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Biomedical subjects

L Missotten

Publications and source records attributed to L Missotten.

At least 73 records · Page 4Linked to original sources
PubMed1994

Efficacy and safety of indomethacin 0.1% versus flurbiprofen 0.03% eyedrops in inflammation after argon laser trabeculoplasty. The Belgian Study Group on Glaucoma.

After Argon Laser Trabeculoplasty (ALT), non steroidal anti-inflammatory drugs (Indomethacin 1% suspension and Flurbiprofen 0.03% solution) were shown to be efficient in the management of post laser inflammation. To evaluate the efficacy and safety of Indomethacin 0.1% solution versus Flurbiprofen 0.03% eyedrops in that purpose. 64 patients suffering from glaucoma were recruited in a multicenter randomized double masked study. The results demonstrate that Indomethacin 0.1% eyedrops is as efficient as Flurbiprofen 0.03% in terms of control of post ALT inflammation, with a good tolerance.

Double-Blind Method↗
PubMed1994

Optic atrophy as the presenting sign in Hallervorden-Spatz syndrome.

A girl of eight years of age is described with the Hallervorden-Spatz syndrome. Optic atrophy with progressive visual loss was the only presenting symptom for three years. Behavioural and motor disturbances emerged after that time. Optic atrophy can be the first and for some time only symptom of the Hallervorden-Spatz syndrome.

Brain↗
PubMed1994

Corneal topography.

Computer-assisted videokeratography systems are becoming the prevailing method for analysis of the corneal surface. A realistic insight into the limitations of these topography systems is critical for proper interpretation of the data. Methods based on reflections have limited accuracy when measuring aspherical surfaces. The error may become quite extensive when abrupt changes of curvature exist, eg, at the edge of a photorefractive keratectomy. In this case, raster stereographic methods have a theoretical advantage because they determine a true corneal topography, but additional means to visualize the corneal surface must be used and enough sensitivity is more difficult to achieve. Improved calculations have provided a better approximation of the ideal contour a cornea should have to provide optimal visual performance. New methods are proposed to evaluate the optical aberration induced by a given cornea and to discern focusing errors that are correctable with eyeglasses from irregular astigmatism that is not.

Cornea↗
PubMed1994

[Congenital malformations of the eyeball and its appendices in Zaire].

OBJECTIVE: to determine the epidemiology of congenital eye malformations. METHODS: the records of 1740 patients (1913 eyes) with congenital eye malformations seen from 1962 through 1992 were reviewed. RESULTS: the prevalence rate of congenital eye malformations was 2.2%. Congenital cataract (38%), atresia of the naso-lacrimal duct (10%), congenital glaucoma (9%), congenital ptosis (8%), microphthalmos (8%), albinism of iris (8%), microcornea (7%) were the most frequent eye malformations. The common types of associated malformations included albinism, microcephaly, cardiopathy and anomalies of ears. CONCLUSION: the findings of this study were similar to those published in Europe and United States.

Abnormalities, Multiple↗
PubMed1994

Method for detection of conjunctival chlamydial infection and allergic conjunctivitis.

In this study 104 adult patients with chronic conjunctival irritation without obvious diagnosis were investigated by conjunctival scrapings. The smears were stained with May-Grünwald-Giemsa or fluorescein-conjugated monoclonal antibodies prepared against Chlamydiae. In 45 cases it was possible to make a correct diagnosis of Chlamydia infection (29%) or allergy (20%).

Adult↗
PubMed1994

Ocular findings in prematurely born children at the age of 12.

A group of 79 prematurely born children was assessed ophthalmologically at the age of 12 and compared with a group of 100 12 years old children born at term. Of the 79 children, results of neonatal eye examinations were available in 26 prematures (52 eyes). In 28 eyes no signs of retinopathy of prematurity (ROP) were detected (non-ROP group). In 24 eyes a stage 1 or 2 retinopathy of prematurity was present (ROB group). 75% of the children with ROP had an ophthalmological problem. Myopia (29%), hypermetropia (21%), astigmatism (37%) and strabismus (33%) were significantly higher. Considering the whole group of prematurely born children, there was more astigmatism (11%) and strabismus (13%). Preterm children, with or without ROP, are more prone to develop ocular problems.

