Biomedical subjects

L McGrew

Publications and source records attributed to L McGrew.

3 recordsLinked to original sources

PubMed2002

Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits.

Phospholipase D activation was measured in primary cultures of rat choroid plexus epithelial cells, which endogenously express the 5-hydroxytryptamine (5-HT) 2C receptor, as well as a heterologous cell line expressing the cloned receptor. In both systems, serotonin stimulation of the 5-HT(2C) receptor activates phospholipase D in addition to phospholipase C, the traditional effector. Specific inhibitors and membrane permeable blocking peptides were used to determine which heterotrimeric G-proteins were involved. Results suggest that both alpha and free betagamma subunits from G(13) heterotrimers are responsible for phospholipase D activation.

3T3 Cells↗

PubMed1985

The Landau reaction in fullterm and preterm infants at four months of age.

Twelve normal fullterm infants and 11 low-risk preterm infants were assessed at four months of age. Assessments included a Three-Component-Scale for the Landau reaction, the Touwen Scale for the Landau reaction, the Bayley Scales of Infant Development Motor Scale, and the Movement Assessment of Infants Muscle Tone Scale. A statistically significant relationship was found between gestational age (preterm vs. fullterm birth) and scores on the hip and kicking subcomponents on the Three-Component-Scale for the Landau reaction, and also between gestational age at birth and scores on the summary of tone-extremities and total risk score items on the Movement Assessment of Infants. Although preterm and fullterm infants may not show differences in scores on motor developmental level assessments, variations in postural reactions and muscle tone may be present at four months of age.

Female↗

PubMed1983

Motor assessment tools: their concurrent validity in evaluating children with multiple handicaps.

Three developmental motor assessment tools were administered concurrently to 17 children with severe multiple handicaps in an effort to examine the relationship of developmental age equivalent scores among the 3 tools. The Bayley Scales of Infant Development, a standardized and norm-referenced infant assessment tool, was used as criterion for concurrent validity in evaluating the other 2 tools, the Callier-Azusa Scale and the Fircrest Deaf-Blind Motor Assessment Tool. In spite of variations in quantity and type of behaviors assessed on each of these 3 instruments, highly significant positive correlations were shown between age equivalent scores on the Bayley and those on each of the other 2 tests. These findings support the application of objective, quantifiable measurement tools for determining developmental motor age levels of severely disabled children with multiple handicaps.

Adolescent↗