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Biomedical subjects

L Miro

Publications and source records attributed to L Miro.

12 recordsLinked to original sources

Hypertrophic cardiomyopathy in mucopolysaccharidoses: regression after bone marrow transplantation.

Mucopolysaccharide storage disease (MPS) presents clinically with a broad spectrum of abnormalities, among which cardiovascular involvement has been described. The echocardiographic findings have recently been reported for the various types of MPS. Among these, asymmetric septal hypertrophy (ASH) has been documented. We present a case of a 9-year-old girl suffering from type I MPS, atypical variant, with echocardiographic signs of ASH. She was given a bone marrow transplant after which the hypertrophic cardiomyopathy regressed.

Bone Marrow Transplantation

[Scanning electron microscope view of dentin exposed to CO2 laser radiation].

In order to better define the effects of CO2 Laser rays on dentine, 10 healthy human teeth to be removed and 64 recently removed healthy human teeth were prepared and irradiated according to the classic protocol used in clinical periodontics, and observed with a scanning electron microscope. The examination of these samples confirms the phenomena of dentin fusion and recrystallization. But these alterations result in the appearance of a reorganized superficial layer consisting of unevenly juxtaposed craters formed by the pin-point action of the laser beam. These craters present numerous fissures and openings of variable diameter. They do not form a homogeneous surface, since chips may be raised, demonstrating the fragility of the reorganized layer and a lack of cohesion of the underlying dentine. The modified dentine layer also disappears when a curette is used, revealing a very uneven surface crossed with small cracks and where the tubule openings become visible. Our results, unlike many more optimistic studies, still prompt us to exert caution in the systematic use of CO2 lasers in Periodontics.

Adult

[Laser applications in medicine and surgery (author's transl)].

After an analysis of the complex interweaving reactions of laser on biological materials, the laser applications in medicine and surgery are reviewed by the author. In ophthalmology its use is regular but not yet optimal. In otological applications the first results are good. In dermatology favorable results are obtained but the absence of special device had stopped his development. In surgery and endoscopy the best wave length must be chosen in reference to their hemostatic action and cutting, nevertheless in gastroscopy and bronchoscopy the laser seems to bring new therapeutic solutions. In odontology the pulsed lasers are dangerous for therapy but the holographic technique is a fertile research area. The author conclude to the necessary development of researches on the fundamental problems set by the biomedical applications of lasers.

Animals

[Use of a flexible laser-beam (Yag) for endoscopic treatment of some tracheobronchial lesions (author's transl)].

After the use for several years of an endoscope which enables electro-coagulation in the treatment of some tracheo-bronchial lesions, the limitations and accidents of this method were compared with clinical results and experimental research. Results seem to indicate that the flexible laser beam can considerably improve therapeutic possibilities. This beam, conducted by a flexible fiber, could easily be used by medico-surgical teams who already possess the suitable endoscopic material, or material that could readily be adapted to this method.

Bronchial Neoplasms

[Use of a laser beam (YAG) with a flexible fiber for endoscopic treatment of some broncho-tracheal lesions (author's transl)].

For several years we employed an endoscope permitting electro-coagulation in the treatment of some broncho-tracheal lesions and were able to observe the limits and accidents involved in this method. When compared with clinical results (work of Freche in ORL, laser CO2) and after experimental research, the use of a flexible laser beam (YAG) seems to bring about a noteworthy increase in therapeutic possibilities. This flexible fiber beam could easily be used by some medico-surgical teams who already possess appropriate of easily adaptable endoscopic equipment. Clinical studies are in progress.

Animals