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Biomedical subjects

L N Guo

Publications and source records attributed to L N Guo.

8 recordsLinked to original sources
PubMed1994

[Serous adenocarcinoma of the endometrium].

From 1982 to 1992, 9 cases of clinical stage I serous adenocarcinoma of the endometrium were diagnosed and treated surgically in PUMC Hospital. Of these 9 patients, myometrial invasion occurred in 8 patients, lymphatic invasion in the myometrium was demonstrated in 7 patients and 6 patients were found to have extrauterine spread. The tumors studied in this paper confirmed the aggressive behavior of this particular histologic type of endometrial carcinoma. The pathological characteristics and differential diagnosis are presented.

Aged↗
PubMed1993

[Atypical hyperplasia and complex hyperplasia of endometrium in women of reproductive age].

The initial and follow-up endometrial curettings from 17 patients with atypical hyperplasia (AH) and 4 patients with complex hyperplasia (CH) were reviewed. All cases were younger than 40 years and the duration of follow-up ranged from 7 months to 38 years (mean, 11.3 years). According to the ISGP classification, the histological diagnostic criteria based solely on the presence of cytologic atypia. Twenty of them received progestin treatment and the lesion regressed at some time, but relapsed eventually. Twelve of them were performed hysterectomy after repeat progestin administrations and only 2 (11.8%) of 17 patients with AH progressed to invasive carcinoma 6 to 8 years later; however, all 4 patients with CH and 2 patients with milder forms of AH became pregnant and had normal term deliveries during the follow-up period. The histological diagnosis, prognoses and the effects on fertility in patients with AH and CH are discussed.

Adult↗
PubMed1992

The role of flow cytometry and morphometry in discriminating benign from malignant nonfunctioning pancreatic endocrine tumors.

Nonfunctioning pancreatic endocrine tumor (NFPET) is a kind of tumor with high malignancy but bland in morphological features. It is impossible to predict the malignancy solely by gross and light microscopic pictures of the tumor. For the purpose of assessing the value of flow cytometry and morphometry in predicting the prognosis of NFPET, the DNA content and several morphological parameters of 26 NFPETs were determined by appropriate techniques. The results show that abnormal DNA content has no practical value in discriminating benign from malignant NFPETs; whereas the "score" obtained by combining the morphological measurements of the number of nuclei/mm2 and N/C, is of certain referential significance in predicting the malignancy of NFPET.

Adenoma, Islet Cell↗
PubMed1990

[Malignant Brenner tumor and transitional cell carcinoma of the ovary].

The clinical and pathologic features of 2 malignant Brenner tumors (MBT) were compared with those of 13 primary ovarian transitional cell carcinomas (TCC). Though histologically both tumors were invasive transitional cell carcinoma, TCC differed from MBT by the absence of benign Brenner component and stronger aggressiveness in behavior. Among tumors of both types in similar clinical stage, most of TCC (6/9) died within 1 to 2 years after the operation, but one of MBT died 4 years postoperatively. The distinction between MBT and TCC bearing on therapeutic as well as prognostic implications is discussed.

Adult↗
PubMed1989

[The effect of electro-acupuncture of "neiguan" acupoint on cortical potential evoked by stimulating C-fibers of splanchnic nerve].

In this paper the averaged cortical evoked potential (C-CEP) induced by stimulating the C-fibers of the splanchnic nerve was used as an index of visceral pain to further study the effects of acupuncture and morphine on it. Experiments were carried out on 35 cats anesthetized with chloralose and immobilized with flaxedil. The splanchnic nerve was stimulated with electric pulses of varied strength and blocked by a galvanic current so as to cause A- or C-fibers input selectively. The cortical evoked potential was recorded on the contralateral post-sigmoid gyrus and averaged by TQ-19 Medical Data Processor. The compound action potential of splanchnic nerve was monitored. "Neiguan" acupoint was stimulated with electric pulses (0.1ms, 4v and 5Hz). The results were as follows: 1) when "Neiguan" acupoint, was excited with the electric pulses, C-CEP and the late component of A-CEP which was evoked by stimulating A-fibers of splanchnic nerve were obviously reduced in amplitudes. It was suggested that electro-acupuncture (EA) of "Neiguan" acupoint could inhibit visceral pain (the slow and fast pain). 2. After intravenous injection of morphine, the amplitudes of C-CEP and the late component of A-CEP were depressed significantly, indicating that C-CEP might reflect the visceral slow pain and the late component of A-CEP reflect the fast pain. 3. Naloxone could block partially the inhibitory effect of EA of "Neiguan" acupoint on C-CEP, suggesting that the inhibition of EA might be associated with the release of endogenous opiate like substances.

Acupuncture Points↗