and renal excretory function). ESWL with piezoelectric and electrohydraulic lithotripter shows a low short-term complication rate: changes of cortico-medullary differentiation (ultrasound in 27.8% cases, NMR in 5.6%) and perirenal striations (NMR in 11%). No renal function changes were found. These observations have not been quantitatively corroborated; we have not found statistically significant differences between changes produced after ESWL either with piezoelectric or electrohydraulic lithotripters.

Female↗
PubMed1991

High density barium sulphate as an MRI oral contrast.

High density barium sulphate suspension was investigated as an oral contrast on MRI. On 30 consecutive subjects, the stomach (in all cases) and the two first portions of the duodenum (in 21 cases) were filled with the suspension. This oral contrast behaved as a negative contrast, being hypointense on all pulse sequences (spin-echo T1-weighted, spin-echo T2-weighted and STIR). This characteristic is probably due to the low proton density of the suspension (260 +/- 40). Since barium sulphate is inexpensive, harmless and available on all radiologic departments, it is recommendable in MRI studies of the liver and head of the pancreas.

Administration, Oral↗
PubMed1990

Complications of hepatic hydatid cysts: ultrasound, computed tomography, and magnetic resonance diagnosis.

A total of 179 hepatic hydatid cysts (HHCs) were studied by ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). The diagnosis of HHC complications was established by US and CT, which permitted a distinction between intact cysts and those presenting with contained rupture, as demonstrated by a collapsed endocyst or a globally echogenic appearance. The diagnosis of HHC perforation into the main biliary tree was made by detection of a discontinuity in the cyst wall and/or the presence of hydatid material within the biliary system. Similarly, direct HHC rupture into different thoracoabdominal spaces was diagnosed by demonstrating cyst wall discontinuity and the presence of hydatid material within these spaces. Ruptured and infected cysts were difficult to distinguish from ruptured cysts with sterile content. The role of MRI is yet to be defined in the assessment of HHC complications.

Adolescent↗
PubMed1990

[Measurement of the posterior wall of the intermediate bronchus. Diagnostic value].

The posterior wall of the intermediate bronchial trunk (PWIB) is visible in most cases on profile thoracic radiographs. A retrospective study showed that it is thickened (over 3 mm) in cases of cardiac failure, right pneumonitis, adenopathy, right bronchopulmonary neoplasias and pulmonary fibrosis, either acute or chronic. The latter etiology had not yet been described in the literature. In our experience, assessment of the thickness of the intermediate bronchus provides a reliable criterium of response to treatment. The pathological mechanisms of intermediate bronchus thickening due to an increase of bronchial wall thickness or of peribronchial interstitial tissue are discussed.

Bronchi↗
PubMed1989

Sonographic relationship between gallbladder wall thickness and the etiology of ascites.

Gallbladder wall thickness (GBWT) and serum albumin were determined in 54 patients with ascites. The statistical analysis of the results reveals a significant difference in GBWT between benign and malignant conditions (p less than 0.01). GBWT was significantly thicker in patients with cirrhosis than in those with malignant ascites (p less than 0.01) and other benign conditions. However, no significant differences were found between either cirrhotic cases with and without overlying hepatocarcinoma, or between noncirrhotic patients, malignant or otherwise. On comparing GBWT and simple routine sonography in establishing the etiology of ascites, the diagnostic reliability indices decreased with GBWT. This shows that GBWT determination lacks diagnostic importance in routine practice. No correlation was found between serum albumin and GBWT, which suggests that the increase in GBWT observed in cirrhotic patients is mainly the result of accompanying portal hypertension.

Ascites↗
PubMed1989

Value of sonography in true complete diphallia.

A case of true complete diphallia associated with multiple malformations is presented. Complete radiological evaluation should include sonography of both penes preoperatively to classify the penile duplication correctly.

Abnormalities, Multiple↗
PubMed1989

CT findings in Swyer-James syndrome.

Swyer-James syndrome (SJS) is usually diagnosed with plain chest radiographs obtained during inspiration/expiration. The authors studied patients with CT to assess its value in the evaluation of this syndrome. In patients with SJS, CT was useful in the determination of bronchial patency (all nine patients), lung parenchymal changes (subpleural infiltrates in six patients, atelectasis in two, and cavities in two), and the extent and degree of bronchiectasis (all nine patients). If CT is used for the evaluation of bronchiectasis, knowledge of the main findings associated with SJS (hyperlucent lung without anteroposterior gradient attenuation [n = 8], small lung [n = 6], and diminished central and peripheral pulmonary arteries [n = 9]) should facilitate the diagnosis of associated SJS. Expiration CT would support the diagnosis with demonstration of air trapping.

Adolescent↗
PubMed1988

CT diagnosis of primary mediastinal hydatid cyst rupture into the aorta: a case report.

Primary hydatid cyst of the mediastinum is rare. We report a patient with a primary mediastinal hydatid cyst which ruptured into the aorta, resulting in bilateral popliteal embolism. The contrast-enhanced computed tomographic features represent a pathognomonic sign of a communicating rupture of an echinococcal cyst into the aorta. Comparison is made with ultrasonography and aortography.

Adolescent↗
PubMed1987

[Isolated retroperitoneal hydatid cyst. CT study. Apropos of a case].

A 30 year old patient with isolated retroperitoneal hydatid cyst was the first case of this type to be studied by CT scanning. Isolated retroperitoneal hydatid cyst is defined as any zone of hydatidosis occurring in the fatty tissue of the spaces lying behind posterior parietal peritoneum, without any parasitic foci in other organs. Differential diagnosis from other primary retroperitoneal cysts has been improved by the availability of modern imaging procedures: ultrasonography and CT scan.

Adult↗