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Biomedical subjects

L Milkovich

Publications and source records attributed to L Milkovich.

11 recordsLinked to original sources

Self-measurement of blood pressure: accuracy, patient preparation for readings, technique and equipment.

OBJECTIVE: Self-measurement of blood pressure is commonly performed by those persons with hypertension and is advocated in many national hypertension guidelines. We examined accuracy of readings, patient knowledge, and preparation for readings, technique and equipment. DESIGN: The study was a prospective observational design. Sixty-nine hypertensive patients were recruited from a tertiary referral center and by newspaper advertisement. All patients had previously self-measured their blood pressure. The patients initially measured their blood pressure under direct supervision in a clinic using their usual preparation, technique and their own equipment. Then after a five-min rest, blood pressures were measured twice both by research nurse and the patient in an alternating sequence. The nurse used a standardized blood pressure measurement technique. RESULTS: Inadequate patient knowledge and performance of measurement technique and inaccurate equipment was common. The average initial patient systolic reading prior to the five-minute rest was higher than that of the trained nurse (9.1 +/- 13 mmHg systolic, p < 0.001 and 1.5 +/- 8.0 mmHg diastolic, p = 0.12). Almost half (42%) of the initial patient blood pressure readings differed in classification of hypertension/normotension from the nurse. The difference between the patient and nurse readings after the five-min rest was 3.8 +/- 11.8 / 1.1 +/- 6.8 mmHg. CONCLUSIONS: Care must be taken in interpreting patient self-measured blood pressure unless there has been adequate training and assessment of patient and equipment accuracy. Studies of health care professionals reveal similar problems therefore widespread efforts to standardize blood pressure measurement are necessary.

Aged↗

Self-measurement of blood pressure: benefits, risks and interpretation of readings. The Canadian Coalition for High Blood Pressure Prevention and Control.

The literature on the benefits and risks of self-measurement of blood pressure and interpretation of the readings was reviewed. Self-measurement of blood pressure is useful in selected patients with high blood pressure, can be used to monitor blood pressure closely outside health care facilities, and can determine whether patients have white coat hypertension. The involvement of patients in their own blood pressure management is increased and self measurement may result in more rapid achievement of target blood pressure readings, improvement in adherence to antihypertensive therapy and decreased health care utilization. However, some patients may not be suited to monitor their own blood pressure and some may experience an increase in anxiety regarding their health. With careful training and selection of patients, most can accurately assess their blood pressure. Self-measured readings are generally lower than readings in a physician's clinic (or office) and this must be accounted for in assessing response to therapy and usual levels of blood pressure. Self-measured readings are a valuable supplement to clinic readings in many patients.

Anxiety↗

The relationship between hormonal pregnancy tests and congenital anomalies: a prospective study.

In a prospective study of some 20,000 pregnancies in the Child Health and Development Studies in the San Francisco East Bay area, 226 gravidas were tested for pregnancy with estrogen/progestogen preparations. The two control groups were women who were tested for pregnancy by either a serum or urine test. There were no statistically differences (p greater than 0.05) in the rates of severe congenital anomalies between the hormone test group and the two control groups. The relative risks and the 95% confidence intervals were 1.01 (0.47-2.19) for the hormone/serum test comparison and 1.60 (0.60-4.18) for the hormone/urine test comparison.

Abnormalities, Drug-Induced↗

Incidence of congenital anomalies among white and black live births with long-term follow-up.

The incidence of congenital anomalies at birth and accumulated to five years is presented for live-born children in a large prospective study. Congenital anomalies are not all diagnosable at birth; our data demonstrate that the incidence rate increases approximately three-and-one-halffold for Blacks and approximately fivefold for Whites between six days of age and five years of age. The incidence of congenital anomalies at birth was higher among Black children than White children, but there were no notable differences between the groups in incidence accumulated to age five years. At five years, the incidence rate of severe and moderate (but not trivial) congenital anomalies amounted to 15 per cent; for severe congenital anomalies, 4 per cent. Severe congenital anomalies diagnosed through age five years were observed to have a much higher incidence among children who weighted 2500 gm or less at birth than among those who were heavier.

Black People↗

Effects of antenatal exposure to anorectic drugs.

In a large prospective, observational study of pregnancy and child development, the anorectic drugs (amphetamines and phenmetrazine) prescribed to gravid women during different stages of pregnancy were evaluated for their teratogenicity. The severe congenital anomaly rate (SCA) per 100 live-born children at age five years did not differ from the SCA rate of the group of children whose mothers did not use these drugs. There was, however, an excess of oral clefts in the offspring of mothers who had amphetamines prescribed in the first 56 days from the last menstrual period. A rought test of efficacy of anorectic drugs by comparing mean weight gains in four-week periods before and after the prescription showed only short-term and limited reduction of weight gain.

Abnormalities, Drug-Induced↗

An evaluation of the teratogenicity of certain antinauseant drugs.

In a large, prospective, observational study of pregnancy and child development, the antinauseant drugs prescribed to gravides for nausea and vomiting in the first 84 days of pregnancy were evaluated for their teratogenic potential. The severe congenital anomaly rates per 100 liveborn children and ther perinatal death rates of this group did not differ from the rates of the group with untreated nausea and vomiting. There was no indication that the phenothiazine derivatives, specifically the prochlorperazine derivative, as well as meclizine, cylizine, and Bendectin were associated with teratogenicity. The trimethobenzamide drug gave a slight suggestion of an excess of severe congenital anomalies.

Abnormalities, Drug-Induced↗