Adolescent↗
PubMed1994

[The Farnsworth-Munsell 100 Hue test in the Bantu population. Preliminary results].

The purpose of this work was to establish in this first report the age standards of the Farnsworth-Munsell 100 hue in Zaire. The Farnsworth-Munsell 100 Hue test was performed in 132 normal subjects. All subjects were Zairian blacks aged from 20 to 49 years. The test was administered binocularly, once, to each subject. Subjects were divided in three age groups. The first age group had 35 subjects aged between 20 and 29 years, the second age group had 48 subjects aged between 30 and 39 years and the third 49 subjects aged between 40-49 years. The total error scores were 7.06 +/- 2.10 for the first age group, 9.03 +/- 1.80 for the second age group and 9.80 +/- 2 for the third age group. These results were aged related (r = 0.42, p inferior to 0.05). Scores of Zairian subjects in this study were higher when compared to those reported in Europe and U.S.A. Interpretation of results of the Farnsworth-Munsell 100 hue test must take in account this difference in ethnic origin.

Adult↗
PubMed1994

Silastic intubation for Canaliculus communis stenosis.

Silastic intubation was performed for Canaliculus communis obstruction in 32 cases. Two eyes showed additional impatent nasolacrimal duct and were not treated. The silastic intubation was performed by aid of a long, hollow blunt injection needle which allows us to check the patency of the lacrimal system once the stenosis of common canaliculus is perforated. The success rate for isolated silastic intubation was 70%, which is similar to the results of other often more invasive surgical techniques for Canaliculus communis stenosis.

Adult↗
PubMed1993

A subgroup of bipolar cells in human retina is GABA-immunoreactive.

The distribution of GABA in the perifoveal and the near and far peripheral region of human retina was studied with peroxidase anti-peroxidase immunocytochemistry applied on semithin epoxy resin sections. Among the labeled amacrine cells in these regions, four types can be identified: putative diffuse A2 amacrines, stratified semilunar amacrines, interstitial amacrines and small displaced amacrines. GABA-immunoreactive interplexiform cells and ganglion cells also occur. Contrary to previous post-embedding studies, our preparations show that some bipolar cells in the near and far peripheral region are GABA-immunopositive. This indicates that a number of bipolar cells in human retina does have an enhanced GABA content.

Eye Enucleation↗
PubMed1993

New aspects of dopaminergic interplexiform cell organization in the goldfish retina.

Dopaminergic interplexiform cells (DA-IPCs) in the goldfish retina have been reexamined by light and electron microscopic immunocytochemistry with antisera against dopamine (DA) or tyrosine hydroxylase (TH). Successful immunostaining with a specific anti-DA antiserum offers further direct support for DA-IPCs. Anti-DA immunocytochemistry in combination with [3H]-DA autoradiography shows 92% colocalization of the two markers, indicating that [3H]-DA autoradiography is a reliable technique for identification of DA-IPCs. Incubations with anti-TH antiserum show that immunoreactive DA-IPCs have a homogeneous distribution, with an average frequency of 71 +/- 8 cells/mm2 in retinas of 14-15 cm long goldfish. Their arrangement is distinctly nonrandom. Electron microscopy of TH-immunoreactive cell processes confirms that horizontal cell axons synapse onto DA-IPCs and adds the following junctional arrangements to the circuit diagram of the DA-IPC: 1) adjacent serial synapses between DA-IPCs, external horizontal cells, and putative glycinergic interplexiform cells, 2) junctional appositions between DA-IPCs and photoreceptor cells, 3) junctional appositions between neighbouring DA-IPCs, and 4) the "gap junctional complex," typically consisting of a DA-IPC process juxtaposed with a gap junction between horizontal cell axons. The gap junction is flanked by clusters of small, round vesicles and groups of electron-dense structures resembling intermediate filaments. These morphological results support the functional involvement of DA-IPCs in adaptive retinomotor movements and in horizontal cell gap junction modulation and/or dynamics. They also suggest particular interaction between the dopaminergic and the glycinergic IPC system in the outer plexiform layer of goldfish retina.

