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L Morphis

Publications and source records attributed to L Morphis.

5 recordsLinked to original sources

Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo.

Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.

Aminophylline

Influence of exchange transfusion on the development of serum immunoglobulins.

Thirteen neonates with severe jaundice of various etiologies were followed after exchange transfusion for a period of one year. Blood levels of IgG, IgA, and IgM were measured before and after exchange transfusion, four and ten days later, and at 1, 3, 6, 9, and 12 months of age. Normal and jaundiced but not exchange-transfused infants, matched for age, were used as control subjects. It was concluded that exchange transfusion suppresses the production of autologous IgG and IgA, whereas it provokes IgM synthesis.

Clinical Trials as Topic