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Biomedical subjects

L Mauro

Publications and source records attributed to L Mauro.

6 recordsLinked to original sources
PubMed1991

Immune response to simultaneous administration of a recombinant DNA hepatitis B vaccine and multiple compulsory vaccines in infancy.

The reactogenicity and immunogenicity of simultaneous administration of recombinant DNA hepatitis B vaccine with diphtheria and tetanus toxoids (DT) and oral poliovirus vaccine (OPV) in 111 infants were compared with those of DT and OPV alone in a control group of 21 infants. All subjects received three doses of the vaccine according to one of three different schedules of vaccination. Reactions following simultaneous administration of vaccines were all but absent, with mild pain reported for four out of 111 subjects, compared with one of 21 in the control group. Seroconversion rates of 98-100% and high anti-HBs geometric mean titres (GMTs) were observed in all study groups after three doses of hepatitis B vaccine. Significantly higher anti-HBs were seen in Group III, where six months is allowed between the second and the third hepatitis B vaccine doses, compared with Group I and II, where only 1-2 months separate the second and third doses. A fourth dose of vaccine was needed in both these groups to obtain anti-HBs levels as high as seen in Group III after three vaccine doses at 3, 4 and 10 months of age. The immune response to DT and OPV was similar in the study groups and the control group. It is concluded that a course of 10 micrograms doses of recombinant hepatitis B vaccine given simultaneously with DT and OPV elicits a strong anti-HBs response and does not interfere with the immune response to the other antigens.

Antibodies, Viral↗
PubMed1991

Simultaneous administration of HB recombinant vaccine with diphtheria and tetanus toxoid and oral polio vaccine: a pilot study.

An extensive vaccination program to be used in highly endemic areas is the main strategy against the spreading of hepatitis B. The purpose of this study was the evaluation of the immune response to the recombinant HB vaccine administered singly or at the same time as other compulsory vaccines anti-diphtheria, anti-tetanus and oral anti-polio. Evidence was found of the serological efficacy both of HB vaccine and compulsory vaccines with a percentage of seroconversion of 100%. However, the infants who received HB vaccine at birth and at the age of 1 month had titers of antiHBs higher than the infants who received HB vaccine at birth and at 3 months. No difference in antibody levels of compulsory vaccines was observed among the study groups and the controls who received only compulsory vaccines. Our results suggest that HB vaccination must be encouraged and pursued in all newborns.

Diphtheria Toxoid↗
PubMed1977

Granulocyte function in visceral leishmaniasis.

Nitroblue tetrazolium test in nine children with visceral leishmaniasis (VL) showed no increase of spontaneous reduction by neutrophils. The normal bactericidal activity of four of these patients excludes an impaired function of the neutrophils in VL.

Blood Bactericidal Activity↗
PubMed1976

Leukocyte function and characterization of leukocyte glucose-6-phosphate dehydrogenase in Sicilian mutants.

Nine Sicilian children known to be deficient in glucose-6-phosphate dehyrdrogenase (G6PD) were studied to see if there were anomalies of bactericidal activity in peripheral blood phagocytes. The type of deficiency was established. The G6PD levels in the leukocyte were found to be 26% of the controls (0.094 +/- 0.03, normal controls 0.360 +/- 0.12). The Michaelis constant for NADP and glucose-6-phosphate (G6P) was lower than the control. Conversely, the utilization of the analogous 2-deoxyglucose-6-phosphate (2dG6P) and galactose-6-phosphate (Ga16P) was higher. The thermostability of the enzyme in the deficient subjects was lower and the pH optima (8 and 9.5) were different from the controls. An identical electrophoretic pattern was found in both normal and deficient subjects. The bactericidal activity in the deficient subjects was normal. There was no difference in the results of nitroblue tetrazolium (NBT) tests in either group.

Blood Bactericidal Activity↗
PubMedDate not supplied

HTLV-I and HIV-I antibody frequency in thalassemics and drug addicts in southeast Sicily.

HTLV-I (Human T-Lymphotropic Virus Type 1) and HIV-1 (Human Immunodeficiency Virus Type 1) antibodies have been investigated in 702 sera samples from: 259 drug addicts nerve screened for HIV-1 (Group I), 43 drug addicts already identified as HIV-1 seropositive (Group II), 222 thalassemics (Group III) and 178 occasional blood donors (Group IV). The sera, collected from June 1984 to April 1989, were screened a first time with immunoenzymatic test and the samples proving positive were then confirmed by Western blot test. The seropositive frequency with Western blot for anti-HTLV I was 2.7% in Group I and 6.9% in Group II. Of the thalassemics, five of whom had been previously identified as seropositive for HIV-1, and of the blood donors, none proved to be seropositive for HTLV-I antibodies. With regard to HIV-1, a positive antibody response to the Western blot was found in 19.9% of the Group I subjects. Contemporaneous presence of HTLV-I and HIV-1 antibodies was found in five subjects.

Adolescent↗