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Biomedical subjects

L Mendelson

Publications and source records attributed to L Mendelson.

At least 37 records · Page 2Linked to original sources
PubMed1984

Pollen-specific IgG antibodies in the tears of patients with allergic-like conjunctivitis.

Specific-IgG antibodies to rye grass and/or AgE in the tear secretions were demonstrated in studies of patients with the clinical features of allergic conjunctivitis but negative immediate skin reactivity and absent IgE antibodies by RAST to the inhalant pollen allergens. Studies by use of transferrin as a marker for the vascular leakage of plasma proteins into the tear secretions indicated that more than 98% of these pollen-specific IgG antibodies were locally produced by the conjunctival tissues of the external eye. These findings suggest that IgG-mediated immune mechanism(s) are important in the pathogenesis of some patients with allergic-like conjunctivitis.

Adolescent↗
PubMed1983

IgG specific antibodies to rye grass and ragweed pollen antigens in the tear secretions of patients with vernal conjunctivitis.

We studied the tears of 30 patients (25 males and five females, ranging in age from 8 to 34 years) with vernal conjunctivitis for pollen-specific IgG antibodies to rye grass and ragweed antigen E by an enzyme-linked immunosorbent assay (ELISA). Eighteen of 30 (60%) and 20 of 30 (67%) patients with vernal conjunctivitis had significant levels (more than 2 S.D. from the mean of control tears) of IgG antibodies in their tear secretions to rye grass (geometric mean = 68.7 ELISA units) and ragweed antigen E (geometric mean = 50 ELISA units), respectively. In contrast, the control groups (eight atopic individuals, four with seasonal rhinitis, and 12 with allergic conjunctivitis) had low amounts of specific IgG antibodies to these two pollen antigens in their tears. Total IgG and IgM were also increased in the tears of patients with vernal conjunctivitis. To evaluate whether these immunoglobulins and specific IgG antibodies were locally produced by the conjunctival tissues, we used transferrin as a marker for the leakage of plasma proteins into tears. We found that the specific IgG antibodies to rye grass or ragweed antigen E, or both, in the tears were locally produced by the conjunctival tissues. The local production ranged from 20% to 99.9%. Of 17 patients with vernal conjunctivitis and undetectable pollen-specific IgE antibodies in their tears, 14 (82.4%) had tear specific IgG antibodies to rye grass or ragweed antigen E or both, whereas of those with measurable tear IgE antibodies, only nine of 13 (69%) had tear IgG antibodies to rye grass or antigen E or both. These results suggested that both IgE- and IgG-mediated immune mechanisms may be important in the pathogenesis of vernal conjunctivitis.

Adolescent↗
PubMed1983

A comparison of cromolyn and bronchodilators in patients with mild to moderately severe asthma in an office practice.

The efficacy and safety of two treatment regimens, based in the one case on cromolyn and in the other on bronchodilators, were compared in an eight week study in predominantly young, mild to moderate asthmatics in an office practice. We utilized subjective and objective measures of assessment. Cromolyn was as effective as the bronchodilator regimen except in terms of asthmatic cough, which was better controlled by cromolyn. An equal number of patients could not tolerate each regimen and were dropped from the study. Among those who continued and completed the study cromolyn was devoid of adverse effects whereas 62% of the patients maintained on theophylline with or without a concomitant beta-agonist reported side effects. The results of this preliminary study and of our subsequent broader clinical experience suggest that a re-evaluation of the current approach to managing the symptoms of chronic asthma is indicated, at least in pediatric patients.

Adolescent↗
PubMed1980

Rehabilitation outcome of brain damaged patients after severe head injury.

The multidisciplinary team approach to the prolonged treatment of head injured patients in widely discussed. The rehabilitation process of the 147 subjects of this paper started while they were comatose and continued throughout the various stages of their progress towards full integration into society; the assessment of this process was carried out by testing their reintegration into work according to their capacities. Brain damage is classified in four categories: Physical-locomotor, communicative, cognitive and behavioural. The gap between the team's expectations and the patients' factual functioning within the community was found to be proportional to the extent of damage caused by the original injury. Treatment procedures and the influence of various factors on the factual functional state are discussed at length.

Adolescent↗
PubMed1980

Herpes virus hominis encephalomyelitis and retinal vasculitis in adults.

