PubMed Health⌕ Search

Biomedical subjects

L McGowan

Publications and source records attributed to L McGowan.

9 recordsLinked to original sources
PubMed1991

Pathology of the ovary.

Recent medical articles on pathology of the ovary have contributed to a better understanding of ovarian cancer. Postmenopausal women with ovarian neoplasms, especially bilateral ones, are at great risk that they are malignant. Methods for histologic and frozen-section sampling of ovarian neoplasms may vary from one pathology laboratory to another. Primary peritoneal cancer is a distinct clinical entity and all physicians operating on women with pelvic cancers should be alert for its presence. Serum CA 125 analysis may be of value in determining whether to carry out a second-look operation in women with epithelial ovarian cancer. The influence of rupture of the capsule of epithelial ovarian tumors, hydronephrosis, and disease limited to the ovaries and survival are discussed.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1991

The mistaken diagnosis of carcinoma of the ovary.

The primary site of carcinoma was investigated in 339 women diagnosed as having carcinoma of the ovary. After a review of medical records and microscopic slides, 43 women were discovered not to have a primary carcinoma of the ovary. Of these 43 women, 15 had benign ovarian tumors, 13 had primary carcinoma of the peritoneum and 15 had primary carcinoma of the intestines. Review of the medical records of 15 women found to have benign ovarian tumors disclosed the original pathologic interpretation of cancer was not supported by clinical or operative observations and no second opinion pathologic review was noted in the records. Until our review, 13 women who were diagnosed as having carcinoma of the ovary had primary peritoneal tumors. Nine of these women either had normal ovaries removed previously or had normal results of biopsies of the ovary done intraoperatively. Of those women entering the study with a diagnosis of carcinoma of the ovary, but in whom our review noted carcinoma of the intestines, 14 of 15 had intestinal complaints before operation. More than one-half of the patients did not have the intestine studied preoperatively, most had diffuse disease at operation and almost one-half of the women had normal sized ovaries at operation. By not performing gastrointestinal roentgenographic studies and suspecting the possibility of metastasis and by misleading the pathologist by presenting the specimen as an ovarian tumor, patients were erroneously diagnosed as having primary carcinoma of the ovary.

Adult↗
PubMed1975

Peritoneal fluid profiles.

Peritoneal fluid in women is very sensitive to many physiologic and pathologic gynecologic and obstetric conditions. Peritoneal fluid specimens can be obtained from women easily by culdocentesis. Routine assay for the presence or absence of malignant cells in peritoneal fluid from women with early ovarian cancer is indicated to determine the prognosis for the patient and the necessity for further therapy. The serial cytologic and biochemical evaluation of peritoneal fluid seems to be the best currently available means to determine persistent or recurrent ovarian cancer as well as to monitor therapy in a woman with normal clinical and roentgenographic examinations.

Animals↗