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L N Abramova

Publications and source records attributed to L N Abramova.

At least 19 recordsLinked to original sources
PubMed1992

[A comparative experimental study of pathogenic properties of new strains of California encephalitis virus serogroups].

Experiments in noninbred mice, Syrian hamsters and grey monkeys were made to characterize the pathogenic properties of new strain of the California encephalitis serogroup isolated for the first time on the island of Taimir, in the Murmansk, Leningrad, Tver regions and in Karelia. All the strains displayed marked tropism for the CNS. The strains isolated in the northern regions of this country turned out more pathogenic for the animals. The strain Leiv-12812 Kl (isolated in the Tver region) differed from the remaining ones in more pronounced pathogenicity for the monkeys, as well as in the site and intensity of brain lesions. The persistence of the virus in hamsters organs may play a role of a reservoir of infection in nature.

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PubMed1991

[Experimental infection caused by Issyk-Kul' arbovirus].

Experimentally in green monkeys, Syrian hamsters and white mice the authors studied the pathogenic properties of a new virus Issyk-Kul. The virus was determined in all animals--in blood and organs (brain, lungs, liver, spleen, kidneys). During the histological investigation the inflammatory and dystrophic injuries were established: in CNS, lungs, liver and kidneys. There was a distinct immunomorphological reaction in the spleen. The virus has pantropic properties and causes a generalized infection in animals.

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PubMed1989

Biological profile of a virus belonging to California encephalitis complex isolated in Karelian Autonomous Soviet Socialist Republic.

We investigated in white mice and in Syrian hamsters the pathogenesis of infection with a virus belonging to the California encephalitis complex isolated in the Karelian Autonomous Soviet Socialist Republic. The pathogenic properties of the virus were investigated also in green monkeys. The localization and character of lesions in the organs of given animals appeared to be similar. The virus appeared to possess neurotropic activity, it propagated in the animal body by haematogenous route. The virus was found to be heat-resistant and pH-sensitive.

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PubMedDate not supplied

[An experimental infection caused by the Issyk-Kul arbovirus].

Pathogenic properties of Issyk-Kul virus have been experimentally studied in green monkeys, golden hamsters and white mice. The virus was identified in the blood and organs of all the animals. Pathohistological studies have revealed inflammatory and dystrophic changes in the central nervous system, lungs, liver and kidneys. Pronounced immunomorphological changes have been observed in the spleen. The virus possessed pantropic properties and caused generalized infection in all the animals irrespective of the mode of infection. In monkeys asymptomatic infection was accompanied by marked organ damages and virusemia. The presence of specific antibodies in the blood indicated a low efficacy of humoral immunity in this infection.

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PubMedDate not supplied

[Results of infecting experimental animals and monkeys with Karshi virus].

The paper presents the results of a comparative experimental study of pathoginicity of the Karshi virus (Flaviviridae) isolated from Ornithodoros papillipes ticks collected in Uzbekistan, for white mice, Syrian hamsters and green monkeys using various administration routes. Localization and types of lesions (brain, lungs, liver, spleen, kidneys) as well as the presence of viruses in blood and body organs are described basing on histological and virusological studies. Specific antibodies are found in monkeys' blood sera. Hematogenic route of distribution of the virus and its pantropical character are revealed. White mice are found to be the most sensitive model.

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PubMedDate not supplied

[Antiviral activity of ribamidyl in experimental infections with California encephalitis group viruses].

A preparation of ribamydil, an analogue of natural nucleosides, synthesized at the Latvian SSR Institute of Organic Chemistry showed a sufficiently high activity against bunyaviruses of California encephalitis complex both in vitro and in vivo. Various modifications of the enzyme immunoassay may be used for control of the effectiveness of treatment with this drug. Some advantages of the subcutaneous route over the intramuscular one were found. Ribamydil may be useful for treatment of infections of California encephalitis complex.

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PubMedDate not supplied

[Biological properties of the Tahyna virus isolated in the Arctic].

The results are presented of comparative studies over the course of experimental Tahyna infection of viremia in the blood and organs, localization and patterns of lesions in the same organs after different routes of inoculation of white mice and hamsters with a new strain LEIV 9843 Mur of Tahyna virus. The results of these experiments are compared with similar studies in monkeys with asymptomatic infection, including humoral antibody detection. The pattern of lesions in the organs of animals infected with Tahyna virus (LEIV 9843 Mur strain), the mode of virus spread, tissue tropism of the virus were established. The virus thermostability and sensitivity to different pH values of the medium were determined.

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PubMedDate not supplied

[Comparative characteristics of the pathogenicity of 2 viruses of the family Rhabdoviridae for monkeys].

Pathogenic properties of two viruses, Sowgrass and Barur, of the Rhabdoviridae family, isolated in different geographical zones were studied comparatively in green monkeys. These viruses showed different pathogenicity for monkeys by the intracerebral and subcutaneous routes of inoculation. Sowgrass virus had no manifest pathogenicity for monkeys, whereas Barur virus caused death of the animals in 5-6 days after intracerebral inoculation with typical localization of lesions in the brain. Subcutaneous inoculation of the animals produced no fatalities; slight lesions in organs and production of virus-neutralizing antibodies in the blood were observed.

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PubMedDate not supplied

[Use of an immunoenzyme method for research on antichlamydial sera].

Data on comparative studies of the sensitivity of enzyme-linked immunosorbent assay (ELISA), complement fixation test (CFT), and indirect immunofluorescence test (IIFT) in titration of antibodies to chlamydial agents of calf enteritis and pneumonia in sera of immunized rabbits are presented. The data indicate that ELISA is 10-40 times more sensitive than CFT and IIFT and may be used for large-scale diagnostic studies in chlamydial infections of cattle.

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PubMedDate not supplied

[Causative agent of benign lymphoreticulosis].

A causative agent ("D" strain) was isolated from the contents of an affected lymph node of a patient with beningn lymphoreticulosis. According to the biological and antigenic properties this agent is identified with Chlamydia but is a distinct species. The chlamydial etiology of benign lymphoreticulosis is determined also by the complement-fixation test with sera from convalescents.

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