The uptake and distribution of zinc in tissues and the effects of 2500 ppm dietary zinc oxide on health, faecal microflora, and the functions of circulating neutrophils were evaluated in weaned pigs. One group was fed a zinc supplement diet and another group was used as a control. All pigs remained healthy throughout the study, but the supplemented animals showed better performance than the controls. The serum zinc values rose rapidly. At autopsy, carried out at the age of 63 days, the zinc concentrations in liver tissue were 4.5 times higher, and in renal tissue two times higher in the supplemented group than in controls (P<0.001). Microscopic examination showed increased lipid accumulation in hepatocytes from supplemented pigs. No effect on the number of excreted Escherichia coli and enterococci per gram faeces or on the functions of circulating neutrophils was observed. Dietary supplementation with 2500 ppm ZnO for up to two weeks after weaning appears to be potentially beneficial in the prevention of postweaning diarrhoea in pigs.

Animal Feed↗

PubMedDate not supplied

Effects of a broad-spectrum behavior modification treatment program on children with refractory epileptic seizures.

A group of 18 children with refractory epileptic seizures was divided into three groups--behavior modification treatment, attention control, and control groups--with the purpose of investigating the effects of a learning-based broad-spectrum treatment program superimposed on a regular medical treatment program. The design consisted of a 10-week baseline, 6-week intervention, and 10-week and 1-year follow-ups. A combination of number of seizures and seizure duration--termed "seizure index"--was used as a dependent measure. There was a significant reduction in seizure index only for those children receiving the behavior modification treatment, at both follow-ups. The results indicate that this behavioral treatment program may be of substantial help to children with epilepsy who are resistant to conventional drug therapy.

Adolescent↗

PubMedDate not supplied

Effects of a contingent relaxation treatment program on adults with refractory epileptic seizures.

A group of eighteen adults with refractory epileptic seizures were given psychological treatment in a two-phase experimental group study. In phase one, the experimental phase, the patients were divided into three groups--contingent relaxation (CR), attention control (ATC) treatment, and a no-treatment (NT) control group--with the purpose of investigating the effects of a learning-based contingent relaxation program compared with the effects of professional attention alone when superimposed on a regular medical treatment program. The design of the experimental phase was comprised of a 10-week baseline, 6-week intervention, and 10-week follow-up. Results of this phase at the end of follow-up showed a significant reduction only for those patients receiving the CR treatment. In the nonexperimental phase, the two control groups also received the CR treatment for a 6-week period, and subsequent seizure frequency measures for all three groups were analyzed after 10-week and 30-week follow-up periods. Results of this phase showed a significant reduction in seizure frequency for all three groups after receiving the CR treatment. Effects of the CR treatment were maintained at a 30-week follow-up. The results indicate that the CR treatment program may be of substantial help to adults whose seizures are resistant to conventional drug therapy.

Adult↗

PubMedDate not supplied

Effects of a behavioral intervention on epileptic seizure behavior and paroxysmal activity: a systematic replication of three cases of children with intractable epilepsy.

Three children with very frequent refractory epileptic seizures underwent a behavioral intervention consisting of symptom discrimination, countermeasures, contingent relaxation, and positive reinforcement for correct responses in a systematic replication series. The studies involved a 6-h nonintervention base rate, a 6-h treatment phase, and a 6-h nonintervention follow-up under laboratory conditions for each child. Neurophysiologic and behavioral measures of the effects of treatment were made using electroencephalogram (EEG)-video equipment. Effects of treatment were assessed by using a random sample of EEG-video sequences in base rate and follow-up. Results showed that no significant reduction of either seizure behavior or paroxysmal EEG activity was found subsequent to training in discrimination of early paroxysmal activity and/or sensations preceding seizures. Both seizure behavior and paroxysmal activity were significantly reduced in all three cases following intervention with an adapted countermeasure technique. No additional effects could be noted subsequent to the application of either contingent relaxation or positive reinforcement for correct responses. Paroxysmal EEG changes and seizure behavior were highly correlated. Reduction of the clinical manifestation or seizure response by behavioral manipulation was accompanied by a reduction of the total amount of paroxysmal activity as measured by the EEG.

Adolescent↗

PubMedDate not supplied

Effects of a broad-spectrum behavioral medicine treatment program on children with refractory epileptic seizures: an 8-year follow-up.

We present an 8 year follow-up on a group of children with refractory epileptic seizures who participated in the early 1980s in a controlled group study on the effects of a broad-spectrum behavior modification treatment program on children with refractory epileptic seizures. In the original study, 18 children were divided into three groups: behavior modification group, attention control group, and control group. The purpose was to investigate the effects of a learning-based treatment program superimposed on a regular medical treatment program. Also, the effects of professional attention were evaluated. At the 10 week and 1 year follow-ups, only the group receiving the behavior modification intervention had a significantly reduced rate of seizure index. The present study investigates these same children 8 years later using the same methods of investigation for an additional 10 week period. The results indicate that a significant reduction in seizures was obtained only for the behavior modification group at the 8 year follow-up.

Adolescent↗

PubMedDate not supplied

Control and dispositional style among the hearing-impaired in communication situations.

Forty hearing-impaired subjects were exposed to three stressful communication situations in a laboratory setting. The communication patterns used and the extent to which the subjects succeeded in coping with the situations were studied. Measures, such as the life orientation test measuring dispositional style, a hearing questionnaire measuring the ability to cope with different hearing situations, degree of control and pure-tone audiometry were performed. Coping behaviour and expressed emotion during communication situations were also observed. The results showed that controllability together with dispositional style and aspects of expressed emotion played an important role in explaining the overall success rates of hearing-impaired individuals.

Adaptation, Psychological↗

PubMedDate not supplied

Dispositional optimism, dysphoria, health, and coping with hearing impairment in elderly adults.

Sixty-eight elderly hearing impaired subjects were interviewed and completed self-report measures on hearing disability, dispositional optimism, dysphoria, and general health. The measures used were the Hearing Coping Assessment (HCA), the Hearing Questions (HQ), the Life Orientation Test (LOT), The Beck Depression Inventory (BDI), and a subscale from the Göteborg Quality of Life (GQL). Psychometric analyses of HCA, HQ, LOT, BDI, and GQL revealed high reliability in terms of Cronbach's Alpha and split-half r's. Significant intercorrelations were found between several measures, but not with pure-tone audiometry (0.5, 1, 2, and 3 kHz). Cluster analysis was used to identify subgroups in the sample. As a result three clusters were identified interpreted as 'high copers', 'copers with moderate psychological and somatic complaints', and 'low copers'. Results from the cluster analyses were confirmed by using two different clustering methods and by between-cluster comparisons on the HQ, which had not been used to obtain the clusters.

Adaptation, Psychological↗