Animals↗
PubMed1993

Antioxidant activity of plasma from subjects with and without senile cataract.

The relationship between overall plasma antioxidant activity and senile cataract was examined in 148 subjects aged 37-90 years. Antioxidant activity of plasma from 52 control and 96 patients with senile cataract was determined by a method which measures the capacity of plasma to inhibit auto-oxidation of bovine brain homogenate. In contrast to previous studies which demonstrated a relationship between decreased levels of antioxidant components in blood and the occurrence of lens opacities, the present study does not show any significant difference between subjects with and without senile cataract.

Adult↗
PubMed1993

A new epithelial cell type in the human cornea.

PURPOSE: To study the expression of intermediate filaments in the human cornea. METHODS: Light and electron microscopic and immunohistochemical studies were performed on 20 corneas from subjects of various ages. RESULTS: A hitherto unrecognized epithelial cell population emerged from the immunohistochemical studies. Epithelial cells were invariably present in the superior cornea, whereas the nasal, temporal, and inferior segments almost lacked these cells. They were situated at the transition between peripheral cornea and limbus, and occurred as small groups in the basal epithelium. On electron microscopy, they were recognized by their marginated nuclear chromatin, large nucleoli, prominent bundles of intermediate filaments, and numerous hemidesmosomes and desmosomes. Immunohistochemistry on frozen sections revealed a unique intermediate filament make-up: ie, strong co-expression of vimentin and cytokeratin 19; other intermediate filaments, including cytokeratins 3, 4, 6, 7, 8, 10, 13, and 18 were negative. Finally, the cells lacked ultrastructural and immunohistochemical features of melanocytes, neuroendocrine cells, Langerhans' cells, and leukocytes. CONCLUSIONS: A new epithelial cell type in the human cornea is described with characteristic morphologic and immunohistochemical features. According to their particular segmental distribution, restricted localization at the junction between cornea and limbus, and expression of an "early" intermediate filament profile, it is tempting to speculate that they represent stem cells of the human cornea. Further studies are aimed to characterize their phenotype and function more extensively.

Aged↗
PubMed1993

A retinoblastoma with an unusual aspect in a 5-year-old girl.

A five-year-old girl presented with a white, semitransparent, slightly elevated retinal lesion in the left eye, with as most probable diagnosis retinoblastoma. Fluorescein angiography showed intraretinal vascular abnormalities and leakage. On computed tomography and ultrasound no calcifications were identified. As the tumor had grown, enucleation was performed and the diagnosis of retinoblastoma was confirmed by routine histology and by immunohistochemistry.

Child, Preschool↗
PubMed1993

The transitional zone between limbus and peripheral cornea. An immunohistochemical study.

PURPOSE: The authors investigated the phenotypic characteristics of basally located "transitional cells" in peripheral superior cornea, characterized previously by their coexpression of cytokeratin 19 and vimentin and their negativity for AE5. METHODS: Twenty adult human corneas were studied, using in situ immunohistochemical techniques and a panel of specific monoclonal antibodies against various surface and cytoplasmic molecules. RESULTS: The transitional cells shared staining characteristics with limbal basal cells in their expression of alpha 6 beta 4-integrin, metallothionein, AE1, and transferrin receptor. CONCLUSIONS: These "transitional" epithelial cells exhibit a unique phenotype differing from that of the surrounding basal epithelial cells in the peripheral cornea but analogous to that of limbal basal cells. These findings further corroborate the hypothesis that, at least from an immunohistochemical point of view, transitional cells in the superior peripheral cornea exhibit stem cell characteristics.

Aged↗