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Biomedical subjects

L N Danilov

Publications and source records attributed to L N Danilov.

At least 19 recordsLinked to original sources
PubMed1991

[The structural changes in the lungs and the phospholipids of the pulmonary surfactant in experimental bleomycin-induced pneumosclerosis in rats].

Light microscopy was used to study rat lungs. Some morphological and biochemical characteristics after single bleomycin intratracheal administration in a dose of 10 mg/kg were studied. Some metabolic changes in the alveolar epithelium and vascular endothelium were estimated quantitatively. The peculiar picture of acute toxic alveolitis in the early stage of the injury and the features of fibrotic alveolitis by the 30-60th day were observed. The LDH and succinate dehydrogenase activities in the alveolar epithelium increased by the 3-7th day and returned to normal by the 30th day. At the same time the PL content increased 2-fold by the 30-60th day. The lysolecithin, sphingomyelin and phosphatidylserine concentration increased on the 3-7th day and returned to normal level on the 14th day. The phosphatidylglicerol content decreased significantly by the 60th day.

Animals↗
PubMed1990

[Changes in the functional state of the adrenal glands in experimental bronchospasm in dogs].

Changes in the adrenal functional state were revealed during the development of bronchoconstriction induced by allergen inhalation in 7 dogs sensitized with ovalbumin. The decrease in V1 (expiratory flow-volume) on an average by 58% was noted after inhalation of 1000 microG of ovalbumin. The significant decrease in II-hydroxycorticosteroids (II-OCS), adrenaline, noradrenaline, dopamine, and a tendency to the increase in histamine content were observed in the venous blood plasma. The decrease in the adrenaline content in plasma apparently contribute to the development of early bronchoconstrictor response, and the decrease in II-OCS maintain the development and the progress of late bronchoconstrictor response.

Adrenal Glands↗
PubMed1989

[Role of the rise of pressure in the pulmonary artery in the distribution of perfusion and gas exchange in bronchial obstruction].

The experiments on the dogs revealed that the damage of lobar bronchus conduction resulted in the decrease of O2 tension in pulmonary venous blood of this lobe. The decrease in the ventilation and blood flow was found in the zone of obstruction by using tracers 133Xe and 99mTc. The pressure rise in the pulmonary artery caused by the spread of bronchial obstruction is one of the factors promoting the redistribution of perfusion into the reserve zones of lungs. The decrease of pressure by the ganglio-blocking preparation results in the increase of arterial hypoxemia.

Animals↗
PubMed1985

[Changes in systemic and pulmonary hemodynamics during an increase in lung volume].

15 anesthetized dogs were subjected to a gradual increase of the lungs volume by means of administration of the 50% gas mixture of oxygen and air. The exceeding of the lungs volume by 600 ml increased pressure in the caudal vein, reduced blood flow and systolic pressure in the heart ventricles. After administration of 800 ml of the gas, the systolic pressure started to raise in the right ventricle and achieved 36.8 mm Hg at the moment of intrathoracic pressure of 21.5 mm H2O and cessation of the minor circulation. Then the right ventricle augmented its mechanic activity inducing tachycardia, raise of the pressure up to 45.2 mm Hg and restoration of the lung circulation.

Animals↗
PubMed1979

[Acne in infants].

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Acne Vulgaris↗