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Biomedical subjects

L N Benusiglio

Publications and source records attributed to L N Benusiglio.

7 recordsLinked to original sources
PubMed1980

[Changes in the hemodynamics of the lung and the right ventricle during rest and exertion in 2 groups of patients with chronic broncho-obstructive syndrome of different severity].

Forty patients with chronic obstructive pulmonary disease (COPD) underwent right heart and central catheterization at rest and during exercise when not in a state of acute exacerbation. They were divided into 2 groups of different functional gravity: group I: FEV1 less than or equal to 1250 ml, RV/TLC greater than or equal to 55% (24 patients); group II: FEV1 > 1250 ml, RV/TLC < 55% (16 patients). At rest, group I had mean pulmonary artery pressure, pulmonary arteriolar resistance, and arterial PCO2 significantly higher, and arterial PO2 significantly lower, than group II. There was no difference in cardiac index, mean atrial pressure and pulmonary wedge pressure between the two groups. During exercise, mean right atrial and pulmonary wedge pressure increased markedly in group I and showed a significant difference from the values of group II. For pooled data of groups I and II, there was a correlation between FEV1 and mean right atrial pressure under exercise and between arterial PO2 and right atrial pressure under exercise. It is concluded that (1) subdividing patients with COPD, as reported here, determines two different blood gases and pulmonary hemodynamic subsets when taken at rest; (2) during exercise, group I patients have "abnormal" right and left ventricular function; (3) FEV1 and arterial PO2 on physical exertion serves to predict mean right atrial pressure under exercise.

Blood Pressure↗
PubMed1980

Time course of lung function changes in atypical pneumonia.

We measured pulmonary function in each of 21 patients suffering from "atypical", non-bacterial pneumonia during the acute illness and during convalescence (two to 18 months) to study the course and the nature of functional impairment at different stages of the disease. In six patients, no aetiological agent was found. An aetiological agent was identified in 15 of the patients: Mycoplasma pneumoniae (seven patients), influenza A (three patients), parainfluenza 3 (one patient), varicella (two patients), Q fever (one patient), coxsackie B3 (one patient). At the time of admission we observed a restrictive pattern in 52%, an obstructive pattern (decreased FEV1/FVC ratio) in 52% abnormalities in distribution of ventilation (abnormal slope of phase 3) in 63%, and abnormalities in gas exchange (increased AaDO2) in 75% of the patients. The frequency of abnormalities in these pulmonary function tests decreased dramatically after two to four weeks and nearly disappeared in most patients during convalescence. The only major residual abnormality was a decreased FEV1/FVC ratio in five subjects, four of whom were smokers. However, when MMEF and V75 were measured at this stage, their average value for all the groups of patients with the exclusion of the Mycoplasma pneumoniae group, was markedly reduced. These data suggest that small airways involvement can be demonstrated during the convalescence of patients recovering from various types of atypical pneumonia other than those caused by Mycoplasma pneumoniae.

Adult↗
PubMed1979

[Correlations between hemodynamic measures and respiratory functions in patients with chronic obstructive lung syndromes].

Fourteen patients with chronic obstructive pulmonary disease underwent right catheterization with a Swan-Ganz catheter to correlate lung function with hemodynamic features at rest and on exercise. There appears to be a good correlation between some pulmonary function tests (FEV1, RV/TLC, PaO2 at rest and on exercise) and mean pulmonary artery pressure at rest and on exercise in these patients.

Blood Pressure↗
PubMed1977

Glomerulonephritis associated with hepatitis B. report of a case and review of the literature.

A 45-year old developed membranoproliferative GN seven years after acute hepatitis. He was found to be a chronic carrier of HBsAg, and glomeruli contained granular deposits of immunoglobulins (Ig), complement (C) and HBsAg. Six months later, HN persisted, but HBsAg has disappeared from glomeruli; Ig and C were still present. It was concluded that GN was probably due to a hepatitis B associated antigen, but not necessarily to HBsAg.

Acute Disease↗