The cases of two adults who developed viral encephalomyelitis are presented. The diagnosis of herpes virus hominis infection was made as a result of the rising titers of herpes virus on indirect fluorescence tests in the serum and the cerebrospinal fluid. Both patients developed retinal vasculitis with retinal edema and hemorrhages. The importance of follow-up examinations of the fundus is stressed to avoid rhegmatogenous retinal detachment caused by retinal tears.

Aged↗
PubMed1978

Pulmonary functions and responses to exercise of patients following cranio cerebral injury.

To assess the causes of excessive fatigue among patients who have recovered from cranio-cerebral injury (CCI) nineteen patients and fourteen healthy controls underwent pulmonary function testing at rest and cardiopulmonary evaluation during two submaximal exercise work-loads. Total lung capacity, vital capacity and forced expired volume were reduced by 25--40% among the patients. Functional residual capacity was normal. No improvement was elicited by inhalation of Ventolin and bronchoconstriction could thus be excluded. The above pattern may result from either decreased compliance of the chest wall or from weak (or non-coordinated) respiratory musculature. Exercise heart rate, minute ventilation and ventilatory equivalent were higher, and O2 pulse lower, among the CCI patients compared with the controls. This indicates lower circulatory and ventilatory efficiency during exercise among the patients, possibly due to habitual hypoactivity and detraining.

Adult↗
PubMed1977

Homonymous hemianopsia and rehabilitation in fifteen cases of C.C.I.

Fifteen cases of severe cranio-cerebral injuries (C.C.I.) with hemianopsia and rehabilitation problems are presented. The correlation between the side of the hemianopsia, dexterity, visual motor organization, intellectual functions and rehabilitation outcome are discussed.

Brain Injuries↗
PubMed1977

The effects of message speed on auditory comprehension in patients with cerebral cranial injury.

A brief preliminary report is presented on the effects of varying the speed of a spoken message on the performance of motor tasks by patients with cerebral cranial injury. The token test for aphasia was recorded at three different speech time compression/expansion ratios, then presented under sound field (loudspeaker) conditions to three groups of subjects, one of normal young adults as a control, the second of patients with cerebral cranial injury without evidence of aphasia, and the third containing CCI patients with aphasia. Results are reported for speech speed increases (compression) of 25% and 50% and for a speed decrease (expansion) of 35%.

Aphasia↗
PubMed1975

Prognostic factors in rehabilitation after severe head injury. Assessment six months after trauma.

After initial neurosurgical treatment, 40 patients who regained consciousness 1 to 90 days after major cerebral trauma, were admitted for rehabilitation. Six months after their injury they were assessed in terms of: 1) Locomotor function, 2) Intellectual performance, 3) Communication disorder, and 4) behaviour disturbances. The usefulness of these parameters as prognostic factors in rehabilitation is discussed. Eight patients without significant disabilities in all 4 parameters returned to normal life. Patients who showed locomotor, communicative and behaviour impairment but no gross intellectual deficits, were considered capable of being retrained. The poorest prospects for social and vocational rehabilitation were found in 15 patients with cognitive defects.

Adult↗
PubMed1975

Periarticular new bone formation in patients suffering from severe head injuries.

A total of 35 cases of periarticular new bone formation (PNBF) was observed among 160 patients with coma following severe craniocerebral trauma. All cases were associated with blunt trauma and none with penetrating wounds. Only 6 of 500 cases of acute non-traumatic hemiplegia developed PNBR, and all 6 of them followed craniotomy, brain surgery and coma. New bone formation first appeared mainly between 50 and 120 days after craniocerebral injury with prolonged coma. Three-quarters of the patients with PNBF showed involvement of the shoulder joint, but this was not associated with previous subluxation. Metabolic studies were done in some patients; no disturbances were found in the metabolism of calcium, phosphorus or alkaline phosphatase. The pathologic process of PNBF seemed to stabilize some 6 to 8 months following trauma, and surgery after this period produced functional improvement in the 3 patients in whom it was tried. No satisfactory pathophysiological explanation has been found for the phenomenon of PNBR. Prolonged coma is common to all patients who suffered from PNBF and is probably an etiologic factor. The absence of PNBF in cases of cerebrovascular accident with subluxations of the gleno-humeral joint and intensive physiotherapy seems to contradict the suggestion of microtrauma as an etiological factor.

Adult↗