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Biomedical subjects

L Matos

Publications and source records attributed to L Matos.

At least 19 recordsLinked to original sources
PubMed1986

[Effect of heart diseases on premature labor].

The connection between the different heart diseases and premature births was studied. The incidence of premature births was more frequently in heart cases, while fetal retardation was similar to that of the control with exception of the group of the patients with acquired and operated heart diseases. Perinatal fetal mortality during birth was similar to the normal cases but higher in fetal retardation as in the general population of the pregnant women. In a worse condition of heart function the rates of premature birth, perinatal mortality and fetal retardation are more frequent than in a better circulatory state.--The contradiction found in the literature on this theme may have its cause that the effect of heart diseases affecting premature birth were not considered in its functional severity.

Adolescent↗
PubMed1981

A simple nonparametric procedure: the MAXIMIN test.

The MAXIMIN test is based on the principle that if two samples were drawn from the same population much overlapping of the values of the two groups would occur. However, if the two samples are drawn from two different populations, the values of Group 1 are expected to accumulate at one end of the numerical scale, whereas those of Group 2 will accumulate the other end. The sum of nG1 (the number of values in Group 1 greater than the greatest value in Group 2) and nG2 (the number of values in Group 2 smaller than the smallest value in Group 1) gives the MAXIMIN value (MV). The higher MV is, the smaller is the probability that the two samples contain different values by chance. The MAXIMIN test may provide a simple alternative to the t test as well as to other parametric and some nonparametric procedures for evaluating clinicopharmacological results.

Analysis of Variance↗
PubMed1981

[Congenital heart diseases and pregnancy (author's transl)].

The maternal foetal prognosis was studied on the basis of data which had been recorded from 56 pregnancies or deliveries of 46 women with congenital cardiac defects. Functional changes of circulation, such as hypoxia, pressure and volume overload, and conduction disorders, were assessed, with reference being made to the classification of the American Heart Association (AHA). In that context, the patients were repeatedly examined during pregnancy and followed up further through two years after delivery. --Maternal prognosis in pregnancy and, consequently, oxidation were found to depend on the kind of congenital heart disease. Reference is made to the favourable role played by cardiac surgery in preventing cardiac complications. Premature birth and retarded foetal development have occurred repeatedly, depending on severity of a congenital heart disease. Enzymological-histological tests are likely to suggest that such consequences were primarily attributable to strongly impaired placental energy production on account of inadequate haemodynamic conditions of the mother. --Proper prognostication of pregnancy will depend for high standards on adequate supervision of delivery, prophylactic use of caesarean section, individual assessment of any single case, and efficient teamwork of obstetricians and cardiologists.

Adult↗
PubMed1976

Effects of lidocaine on myocardial function and on isoprenaline-induced circulatory changes in man.

14 non-cardiac patients aged 42 to 71 years (mean 49 years) were studied. Part I 1 mg/kg or 2 mg/kg of lidocaine were administered i.v. on two consecutive days and systolic time intervals (STI) were obtained at one minute intervals for 30 minutes. No change in STI was observed after lidocaine injection. In Part II, a bolus of 5 mug of isoprenaline was given i.v. before and after an injection of 2 mg/kg of lidocaine. Isoprenaline caused a highly significant increase in the heart rate, shortening of the total electromechanical systole, pre-ejection period, electromechanical delay, isovolumic contraction time as well as PEP/LVET and ICT/QS1, indices (in all cases p less than 0.001). 2 mg/kg lidocaine had no blocking or potentiating action on the catecholamine-induced circulatory changes. In Part III, after the isoprenaline challenge, a dose of 2 mg/kg of lidocaine was administered and the bolus injection was followed by an infusion of 30 mug/kg/min. Lidocaine per se caused no change in STI in the course of the infusion over 90 minutes, and there was no difference between isoprenaline-induced changes in STI before and during lidocaine infusion. These results suggest that lidocaine has no negative inotropic effect in the therapeutic dose range in man. Lidocaine caused no change in the systolic time intervals, it had no blocking or potentiating action on the isoprenaline-induced circulatory changes, and it had no negative inotropic effect in therapeutic doses in man.

Adult↗
PubMed1976

[Early and late effects of the gestational course following commisurotomy].

Early and late effects of pregnancy on the cardio-vascular system and on the outcome of the pregnancy were studied in 82 women after commissurotomies. According to the clinical and instrumental investigations the burden of pregnancy may only be temporary and might cause no demonstrable damage on case of careful supervision of specialists before, during and after pregnancy and if there is a considerate delivery. Due to the higher number of "small for date babies" the fetal perinatal mortality rate and premature births are higher than in the general population. The higher incidence of "small for date babies" seems to be related to a decrease of the function of placenta in cases of premature delivery. Further improvement of matermal and foetal results is expected from perfecting diagnostic methods and from a better coordination of the team work of heart surgeons, cardiologists and gynaecologists.

Abortion, Threatened↗
PubMed1975

Comparative study of the cardiac and peripheral vascular effects of strophantin K and lanatoside C in coronary heart disease.

The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the lying position after both glycosides and placebo; the systemic blood pressure remained unchanged. Electromechanical systole (QS2), left ventricular ejection time (LVET) and preejection period (PEP), corrected for heart rate (QS2I, LVETI, PEPI), showed no change after placebo. The glycosides caused no change in LVETI. QS2I was significantly shortened only after lanatoside C 1.6 mg. PEPI and ICT were significantly shortened by both doses of strophanthin K and lanatoside C; the effects were dose-related. Taking into consideration the effects of cardiac glycosides on STI, use of the index ICT/QS1, the quotient of isovolumic contraction time and electro-mechanical delay, is proposed, because it showed quite sensitively the increase in myocardial contractility after digitalis. The effect of strophanthin K could be detected 10 minutes, and that of lanatoside C 30-40 minutes, after injection. The amplitude of the IP curve and the relative pulse volume showed positive and negative changes without any trend after administration of placebo or glycoside. The data suggests that the usual therapeutic doses of these cardiac glycosides do not cause significant changes in the peripheral circulation in patients with compensated coronary heart disease, but their action on STI is quite marked, showing a positive inotropic effect.

Adult↗