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Biomedical subjects

L N Ajabor

Publications and source records attributed to L N Ajabor.

At least 19 recordsLinked to original sources

Breast cancer in pregnancy and lactation.

Thirty-six Nigerian women admitted with breast cancer during pregnancy and/or lactation (SGP) are the basis of this study of breast cancer in pregnancy and lactation. Thirty-six non pregnant but age and c TNM stage matched breast cancer patients and another thirty-six non pregnant, age matched women with benign breast neoplasms served as control group A (CGA) and control group B (CGB) respectively. Even though of similar c TNM state, the mean duration of tumor presence in the SGP (6 months) was shorter than in CGA (12 months). Also the SGP presented with tumor of higher histological grade (grade III, 55.6%) than those of CGA (grade III, 19.4%). These lead to the conclusion that breast cancer in the study group patients was more rapidly progressing and was therefore of worse prognosis. This conclusion is confirmed by a finding of survival in CGA patients that was 1.4 times that of the study group patients. We therefore conclude that breast cancer associated with pregnancy or lactation in Nigerian women progresses more rapidly and has a worse prognosis than cancer in their non pregnant counterparts.

Adult↗

The problems of management of gestational trophoblastic neoplasms at the University of Benin Teaching Hospital, Benin City, Nigeria.

Analysis of 31 cases of gestational trophoblastic neoplasms at the University of Benin Teaching Hospital, Benin City, over a 7 1/2 year period (1/1/75 to 6/30/82) was carried out. The incidence of this disease was 1:656 deliveries. Although it was more prevalent in grandmultipara, it occurred in all parities and ages. The main clinical features were secondary amenorrhea, vaginal bleeding, uterine enlargement, and vaginal secondaries. The most common gestational antecedent event of gestational trophoblastic disease was a normal pregnancy. This was believed to have contributed to the high overall mortality of 35.5%. Numerous shortcomings during the management of these cases (inadequate laboratory facilities, shortage of reagents, shortage of drugs) were highlighted.

Adult↗

Radiology of obstetric vesicovaginal fistula.

The excretory urograms of 70 Nigerian women presenting to the University of Benin Teaching Hospital with obstetric vesicovaginal fistula over a 7-year period are analyzed. The common abnormalities are medial deviation of distal ends of ureters (34%); discrete but smooth pseudoprostatic bladder base indentation (33%); and calyceal clubbing of varying degrees (19%). Other abnormalities observed include hydroureters (18%); bladder calculi (7%); bladder wall calcification (3%), and unilateral nonfunctioning kidneys (3%).

Adolescent↗

Response of unmarried adolescents to contraceptive advice and service in Nigeria.

The responses of a group of all unmarried, sexually active teenagers in a developing country to offers of contraceptive service were assessed in a prospective, 30-month study at a teaching hospital family planning center. Teenagers of this group constituted 7.2% of the clinic population. The default rate was very high (43.0%) and was most noticeable among users of oral contraceptives. The intrauterine device seemed more acceptable, as were injections of norethisterone enanthate. Possible reasons for this pattern of response are given, and the authors suggest giving new consideration to making the intrauterine device more suitable for and acceptable to teenagers of developing countries. The place of norethisterone enanthate in teenage contraception is also discussed.

Adolescent↗

Evaluating retrograde hysterectomy in the surgery of pelvic gynaecologic diseases in Nigeria.

A modified technique of total abdominal hysterectomy in the presence of gross distortion of pelvic anatomy with displacement of vital structures by chronic pelvic inflammatory disease with or without tubo-ovarian abscess formation and adherent giant myomas of the uterus is described. In the 16 cases personally operated upon by the author there were no major operative or post-operative complications. Experience with this procedure is reviewed and its wider use advocated. The removal of the uterus and adnexa by the abdominal route is one of the commonest procedures in gynaecological practice. The technique is fairly well standardized and is a relatively simple operation provided that the surgeon has a thorough knowledge of the anatomy of the pelvic organs. In our practice at Ibadan, it is fair to say that the uterus of normal size and mobility to which most textbook descriptions of technique apply forms a minority of the cases presenting for total abdominal hysterectomy. Experience has shown that there is a high incidence of chronic pelvic inflammatory disease with or without tubo-ovarian abscess formation, adherent giant myomas of the uterus, cervical and intra-ligamentous fibroids and cysts and enlarged adherent benign ovarian tumours in the community. These may cause distortion of pelvic anatomy with displacement of the ureters, bladder, colon and rectum from their normal position. Experience has shown that urinary tract and colonic injuries may occur at operation when the pelvic anatomy is grossly distorted making true anatomical dissection often impracticable. Operative treatment can be very difficult in these instances and success depends on correct surgical technique with suitable instruments and personal experience, the necessary versatality and skill developed with practice. Various techniques for abdominal hysterectomy have been developed and reported (Richardson, 1929; Farrar, 1935; Aldrige, and Meredith 1950; Gray, 1958; Murless, 1963; Cabaniss, and Gill, 1964). The technique to be described was originally developed by Bonny (Macleod and Howkins 1964) except for minor modifications and has been used exclusively by the author in the last three years in selected cases with gross pelvic anatomic distortion where the conventional method of abdominal hysterectomy is impracticable. This improved surgical technique has decreased the hazards of pelvic surgery tremendously in difficult hysterectomies in my practice.

Adult↗

Primary carcinoma of the fallopian tube in a Nigerian.

The first documented report of a rare neoplasm, primary carcinoma of the fallopian tube in a postmenopausal Nigerian is presented. The patient complained of postmenopausal bleeding which persisted after curettage and satisfactory treatment of a pre-existing senile vaginitis and cervicitis. The diagnosis of tubal carcinoma was made only at the time of exploratory laparotomy at which a total hysterectomy and bilateral salpingo-oophorectomy was performed and confirmed at histopathological examination of the specimen. Problems relating to its unusual symptomatology, its association with pelvic inflammatory disease and pelvic tuberculosis, diagnostic difficulties, choice of treatment and factors that may influence survival are discussed.

Adenocarcinoma↗